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| P2Y purinoceptor 6 Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-461-10114 |
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| Related Product Names:
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P2RY6 antibody; P2RY6; P2Y6; MGC15335; P2Y purinoceptor 6
- P2Y6; Pyrimidinergic receptor P2Y6 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: P2RY6 |
Gene Name Synonym: P2Y6; MGC15335 |
Gi #:
4758864 |
NCBI Acc #:
NP_004145.1 |
Swiss Prot Acc #:
Q15077 |
Length (aa): 328 |
Mol. Weight (Da): 36429 |
Chrom Location: 11q13.5 |
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 Immunogen: C-terminal domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (3 - 16 ug/ml), ICC (Optimal dilution to be determined by the researcher)
Target Protein: Purinergic Receptor P2Y6
Family: GPCR
Subfamily: Purinergic
Summary of Expression: P2Y6 expression has been documented in various blood cells, bone marrow, brain, colon, heart, kidney, ovary, placenta, spleen,and thymus. ESTs have been isolated from cervix, embryo, eye, kidney, liver/spleen, placenta, and vessel libraries.
Source/Host: Rabbit
Purity/Purification: Immunoaffinity Purified
Clonality: Polyclonal
Crossreactivity: Human
Format: Phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
Storage: -4 degree C for short term (weeks) and -70 degree C for long term.
Stability: 6-12 months at -20 degree C.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for P2RY6 ANTIBODY: |
| ICC, IHC: Tested |
| ELISA, Western Blot: Not Tested |
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| TESTING: (secondary reagents and protocols
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IHC: Spleen, Red Pulp ( anti-P2RY6 )P2RY6 antibody IHC image
 ICC: Transfection - cells expressing target protein ( anti-P2RY6 )P2RY6 antibody ICC image
 ICC: Transfection - cells expressing vector only ( anti-P2RY6 )P2RY6 antibody ICC image
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| P2RY6 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for P2RY6 antibody: P2RY6; P2Y6; MGC15335; P2Y6; Pyrimidinergic receptor P2Y6
Function: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Subcellular Location: Membrane; multi-pass membrane protein.
Similarity: Belongs to the G-protein coupled receptor 1 family [view classification].
Summary: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.
P2Y purinoceptor 6 reacts with human.
OMIM: 602451; gene. [NCBI / EBI]
Pathways:
KEGG pathway: Neuroactive ligand-receptor interaction 04080
Products similar to P2RY6 antibody:
IgG
 P2Y purinoceptor 6, IgG
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for P2RY6 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
[1] Wihlborg,A.K., Balogh,J., Wang,L., Borna,C., Dou,Y., Joshi,B.V., Lazarowski,E., Jacobson,K.A., Arner,A. and Erlinge,D.
Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction
[2] Khine,A.A., Del Sorbo,L., Vaschetto,R., Voglis,S., Tullis,E., Slutsky,A.S., Downey,G.P. and Zhang,H.
Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway
[3] Cox,M.A., Gomes,B., Palmer,K., Du,K., Wiekowski,M., Wilburn,B., Petro,M., Chou,C.C., Desquitado,C., Schwarz,M., Lunn,C.,, et al.
The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP
[4] Schafer,R., Sedehizade,F., Welte,T. and Reiser,G., et al.
ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells
[5] Lee,H., Choi,B.H., Suh,B.C., Lee,S.K. and Kim,K.T., et al.
Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells
[6] , Communi D., Parmentier M., Boeynaems J.M.
Cloning, functional expression and tissue distribution of the human P2Y6 receptor.
[7] , Somers G.R., Hammet F., Woollatt E., Richards R.I., Southey M.C., Venter D.J.
Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family.
[8] , Maier R., Glatz A., Mosbacher J., Bilbe G.
Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.
[9] , Maier R., Glatz A., Mosbacher J., Bilbe G.
Biochem. Biophys. Res. Commun. 240:298-302(1997).
[10] , Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., et al.
Large-scale cDNA transfection screening for genes related to cancer development and progression. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: P2RY6 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of P2RY6 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about P2RY6 antibody, all related information, articles, resources about P2RY6 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. This product has been manufactured by MBL International. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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