PTGFR antibody, Prostaglandin F2-alpha receptor anti-Human Antibody, Rabbit Polyclonal Antibody

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Prostaglandin F2-alpha receptor anti-Human Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-461-10320

Buy PTGFR antibody -

Volume:

Related Product Names:

- PTGFR antibody; PTGFR; FP; MGC46203; MGC120498; Prostaglandin F2-alpha receptor anti-Human
- Prostanoid FP receptor; PGF receptor; PGF2 alpha receptor; Prostaglandin F receptor isoform a

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: PTGFR	Gene Name Synonym: FP; MGC46203; MGC120498
Gi #: 4506261	NCBI Acc #: NP_000950.1	Swiss Prot Acc #: P43088
Length (aa): 359	Mol. Weight (Da): 40055	Chrom Location: 1p31.1

Immunogen: 2nd extracellular domain of human. Synthetic peptide - KLH conjugated.

Uses: IHC (4 - 8 ug/ml), ICC (Optimal dilution to be determined by the researcher)

Concentration: 1 mg/ml

Source/Host: Rabbit

Purity/Purification: Peptide immunogen affinity column

Clonality: Polyclonal

Crossreactivity: Human

Format: Phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

Storage: +4 degree C for short term (weeks) and -70 degree C for long term.

Stability: 6-12 months at -20 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for PTGFR ANTIBODY:

ICC, IHC: Tested

ELISA, Western Blot: Not Tested

TESTING: (secondary reagents and protocols )

ICC: Transfection - cells expressing target protein ( anti-PTGFR )

PTGFR antibody ICC image
PTGFR

ICC: Transfection - cells expressing vector only ( anti-PTGFR )

PTGFR antibody ICC image
PTGFR

PTGFR ANTIBODY TARGET DESCRIPTION:

Synonym Names for PTGFR antibody: PTGFR; FP; MGC46203; MGC120498; Prostanoid FP receptor; PGF receptor; PGF2 alpha receptor; Prostaglandin F receptor isoform a

Function: Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity).

Subcellular Location: Membrane; multi-pass membrane protein.

Similarity: Belongs to the G-protein coupled receptor 1 family [view classification].

Summary: The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene.

Prostaglandin F2-alpha receptor anti-Human reacts with human.

OMIM: 600563; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Calcium signaling pathway 04020
KEGG pathway: Neuroactive ligand-receptor interaction 04080

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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for PTGFR ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Chen,X.B. and Regan,J.W., et al.
     Activation of the human FP prostanoid receptor disrupts mitosis progression and generates aneuploidy and polyploidy
[2] Hebert,R.L., Carmosino,M., Saito,O., Yang,G., Jackson,C.A., Qi,Z., Breyer,R.M., Natarajan,C., Hata,A.N., Zhang,Y., Guan,Y. and, et al.
     Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct
[3] Mandal,A.K., Ray,R., Zhang,Z., Chowdhury,B., Pattabiraman,N. and Mukherjee,A.B.
     Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators
[4] Scott,G., Jacobs,S., Leopardi,S., Anthony,F.A., Learn,D., Malaviya,R. and Pentland,A.
     Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation
[5] Sugino,N., Karube-Harada,A., Taketani,T., Sakata,A. and Nakamura,Y., et al.
     Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation
[6] , Abramovitz M., Boie Y., Nguyen T., Rushmore T.H., Bayne M.A., Metters K.M., Slipetz D.M., Grygorczyk R.
     Cloning and expression of a cDNA for the human prostanoid FP receptor.
[7] , Kunapuli P., Lawson J.A., Hwang S.W., Adiyaman M., Khanapure S.P., Rokach J., Fitzgerald G.A.
     Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
[8] , Kopatz S.A., Aronstam R.S., Sharma S.V.
     cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).
[9] , Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., et al.
     The DNA sequence and biological annotation of human chromosome 1.
[10] , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
     Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

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Precautions: PTGFR antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of PTGFR antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about PTGFR antibody, all related information, articles, resources about PTGFR antibody are being stored on our online database. Let us know if you have questions regarding this product.

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