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| Mitogen-activated protein kinase kinase kinase 7 Antibody, Rabbit polyclonal TAK1 antibody was raised against a synthetic p Polyclonal Antibody |
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| Catalog Number: 18-661-15207 |
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| Related Product Names:
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MAP3K7 antibody; MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7
- EC 2.7.11.25; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1; TGF-beta activated kinase 1a |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: MAP3K7 |
Gene Name Synonym: TAK1 |
Gi #:
2924624 |
NCBI Acc #:
BAA25025.1 |
Swiss Prot Acc #:
O43318 |
Length (aa): 579 |
Mol. Weight (Da): 67196 |
Chrom Location: N/A |
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 Immunogen: Raised against a synthetic peptide corresponding to 14 amino acids near the amino-terminus of human TAK1 isoform a.
Application: TAK1 antibody can be used for the detection of TAK1 by Western blot at 0.5 to 1 ?g/ml. (Optimal dilution should be determined by user.) Rat thymus cell lysate can be used as positive control. TAK1 antibody is human, mouse, and rat reactive. This product is for research use only.
Background: TAK1 (TGF-&betta; activated protein kinase 1) is a widely expressed enzyme originally identified as a mitogen-activated protein kinase kinase kinase (MAP3K7) (1). It has since been shown to mediate various intracellular signaling pathways, such as those induced by TGF-? and members of the Toll-IL-1R (TIR) superfamily (2), thus acting as an intermediate in both proliferative and innate and adaptive immune responses (3). TAK1 is normally present in cells in a complex with TAK1-binding protein 1 (TAB1) and either TAB2 or TAB3 (4,5). Association with TAB1 triggers TAK1 kinase activity by inducing TAK1 autophosphorylation (6), while TAB2 and possibly TAB3 may contribute to SAPK2a/p38a-mediated feedback inhibition of TAK1 activity (5).
Source/Host: Rabbit polyclonal TAK1 antibody was raised against a synthetic p
Purity/Purification: It is supplied as immunoaffinity purified IgG.
Clonality: Polyclonal
Crossreactivity: Human, mouse, rat
Format: Phosphate-Buffered Saline, containing 0.02% sodium azide.
Storage: TAK1 antibody is supplied as immunoaffinity purified IgG in PBS containing 0.02% sodium azide. Store at 4°C, stable for one year.
Stability: Store at -4 degree C for one year.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for MAP3K7 ANTIBODY: |
| WB: Tested |
| ELISA, ICC, IHC: Not Tested |
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| TESTING: (secondary reagents and protocols
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Western Blot: Western blot analysis of TAK1 in Rat thymus cell lysate with anti-TAK1 at (A) 1, (B) 2, and (C) 4 ug/ml. ( anti-MAP3K7 )MAP3K7 antibody Western Blot image
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| MAP3K7 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for MAP3K7 antibody: MAP3K7; TAK1; EC 2.7.11.25; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1; TGF-beta activated kinase 1a
Function: Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF-kappa-B activation and the p38 MAPK pathway.
Catalytic Activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Magnesium.
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L.
Similarity: Belongs to the Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Similarity: Contains 1 protein kinase domain.
Mitogen-activated protein kinase kinase kinase 7 reacts with human, mouse, rat.
OMIM: 602614; gene. [NCBI / EBI]
Products similar to MAP3K7 antibody:
IgG
 MAP3K7IP3, IgG
TAK1, IgG
TAK1 / MAP3K7, IgG
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, IgG
MAP3K7IP3, IgG
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| PRODUCT INTERACTIONS: |
Mitogen-activated protein kinase kinase kinase 7 interacts with IkappaB kinase complex-associated protein, IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with IkappaB kinase complex-associated protein, IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with Rabbit anti IKAP, IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3 Human, Protein (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with Signal transducer and activator of transcription 3, Protein (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with signal transducer and activator of transcription 3 (acute-phase response factor), IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3, IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3 phospho Y705, IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3, IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3 (Phospho-Tyr705), IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3 (Phospho-Ser727), IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3 (Ab-705), IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3 (Ab-727), IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3 (Phospho-Tyr705) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3 (Phospho-Ser727) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with phospho-Stat3 (Y705), IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3 (ready-to-use), IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3, IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with Phospho Stat-3 (pS727), IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with Stat3, IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3 Phospho (pY705), IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with Stat-3, IgG (GenWay Catalog #: 18-661-15207).
Mitogen-activated protein kinase kinase kinase 7 interacts with STAT3, pSer 727, IgG (GenWay Catalog #: 18-661-15207).
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for MAP3K7 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
[1] Sakurai,H., Shigemori,N., Hasegawa,K. and Sugita,T., et al.
TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism
[2] Sakurai,H., et al.
Direct Submission
[3] , Sakurai H., Shigemori N., Hasegawa K., Sugita T.
TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.
[4] , Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., et al.
The DNA sequence and analysis of human chromosome 6.
[5] , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
[6] , Shibuya H., Yamaguchi K., Shirakabe K., Tonegawa A., Gotoh Y., Ueno N., Irie K., Nishida E., Matsumoto K.
TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.
[7] , Jensen L.E., Whitehead A.S.
Pellino2 activates the mitogen activated protein kinase pathway.
[8] , Jensen L.E., Whitehead A.S.
Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.
[9] , Edlund S., Bu S., Schuster N., Aspenstrom P., Heuchel R., Heldin N.E., ten Dijke P., Heldin C.H., Landstrom M.
Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: MAP3K7 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of MAP3K7 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about MAP3K7 antibody, all related information, articles, resources about MAP3K7 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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