NUCLEAR ANTIGEN, Antibody

GenWay ID: GWB-419A69
Legacy ID: 20-783-73547
Size: 0.1 ml
Source: Mouse
Reactivity: Reacts with: Rat N.B.Antibody reactivity and working conditions may vary betwen species.
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Details for NUCLEAR ANTIGEN, Antibody

Specificity: NUCLEAR ANTIGEN

Isotype: IgG2a

Clone: 21NC85 Immunogen: Native

Specificity Note: This product is histone specific, it stains nuclei and chromosomes of cells from all species including animals and plants. It reacts preferentially with histone H1 by ELISA and immunoblotting. Stains nuclei of all human cell types and also stains chromosomes diffusely in metaphase cells. Intense diffuse staining is obtained in interphase cells.

Target Species: Human

Histology: Human Tonsil

Preparation: Ig fraction prepared by ammonium sulphate precipitation

Buffer Solution: Phosphate buffered saline

Preservative Stabilisers: None present

Suggested Dilution: Suggested Dilution: Immunofluorescence - 1/20 - 1/30 Function: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\'s processibility during elongation of the leading strand.

Subunit: Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1, POLD3 and POLD4.

Subcellular Location: Nucleus.

Ptm: Upon methyl methanesulfonate-induced DNA damage, mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through \'Lys-63\' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH, whih is required for DNA repair.

Disease: Antibodies are present in sera from patients with systemic lupus erythematosus.

Similarity: Belongs to the PCNA family.

Additional Info for NUCLEAR ANTIGEN, Antibody

Name NUCLEAR ANTIGEN, Antibody
Related Product Names MOUSE ANTI HUMAN NUCLEAR ANTIGEN NUCLEAR ANTIGENPCNA
NCBI Acc Number NP_002583.1
Purity Purified IgG prepared by affinity chromatography
Format IgG Fraction - liquid
Stability 18 months from date of despatch.
Clonality Monoclonal
Storage Store at -20°C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Molecular Weight 28769
Applications IHC-F, ELISA, IF, IHC-P, WB

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