GCGR antibody, Glucagon receptor Antibody, Rabbit Polyclonal Antibody

Alphabetical Listing of Primary Antibodies:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

Glucagon receptor Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-461-10625

Buy GCGR antibody -

Volume:

Related Product Names:

- GCGR antibody; GCGR; GGR; MGC138246; Glucagon receptor
- GL-R; Glucagon receptor

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: GCGR	Gene Name Synonym: GGR; MGC138246
Gi #: 4503947	NCBI Acc #: NP_000151.1	Swiss Prot Acc #: P47871
Length (aa): 477	Mol. Weight (Da): 54009	Chrom Location: 17q25

Immunogen: 1st extracellular domain of human. Synthetic peptide - KLH conjugated.

Uses: IHC (7 ug/ml) (Optimal dilution to be determined by the researcher)

Source/Host: Rabbit

Purity/Purification: Immunoaffinity Purified

Clonality: Polyclonal

Crossreactivity: Human

Format: Phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

Storage: -4 degree C for short term (weeks) and -70 degree C for long term.

Stability: 6-12 months at -20 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for GCGR ANTIBODY:

IHC: Tested

ELISA, ICC, Western Blot: Not Tested

TESTING: (secondary reagents and protocols )

IHC: Adipocytes ( anti-GCGR )

GCGR antibody IHC image
GCGR

GCGR ANTIBODY TARGET DESCRIPTION:

Synonym Names for GCGR antibody: GCGR; GGR; MGC138246; GL-R; Glucagon receptor

Function: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

Subcellular Location: Membrane; multi-pass membrane protein.

Disease: It is a candidate for certain defects in non-insulin-dependent diabetes mellitus (NIDDM). The variant in position 40 (Ser) is found in some NIDDM patients, but also in nondiabetic subjects.

Similarity: Belongs to the G-protein coupled receptor 2 family [view classification].

Summary: The physiologic effects of glucagon (GCG; MIM 138030) are mediated through the glucagon receptor, a member of the superfamily of receptors characterized by a 7-transmembrane domain structure and by their coupling via GTP-binding proteins (G proteins) to adenyl cyclase.[supplied by OMIM].

Glucagon receptor reacts with human.

OMIM: 138033; gene. [NCBI / EBI]

Products similar to GCGR antibody:

IgG

Filaggrin [FLG01], IgG

Glucagon receptor, IgG

Filaggrin [SPM181] (ready-to-use), IgG

Glucagon receptor, IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for GCGR ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Runge,S., Gram,C., Brauner-Osborne,H., Madsen,K., Knudsen,L.B. and Wulff,B.S.
     Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus
[2] Shiota,D., Kasamatsu,T., Dib,S.A., Chacra,A.R. and Moises,R.S., et al.
     Role of the Gly40Ser mutation in the glucagon receptor gene in Brazilian patients with type 2 diabetes mellitus
[3] Strazzullo,P., Iacone,R., Siani,A., Barba,G., Russo,O., Russo,P., Barbato,A., D'Elia,L., Farinaro,E. and Cappuccio,F.P.
     Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant
[4] Yamato,E., Ikegami,H., Takekawa,K., Fujisawa,T., Nakagawa,Y., Hamada,Y., Ueda,H. and Ogihara,T.
     Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1)
[5] Chambers,S.M. and Morris,B.J., et al.
     Glucagon receptor gene mutation in essential hypertension
[6] , Macneil D.J., Occi J.L., Hey P.J., Strader C.D., Graziano M.P.
     Cloning and expression of a human glucagon receptor.
[7] , Lok S., Kuijper J.L., Jelinek L.J., Kramer J.M., Whitmore T.E., Sprecher C.A., Mathewes S., Grant F.J., Biggs S.H., Rosenberg G.B., et al.
     The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization.
[8] , Menzel S., Stoffel M., Espinosa R. III, Fernald A.A., Le Beau M.M., Bell G.I.
     Localization of the glucagon receptor gene to human chromosome band 17q25.
[9] , Fujisawa T., Ikegami H., Yamato E., Takekawa K., Nakagawa Y., Hamada Y., Ueda H., Fukuda M., Ogihara T.
     A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: GCGR antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of GCGR antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about GCGR antibody, all related information, articles, resources about GCGR antibody are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. This product has been manufactured by MBL International.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved