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| P2Y purinoceptor 12 Antibody, Rabbit Polyclonal Antibody |
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| Catalog Number: 18-461-10482 |
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| Related Product Names:
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P2RY12 antibody; P2RY12; HORK3; P2Y12; ADPG-R; SP1999; P2T(AC); P2Y(AC); P2Y(ADP); P2Y purinoceptor 12
- P2Y12; P2Y12 platelet ADP receptor; P2Y(ADP); ADP-glucose receptor; ADPG-R; P2Y(AC); P2Y(cyc); P2T(AC); SP1999; Purinergic receptor P2Y12 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: P2RY12 |
Gene Name Synonym: HORK3; P2Y12; ADPG-R; SP1999; P2T(AC); P2Y(AC); P2Y(ADP) |
Gi #:
12232483 |
NCBI Acc #:
NP_073625.1 |
Swiss Prot Acc #:
Q9H244 |
Length (aa): 342 |
Mol. Weight (Da): 39439 |
Chrom Location: 3q24-q25 |
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 Immunogen: N-terminal extracellular domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (32 ug/ml), ICC (Optimal dilution to be determined by the researcher)
Source/Host: Rabbit
Purity/Purification: Immunoaffinity Purified
Clonality: Polyclonal
Crossreactivity: Human
Format: Phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
Storage: -4 degree C for short term (weeks) and -70 degree C for long term.
Stability: 6-12 months at -20 degree C.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for P2RY12 ANTIBODY: |
| ICC, IHC: Tested |
| ELISA, Western Blot: Not Tested |
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| TESTING: (secondary reagents and protocols
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IHC: Blood, Platelets ( anti-P2RY12 )P2RY12 antibody IHC image
 ICC: Transfection - cells expressing target protein ( anti-P2RY12 )P2RY12 antibody ICC image
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| P2RY12 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for P2RY12 antibody: P2RY12; HORK3; P2Y12; ADPG-R; SP1999; P2T(AC); P2Y(AC); P2Y(ADP); P2Y12; P2Y12 platelet ADP receptor; P2Y(ADP); ADP-glucose receptor; ADPG-R; P2Y(AC); P2Y(cyc); P2T(AC); SP1999; Purinergic receptor P2Y12
Function: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation.
Subcellular Location: Membrane; multi-pass membrane protein.
Tissue Specificity: Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.
Disease: Defects in P2RY12 are a cause of bleeding disorder [MIM:609821].
Similarity: Belongs to the G-protein coupled receptor 1 family [view classification].
Summary: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.
P2Y purinoceptor 12 reacts with human.
OMIM: 600515; gene. [NCBI / EBI]
609821; phenotype. [NCBI / EBI]
Products similar to P2RY12 antibody:
IgG
 P2Y purinoceptor 12, IgG
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for P2RY12 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
[1] Nonaka,Y., Hiramoto,T. and Fujita,N., et al.
Identification of endogenous surrogate ligands for human P2Y12 receptors by in silico and in vitro methods
[2] Hardy,A.R., Hill,D.J. and Poole,A.W., et al.
Evidence that the purinergic receptor P2Y12 potentiates platelet shape change by a Rho kinase-dependent mechanism
[3] Ziegler,S., Schillinger,M., Funk,M., Felber,K., Exner,M., Mlekusch,W., Sabeti,S., Amighi,J., Minar,E., Brunner,M., Muller,M., et al.
Association of a functional polymorphism in the clopidogrel target receptor gene, P2Y12, and the risk for ischemic cerebrovascular events in patients with peripheral artery disease
[4] van der Meijden,P.E., Feijge,M.A., Giesen,P.L., Huijberts,M., van Raak,L.P. and Heemskerk,J.W.
Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk
[5] Hardy,A.R., Conley,P.B., Luo,J., Benovic,J.L., Poole,A.W. and Mundell,S.J.
P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms
[6] , Hollopeter G., Jantzen H.-M., Vincent D., Li G., England L., Ramakrishnan V., Yang R.-B., Nurden P., Nurden A., Julius D.J., et al.
Identification of the platelet ADP receptor targeted by antithrombotic drugs.
[7] , Zhang F.L., Luo L., Gustafson E., Lachowicz J., Smith M., Qiao X., Liu Y.-H., Chen G., Pramanik B., Laz T.M., et al.
ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999.
[8] , Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S., Ohishi T., Soga T., Matsushime H., Furuichi K.
Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y1 receptor.
[9] , Reinscheid R.K., Nothacker H.-P., Wang Z., Zeng J., Ehlert F.J., Civelli O.
ADP-glucose activates a G-protein coupled receptor and inhibits smooth muscle contractions.
[10] , Bruess M., von Kugelgen I., Bonisch H.
Cloning and characterization of a human platelet ADP-receptor. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: P2RY12 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of P2RY12 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about P2RY12 antibody, all related information, articles, resources about P2RY12 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. This product has been manufactured by MBL International. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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