Legacy ID: 18-003-43000
Size: 0.1 mg
Source: Rabbit
Reactivity: Human
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Details for AREB6

Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of human AREB6. ELISA Titre: 1:62500 Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Transcription Factor AREB6 / transcription factor 8 /zinc finger homeodomain enhancer-binding protein inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter act

Function: Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type.

Subcellular Location: Nucleus.

Tissue Specificity: Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.

Disease: Defects in ZEB1 are the cause of posterior polymorphous corneal dystrophy type 3 (PPCD3) [MIM:609141]. Posterior polymorphous corneal dystrophy (PPCD) is a rare disease involving metaplasia and overgrowth of corneal endothelial cells. In patients with PPCD, these cells manifest in an epithelial morphology and gene expression pattern, produce an aberrant basement membrane, and, sometimes, spread over the iris and nearby structures in a way that increases the risk for glaucoma.

Similarity: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

Similarity: Contains 7 C2H2-type zinc fingers.

Similarity: Contains 1 homeobox DNA-binding domain.

Summary: TCF8 encodes a zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene (MIM 147680) expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site (Williams et al., 1991 [PubMed 1840704]).[supplied by OMIM]. Williams. T.M. et al.. (1991) Science 254 (5039). 1791-1794.

Additional Info for AREB6

Name AREB6
Related Product Names Transcription factor 8; NIL-2-A zinc finger protein; Negative regulator of IL2 AREB6, BZP, NIL-2-A, NIL-2A, ZEB, ZEB1, ZFHEP, ZFHX1AAREB6AREB6
NCBI Acc Number NP_110378.2
GI Number 28077091
Purity Rabbit Ig G is purified by Protein G/A affinity chromatography method.
Format Suggested dilution at 1 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody.
Stability Note: Avoid repeat freeze-thaw cycles.
Clonality Polyclonal
Storage Antibody is lyophilized from PBS buffer with 2% sucrose. Add 100 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C.
Molecular Weight 124074
Sequence Length 1124
Swiss Prot Number P37275

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