BMP-2 Human

GenWay ID: GWB-2B6A68
Legacy ID: 10-663-45126
Source: E. Coli
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Details for BMP-2 Human

Amino Acid Sequence MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC CPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR.
Biological Activity The ED50 as determined by its ability to induce alkaline phosphatase production by ATDC-5 cells is 0.5-1.0 μg/ml.
Protein Content Protein quantitation was carried out by two independent methods
  1. UV spectroscopy at 280 nm using the absorbency value of 1.4 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
  2. Analysis by RP-HPLC, using a standard solution of BMP-2 as a Reference Standard.
Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility It is recommended to reconstitute the lyophilized Bone Morphogenetic Protein-2 in sterile 100mM AcOH (acetic Acid) not less than 100ug/ml, which can then be further diluted to other aqueous solutions. Bone Morphogenetic Protein-2 Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated, Polypeptide chain containing 115 amino acids and having a molecular mass of 26018 Dalton.
The BMP-2 is purified by proprietary chromatographic techniques. BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.
Function Induces cartilage and bone formation.
Subunit Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1.
Subcellular Location Secreted
Tissue Specificity Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Similarity Belongs to the TGF-beta family.

Additional Info for BMP-2 Human

Name BMP-2 Human
Related Product Names BMP-2, BMP2A.; BMP-2; BMP-2A BMP2ABMP-2 HumanBMP2
NCBI Acc Number NP_001191.1
Purity Greater than 95.0% as determined by:(a) Analysis by RP-HPLC
(b) Analysis by SDS-PAGE.
Format BMP-2 was lyophilized from a concentrated (1mg/ml) sterile solution containing 10mM sodium citrate pH=3.5.
Stability Lyophilized Bone Morphogenetic Protein-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 C. Upon reconstitution BMP2 should be stored at 4 C between 2-7 days and for future use below -18 C.
For long term storage,
Molecular Weight 0.5
Swiss Prot Number P12643

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