CCR7 antibody, C-C chemokine receptor type 7 Antibody, Rabbit Polyclonal Antibody

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C-C chemokine receptor type 7 Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-461-10185

Buy CCR7 antibody -

Volume:

Related Product Names:

- CCR7 antibody; CCR7; CMKBR7; EBI1; EVI1; BLR2; CD197; C-C chemokine receptor type 7
- C-C CKR-7; CC-CKR-7; CCR-7; MIP-3 beta receptor; EBV-induced G-protein coupled receptor 1; EBI1; BLR2; CD197 antigen; CDw197; Chemokine (C-C motif) receptor 7

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: CCR7	Gene Name Synonym: CMKBR7; EBI1; EVI1; BLR2; CD197
Gi #: 4502641	NCBI Acc #: NP_001829.1	Swiss Prot Acc #: P32248
Length (aa): 378	Mol. Weight (Da): 42874	Chrom Location: 17q12-q21.2

Immunogen: 1st extracellular domain of human. Synthetic peptide - KLH conjugated.

Uses: IHC (18 ug/ml) (Optimal dilution to be determined by the researcher)

Source/Host: Rabbit

Purity/Purification: Immunoaffinity Purified

Clonality: Polyclonal

Crossreactivity: Human

Format: Phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

Storage: -4 degree C for short term (weeks) and -70 degree C for long term.

Stability: 6-12 months at -20 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for CCR7 ANTIBODY:

IHC: Tested

ELISA, ICC, Western Blot: Not Tested

TESTING: (secondary reagents and protocols )

IHC: Lymph Node ( anti-CCR7 )

CCR7 antibody IHC image
CCR7

CCR7 ANTIBODY TARGET DESCRIPTION:

Synonym Names for CCR7 antibody: CCR7; CMKBR7; EBI1; EVI1; BLR2; CD197; C-C CKR-7; CC-CKR-7; CCR-7; MIP-3 beta receptor; EBV-induced G-protein coupled receptor 1; EBI1; BLR2; CD197 antigen; CDw197; Chemokine (C-C motif) receptor 7

Function: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Subcellular Location: Membrane; multi-pass membrane protein.

Tissue Specificity: Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Induction: By EBV.

Similarity: Belongs to the G-protein coupled receptor 1 family [view classification].

Summary: The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.

C-C chemokine receptor type 7 reacts with human.

OMIM: 600242; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Cytokine-cytokine receptor interaction 04060

Products similar to CCR7 antibody:

IgG

EVI1 (ecotropic viral integration site 1), IgG

C-C chemokine receptor type 7, IgG

MDS1 (myelodysplasia syndrome 1), IgG

C-C chemokine receptor type 7, IgG

EVI1 (ecotropic viral integration site 1), IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for CCR7 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Fritsch,R.D., Shen,X., Sims,G.P., Hathcock,K.S., Hodes,R.J. and Lipsky,P.E.
     Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27
[2] Kim,J.W., Ferris,R.L. and Whiteside,T.L., et al.
     Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosis
[3] Parmiani,G., Castelli,C. and Rivoltini,L., et al.
     Chemokine receptor 7, a new player in regulating apoptosis of CD8+ T cells in cancer patients
[4] Cabioglu,N., Yazici,M.S., Arun,B., Broglio,K.R., Hortobagyi,G.N., Price,J.E. and Sahin,A.
     CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer
[5] Minetti,C., Gattorno,M., Repetto,S., Gregorio,A., Pedemonte,M., Assereto,S., Zara,F., Bruno,C. and Martini,A.
     Chemokine receptor CCR7 is expressed in muscle fibers in juvenile dermatomyositis
[6] , Birkenbach M.P., Josefsen K., Yalamanchili R.R., Lenoir G.M., Kieff E.
     Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.
[7] , Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W.
     Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2.
[8] , Kopatz S.A., Aronstam R.S., Sharma S.V.
     cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).
[9] , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
     Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

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Precautions: CCR7 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of CCR7 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CCR7 antibody, all related information, articles, resources about CCR7 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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