ADAMTS4 antibody, ADAMTS-4 Antibody, Rabbit Polyclonal Antibody

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ADAMTS-4 Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-461-10824

Buy ADAMTS4 antibody -

Volume:

Related Product Names:

- ADAMTS4 antibody; ADAMTS4; KIAA0688; ADMP-1; ADAMTS-2; ADAMTS-4; ADAMTS-4
- EC 3.4.24.82; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS 4; ADAM-TS4; Aggrecanase-1; ADMP-1; ADAM metallopeptidase with thrombospondin type 1 motif, 4 preproprotein

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: ADAMTS4	Gene Name Synonym: KIAA0688; ADMP-1; ADAMTS-2; ADAMTS-4
Gi #: 41327756	NCBI Acc #: NP_005090.2	Swiss Prot Acc #: O75173
Length (aa): 837	Mol. Weight (Da): 90225	Chrom Location: 1q21-q23

Target Protein: A Disintegrin-like and Metalloportease with Thrombospondin Type 1 Motif 4 (ADAMTS4)

Sub Family: Metallopeptidase M12B

Immunogen: Synthetic peptide - KLH conjugated.

Epitode: Disintegrin-like domain of human.

Uses: IHC (2 ug/ml) (Optimal dilution to be determined by the researcher)

Summary of Expression: ADAMTS4 expression has been documented in normal human brain, cartilage, heart, lung, placenta, muscle, and synovium. ESTs have been isolated from human tissue libraries, including normal brain, lung, pancreas, and skeletal muscle and cancerous breast.

Source/Host: Rabbit

Purity/Purification: Peptide immunogen affinity column

Clonality: Polyclonal

Crossreactivity: Human

Format: Phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.

Storage: -4 degree C for short term (weeks) and -70 degree C for long term.

Stability: 6-12 months at -20 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for ADAMTS4 ANTIBODY:

IHC: Tested

ELISA, ICC, Western Blot: Not Tested

TESTING: (secondary reagents and protocols )

IHC: Cartilage ( anti-ADAMTS4 )

ADAMTS4 antibody IHC image
ADAMTS4

ADAMTS4 ANTIBODY TARGET DESCRIPTION:

Synonym Names for ADAMTS4 antibody: ADAMTS4; KIAA0688; ADMP-1; ADAMTS-2; ADAMTS-4; EC 3.4.24.82; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS 4; ADAM-TS4; Aggrecanase-1; ADMP-1; ADAM metallopeptidase with thrombospondin type 1 motif, 4 preproprotein

Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the 392-Glu-|-Ala-393 site.

Catalytic Activity: Glutamyl endopeptidase; bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan.

Cofactor: Binds 1 zinc ion per subunit (By similarity).

Subcellular Location: Secreted protein; extracellular space; extracellular matrix (By similarity).

Tissue Specificity: Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles.

Induction: By interleukin-1.

Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.

Ptm: The precursor is cleaved by a furin endopeptidase.

Similarity: Contains 1 disintegrin domain.

Similarity: Contains 1 peptidase M12B domain [view classification].

Similarity: Contains 1 TSP type-1 domain.

Summary: This protein is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

ADAMTS-4 reacts with human.

OMIM: 603876; gene. [NCBI / EBI]

Products similar to ADAMTS4 antibody:

IgG

ADAMTS4, IgG

ADAMTS3, IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for ADAMTS4 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Thirunavukkarasu,K., Pei,Y., Moore,T.L., Wang,H., Yu,X.P., Geiser,A.G. and Chandrasekhar,S.
     Regulation of the human ADAMTS-4 promoter by transcription factors and cytokines
[2] Hatano,E., Fujita,T., Ueda,Y., Okuda,T., Katsuda,S., Okada,Y. and Matsumoto,T.
     Expression of ADAMTS-4 (aggrecanase-1) and possible involvement in regression of lumbar disc herniation
[3] Held-Feindt,J., Paredes,E.B., Blomer,U., Seidenbecher,C., Stark,A.M., Mehdorn,H.M. and Mentlein,R.
     Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas
[4] Yoshida,K., Suzuki,Y., Saito,A., Fukuda,K., Hamanishi,C. and Munakata,H.
     Aggrecanase-1 (ADAMTS-4) interacts with alpha1-antitrypsin
[5] Hashimoto,G., Shimoda,M. and Okada,Y., et al.
     ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan
[6] , Tortorella M.D., Burn T.C., Pratta M.A., Abbaszade I., Hollis J.M., Liu R.-Q., Rosenfeld S.A., Copeland R.A., Decicco C.P., Wynn R., et al.
     Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
[7] , Sawaji Y., Nagase H., Saklatvala J., Clark A.R.
     ADAMTS-4 genomic locus.
[8] , Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
     Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
[9] , Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., et al.
     The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
[10] , Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., et al.
     The DNA sequence and biological annotation of human chromosome 1.

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Precautions: ADAMTS4 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of ADAMTS4 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ADAMTS4 antibody, all related information, articles, resources about ADAMTS4 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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