MCL1 antibody, Induced myeloid leukemia cell differentiation protein Mcl-1 Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

Induced myeloid leukemia cell differentiation protein Mcl-1 Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-661-15230

Buy MCL1 antibody -

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Related Product Names:

- MCL1 antibody; MCL1; TM; EAT; MCL1L; MCL1S; MGC1839; MGC104264; Induced myeloid leukemia cell differentiation protein Mcl-1
- Bcl-2-related protein EAT/mcl1; mcl1/EAT; Myeloid cell leukemia sequence 1 isoform 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: MCL1	Gene Name Synonym: TM; EAT; MCL1L; MCL1S; MGC1839; MGC104264
Gi #: 11386165	NCBI Acc #: NP_068779.1	Swiss Prot Acc #: Q07820
Length (aa): 350	Mol. Weight (Da): 37337	Chrom Location: 1q21

Immunogen: Raised against a peptide corresponding to 16 amino acids near the center of human Mcl-1.

Source/Host: Rabbit

Purity/Purification: It is supplied as ion exchange chromatography purified IgG .

Clonality: Polyclonal

Crossreactivity: Human

Format: Phosphate-Buffered Saline, containing 0.02% sodium azide.

Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.

Stability: Store at -4 degree C for one year.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for MCL1 ANTIBODY:

WB: Tested

ELISA, ICC, IHC: Not Tested

TESTING: (secondary reagents and protocols )

Western Blot: Western blot analysis of Mcl-1 in Raji cell lysates with anti-Mcl-1 (IN) at (A) 0.5, (B) 1, and (C) 2 ug/ml. ( anti-MCL1 )

MCL1 antibody Western Blot image
MCL1

MCL1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for MCL1 antibody: MCL1; TM; EAT; MCL1L; MCL1S; MGC1839; MGC104264; Bcl-2-related protein EAT/mcl1; mcl1/EAT; Myeloid cell leukemia sequence 1 isoform 1

Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis while isoform 2 promotes it.

Subunit: Interacts with BAD, BOK, BIK, BFM and PMAIP (By similarity). Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptototic BCL2-related proteins.

Subcellular Location: Membrane; single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Cytoplasmic, associated with mitochondria. Nucleus; nucleoplasm.

Induction: Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat-shock induced differentiation. Expression increases early during retinoic acid-induced differentiation.

Ptm: Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.

Ptm: Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.

Ptm: Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.

Similarity: Belongs to the Bcl-2 family.

Summary: The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.

Induced myeloid leukemia cell differentiation protein Mcl-1 reacts with human.

OMIM: 159552; gene. [NCBI / EBI]

Products similar to MCL1 antibody:

IgG

GOAT ANTI HUMAN ASC, IgG

FAS [Alf2.1], IgG

ATM [5C2], IgG

APRIL, IgG

Integral membrane protein GPR137B, IgG

Peptide

Presenilin-2 N-terminal Peptide, Peptide

Thymosin beta4, Peptide

Stathmin 1 (Phospho-Ser24) Antibody Blocking Peptide, Peptide

Thymosin alpha1, Peptide

BNP (1-32) Human, Peptide

Protein

MMP-3 Human, Protein

YEATS domain-containing protein 4, Protein

ALPHA INTERFERON (CHO-DERIVED), Protein

MMP-3, Protein

Hypothetical protein tmp_locus_8, Protein

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for MCL1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Han,J., Goldstein,L.A., Gastman,B.R. and Rabinowich,H., et al.
     Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis
[2] Maurer,U., Charvet,C., Wagman,A.S., Dejardin,E. and Green,D.R., et al.
     Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
[3] Clohessy,J.G., Zhuang,J., de Boer,J., Gil-Gomez,G. and Brady,H.J., et al.
     Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis
[4] Fleischer,B., Schulze-Bergkamen,H., Schuchmann,M., Weber,A., Biesterfeld,S., Muller,M., Krammer,P.H. and Galle,P.R.
     Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma
[5] Sieghart,W., Losert,D., Strommer,S., Cejka,D., Schmid,K., Rasoul-Rockenschaub,S., Bodingbauer,M., Crevenna,R., Monia,B.P.,, et al.
     Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy
[6] , Kozopas K.M., Yang T., Buchan H.L., Zhou P., Craig R.W.
     MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.
[7] , Umezawa A., Maruyama T., Inazawa J., Imai S., Takano T., Hata J.
     Induction of mcl1/EAT, Bcl-2 related gene, by retinoic acid or heat shock in the human embryonal carcinoma cells, NCR-G3.
[8] , Akgul C., Turner P.C., White M.R.H., Edwards S.W.
     Functional analysis of the human MCL-1 gene.
[9] , Bingle C.D., Craig R.W., Swales B.M., Singleton V., Zhou P., Whyte M.K.B.
     Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death.
[10] , Bae J., Leo C.P., Hsu S.Y., Hsueh A.J.W.
     MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: MCL1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of MCL1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about MCL1 antibody, all related information, articles, resources about MCL1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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