Alphabetical Listing of Primary Antibodies:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
f
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0-4
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5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
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Secondary Antibodies
|
ELISA Kits
Baculoviral IAP repeat-containing protein 5 Antibody, Rabbit Polyclonal Antibody
Catalog Number: 18-661-15084
Buy BIRC5 antibody -
Size:
1 mg ($1,560.00)
0.5 mg ($1,050.00)
0.1 mg ($300.00)
Related Product Names:
- BIRC5 antibody; BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5
- Apoptosis inhibitor survivin; Apoptosis inhibitor 4; Baculoviral IAP repeat-containing protein 5 isoform 3
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
BIRC5
Gene Name Synonym:
API4; IAP4
Gi #:
59859882
NCBI Acc #:
NP_001012271.1
Swiss Prot Acc #:
O15392
Length (aa):
165
Mol. Weight (Da):
16389
Chrom Location:
17q25
Linear Protein Map with Immunogenic Epitope Marked (sequence source from above GI#)
Source/Host:
Rabbit
Purity/Purification:
It is supplied as immunoaffinity chromatography purified IgG.
Clonality:
Polyclonal
Crossreactivity:
Mouse
Format:
Phosphate-Buffered Saline, containing 0.02% sodium azide.
Storage:
4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.
Stability:
Store at -4 degree C for one year.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for BIRC5 ANTIBODY:
WB: Tested
ELISA, ICC, IHC: Not Tested
TESTING: (
secondary reagents
and
protocols
)
Western Blot:
Western blot analysis of survivin in mouse spleen tissue lysate with anti-survivin (CT) at 1 ug/ml. ( anti-BIRC5 )
BIRC5 antibody Western Blot image
BIRC5 ANTIBODY TARGET DESCRIPTION:
Synonym Names for BIRC5 antibody:
BIRC5; API4; IAP4; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; Baculoviral IAP repeat-containing protein 5 isoform 3
Function:
May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Interacts with tubulin. Inhibitor of caspase-3 and caspase-7.
Subunit:
Homodimer. When phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas.
Domain:
The BIR repeat is necessary and sufficient for HBXIP binding.
Similarity:
Belongs to the IAP family.
Similarity:
Contains 1 BIR repeat.
Summary:
This protein is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
Baculoviral IAP repeat-containing protein 5 reacts with mouse.
OMIM:
603352; gene. [
NCBI
/
EBI
]
Pathways:
KEGG pathway: Colorectal cancer
05210
Products similar to BIRC5 antibody:
IgG
SURVIVIN, IgG
SURVIVIN, IgG
Baculoviral IAP repeat-containing protein 5, IgG
Rabbit anti Survivin, IgG
SURVIVIN, IgG
PRODUCT INTERACTIONS:
Baculoviral IAP repeat-containing protein 5
interacts
with
Caspase-9, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
Caspase-9, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
CASPASE-9, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
CASPASE-9, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
CASPASE-9, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
CASPASE-9, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
Caspase 9 [1-2], IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
Caspase 9 active, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
Caspase 9, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
Caspase 9, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
Rabbit A' Caspase 9 (I20)(Intermed. Domain2), IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
Rabbit A' Caspase 9 (I16)Intermed. Domain 1, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
Rabbit anti Human Caspase 9, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
Caspase 9 active, IgG
(GenWay Catalog #: 18-661-15084)
.
Baculoviral IAP repeat-containing protein 5
interacts
with
Caspase 9 (ready-to-use), IgG
(GenWay Catalog #: 18-661-15084)
.
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
BACKGROUND REFERENCES for BIRC5 ANTIBODY:
Background references for antibody target are not specific to GenWay products
[1]
Zhu,N., Gu,L., Findley,H.W., Chen,C., Dong,J.T., Yang,L. and Zhou,M.
KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia
[2]
Sato,A., Oya,M., Ito,K., Mizuno,R., Horiguchi,Y., Umezawa,K., Hayakawa,M. and Murai,M.
Survivin associates with cell proliferation in renal cancer cells: regulation of survivin expression by insulin-like growth factor-1, interferon-gamma and a novel NF-kappaB inhibitor
[3]
Dohi,T., Salz,W., Costa,M., Ariyan,C., Basadonna,G.P. and Altieri,D.C.
Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice
[4]
Rosa,J., Canovas,P., Islam,A., Altieri,D.C. and Doxsey,S.J., et al.
Survivin modulates microtubule dynamics and nucleation throughout the cell cycle
[5]
Deng,H., Wu,R.L., Zhou,H.Y., Huang,X., Chen,Y. and Liu,L.J., et al.
Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer
[6]
, Ambrosini G., Adida C., Altieri D.C.
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.
[7]
, Uren A.G., Vaux D.L.
Mammalian inhibitor of apoptosis (IAP) homolog.
[8]
, Kageyama H., Islam A., Takayasu H., Nakagawara A.
An isoform of survivin (survivin-beta) which has 23 amino acids insertion into the BIR domain.
[9]
, Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Nguyen D.A., Poel C.L., Chambers S.W., Schackwitz W.S., et al.
NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).
[10]
, Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
BIRC5 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of BIRC5 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about BIRC5 antibody, all related information, articles, resources about BIRC5 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.
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