DRD5 antibody, D(1B) dopamine receptor Antibody, Rabbit Polyclonal Antibody

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D(1B) dopamine receptor Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-461-10678

Buy DRD5 antibody -

Volume:

Related Product Names:

- DRD5 antibody; DRD5; DRD1B; DBDR; DRD1L2; D(1B) dopamine receptor
- D(5) dopamine receptor; D1beta dopamine receptor; Dopamine receptor D5

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: DRD5	Gene Name Synonym: DRD1B; DBDR; DRD1L2
Gi #: 4503391	NCBI Acc #: NP_000789.1	Swiss Prot Acc #: P21918
Length (aa): 477	Mol. Weight (Da): 52951	Chrom Location: 4p16.1

Epitope: 3rd extracellular domain of human. Synthetic peptide - KLH conjugated.

Target Protein: Dopamine Receptor D5

Family: GPCR

Subfamily: Dopamine

Uses: IHC (3.4 ug/ml) (Optimal dilution to be determined by the researcher)

Summary of Expression: DRD5 has been reported to be expressed in various regions of the brain, as well as in artery, eye, ganglion, kidney, small intestine, spleen, stomach and thymus. ESTs have been isolated from human normal brain and eye libraries and from a colon carcinoma library.

Ligand: Dopamine

Source/Host: Rabbit

Purity/Purification: Peptide immunogen affinity column

Clonality: Polyclonal

Crossreactivity: Human

Format: Phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

Storage: +4 degree C for short term (weeks) and -70 degree C for long term.

Stability: 6-12 months at -20 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for DRD5 ANTIBODY:

IHC: Tested

ELISA, ICC, Western Blot: Not Tested

TESTING: (secondary reagents and protocols )

IHC: Rat brain, Purkinje neurons ( anti-DRD5 )

DRD5 antibody IHC image
DRD5

DRD5 ANTIBODY TARGET DESCRIPTION:

Synonym Names for DRD5 antibody: DRD5; DRD1B; DBDR; DRD1L2; D(5) dopamine receptor; D1beta dopamine receptor; Dopamine receptor D5

Function: This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular Location: Membrane; multi-pass membrane protein.

Tissue Specificity: Neuron-specific, localized primarily within limbic regions of the brain.

Disease: Defects in DRD5 may be a cause of schizophrenia, but no proof has yet been found.

Disease: Defects in DRD5 are a cause of blepharospasm [MIM:606798]. It is a primary focal dystonia affecting the orbicularis oculi muscles, usually beginning in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. In severe cases, this can lead to functional blindness.

Similarity: Belongs to the G-protein coupled receptor 1 family [view classification].

Summary: This protein is the D5 subtype of the dopamine receptor The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2.

D(1B) dopamine receptor reacts with human.

OMIM: 126453; gene+phenotype. [NCBI / EBI]
606798; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Neuroactive ligand-receptor interaction 04080

Products similar to DRD5 antibody:

IgG

DRD5, IgG

Rabbit anti D5 Dopamine Rec., IgG

Rabbit anti D5 Dopamine Recept, IgG

D5 Dopamine Receptor, Peptide

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for DRD5 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Yang,Z., Asico,L.D., Yu,P., Wang,Z., Jones,J.E., Escano,C.S., Wang,X., Quinn,M.T., Sibley,D.R., Romero,G.G., Felder,R.A. and, et al.
     D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure
[2] Hawi,Z., Segurado,R., Conroy,J., Sheehan,K., Lowe,N., Kirley,A., Shields,D., Fitzgerald,M., Gallagher,L. and Gill,M.
     Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder
[3] Kustanovich,V., Ishii,J., Crawford,L., Yang,M., McGough,J.J., McCracken,J.T., Smalley,S.L. and Nelson,S.F.
     Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5
[4] Mill,J., Curran,S., Richards,S., Taylor,E. and Asherson,P., et al.
     Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD
[5] Misbahuddin,A., Placzek,M.R. and Warner,T.T., et al.
     Focal dystonia is associated with a polymorphism of the dopamine D5 receptor gene
[6] , Sunahara R.K., Guan H.-C., O'Dowd B.F., Seeman P., Laurier L.G., Ng G., George S.R., Torchia J., van Tol H.H.M., Niznik H.B., et al.
     Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
[7] , Grandy D.K., Zhang Y., Bouvier C., Zhou Q.-Y., Johnson R.A., Allen L., Buck K., Bunzow J.R., Salon J., Civelli O., et al.
     Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.
[8] , Weinshank R.L., Adham N., Macchi M., Olsen M.A., Branchek T.A., Hartig P.R.
     Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.
[9] , Puhl H.L. III, Ikeda S.R., Aronstam R.S.
     cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).
[10] , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
     Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

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Precautions: DRD5 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of DRD5 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about DRD5 antibody, all related information, articles, resources about DRD5 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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