BDKRB1 antibody, B1 bradykinin receptor Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

B1 bradykinin receptor Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-461-10180

Buy BDKRB1 antibody -

Volume:

Related Product Names:

- BDKRB1 antibody; BDKRB1; BRADYB1; B1R; BKR1; B1BKR; BKB1R; B1 bradykinin receptor
- BK-1 receptor; B1R; Bradykinin receptor B1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: BDKRB1	Gene Name Synonym: BRADYB1; B1R; BKR1; B1BKR; BKB1R
Gi #: 20544172	NCBI Acc #: NP_000701.2	Swiss Prot Acc #: P46663
Length (aa): 353	Mol. Weight (Da): 40495	Chrom Location: 14q32.1-q32.2

Immunogen: 4th cytoplasmic C terminus domain of human. Synthetic peptide - KLH conjugated.

Epitode: Peptide immunogen affinity column

Uses: IHC (24 - 48 ug/ml) (Optimal dilution to be determined by the researcher)

Source/Host: Rabbit

Purity/Purification: Immunoaffinity Purified

Clonality: Polyclonal

Crossreactivity: Human

Format: Phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

Storage: +4 degree C for short term (weeks) and -70 degree C for long term.

Stability: 6-12 months at -20 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for BDKRB1 ANTIBODY:

IHC: Tested

ELISA, ICC, Western Blot: Not Tested

TESTING: (secondary reagents and protocols )

IHC: Nasal mucosa ( anti-BDKRB1 )

BDKRB1 antibody IHC image
BDKRB1

BDKRB1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for BDKRB1 antibody: BDKRB1; BRADYB1; B1R; BKR1; B1BKR; BKB1R; BK-1 receptor; B1R; Bradykinin receptor B1

Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Subcellular Location: Membrane; multi-pass membrane protein.

Similarity: Belongs to the G-protein coupled receptor 1 family [view classification].

Summary: Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.

B1 bradykinin receptor reacts with human.

OMIM: 600337; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Calcium signaling pathway 04020
KEGG pathway: Complement and coagulation cascades 04610
KEGG pathway: Neuroactive ligand-receptor interaction 04080
KEGG pathway: Regulation of actin cytoskeleton 04810

Products similar to BDKRB1 antibody:

IgG

B1 bradykinin receptor, IgG

Bradykinin receptor B1, IgG

ADRB1, IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for BDKRB1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Stadnicki,A., Pastucha,E., Nowaczyk,G., Mazurek,U., Plewka,D., Machnik,G., Wilczok,T. and Colman,R.W.
     Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease
[2] Angers,M., Drouin,R., Bachvarova,M., Paradis,I., Bissell,B., Hiromura,M., Usheva,A. and Bachvarov,D.
     In vivo DNase I-mediated footprinting analysis along the human bradykinin B1 receptor (BDKRB1) gene promoter: evidence for cell-specific regulation
[3] Feng,D.M., Wai,J.M., Kuduk,S.D., Ng,C., Murphy,K.L., Ransom,R.W., Reiss,D., Chang,R.S., Harrell,C.M., MacNeil,T., Tang,C.,, et al.
     2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists
[4] Prat,A., Biernacki,K., Saroli,T., Orav,J.E., Guttmann,C.R., Weiner,H.L., Khoury,S.J. and Antel,J.P.
     Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability
[5] Liesmaa,I., Kuoppala,A., Shiota,N., Kokkonen,J.O., Kostner,K., Mayranpaa,M., Kovanen,P.T. and Lindstedt,K.A.
     Increased expression of bradykinin type-1 receptors in endothelium of intramyocardial coronary vessels in human failing hearts
[6] , Menke J.G., Borkowski J.A., Bierilo K.K., Macneil T., Derrick A.W., Schneck K.A., Ransom R.W., Strader C.D., Linemeyer D.L., Hess J.F., et al.
     Expression cloning of a human B1 bradykinin receptor.
[7] , Yang X., Polgar P.
     Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions.
[8] , Bachvarov D.R., Hess J.F., Menke J.G., Larrivee J.F., Marceau F.
     Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1).
[9] , Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M., Docherty R.J., Webb M., Bevan S.J., McIntyre P., et al.
     Molecular characterisation of cloned bradykinin B1 receptors from rat and human.
[10] , Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y., et al.
     Genome-wide discovery and analysis of human seven transmembrane helix receptor genes.

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Precautions: BDKRB1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of BDKRB1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about BDKRB1 antibody, all related information, articles, resources about BDKRB1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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