FRAP1 antibody, FKBP12-rapamycin complex-associated protein Antibody, Rabbit Polyclonal Antibody

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FKBP12-rapamycin complex-associated protein Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-661-15231

Buy FRAP1 antibody -

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Related Product Names:

- FRAP1 antibody; FRAP1; FRAP; FRAP2; MTOR; RAFT1; FKBP12-rapamycin complex-associated protein
- FK506-binding protein 12-rapamycin complex-associated protein 1; Rapamycin target protein; RAPT1; Mammalian target of rapamycin; mTOR; FK506 binding protein 12-rapamycin associated protein 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: FRAP1	Gene Name Synonym: FRAP; FRAP2; MTOR; RAFT1
Gi #: 4826730	NCBI Acc #: NP_004949.1	Swiss Prot Acc #: P42345
Length (aa): 2549	Mol. Weight (Da): 288892	Chrom Location: 1p36.2

Immunogen: Raised against a 15 amino acid peptide from near the center of human TOR.

Source/Host: Rabbit

Purity/Purification: It is supplied as immunoaffinity purified IgG.

Clonality: Polyclonal

Crossreactivity: Human, mouse

Format: Phosphate-Buffered Saline, containing 0.02% sodium azide.

Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.

Stability: Store at -4 degree C for one year.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for FRAP1 ANTIBODY:

WB: Tested

ELISA, ICC, IHC: Not Tested

TESTING: (secondary reagents and protocols )

Western Blot: Western blot analysis of TOR in L1210 cell lysate with anti-TOR (NT) at (A) 1 and (B) 2 ug/ml. ( anti-FRAP1 )

FRAP1 antibody Western Blot image
FRAP1

FRAP1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for FRAP1 antibody: FRAP1; FRAP; FRAP2; MTOR; RAFT1; FK506-binding protein 12-rapamycin complex-associated protein 1; Rapamycin target protein; RAPT1; Mammalian target of rapamycin; mTOR; FK506 binding protein 12-rapamycin associated protein 1

Function: Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex.

Subunit: Interacts with the FKBP12-rapamycin complex. Binds UBQLN1.

Tissue Specificity: Expressed in numerous tissues, with highest levels in testis.

Similarity: Belongs to the PI3/PI4-kinase family.

Similarity: Contains 1 FAT domain.

Similarity: Contains 1 FATC domain.

Similarity: Contains 7 HEAT repeats.

Similarity: Contains 1 PI3K/PI4K domain.

Summary: The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The CDT6 gene is located in an intron of this gene.

FKBP12-rapamycin complex-associated protein reacts with human, mouse.

OMIM: 601231; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Adipocytokine signaling pathway 04920
KEGG pathway: Glioma 05214
KEGG pathway: Insulin signaling pathway 04910
KEGG pathway: Type II diabetes mellitus 04930
KEGG pathway: mTOR signaling pathway 04150
Reactome Event:Insulin receptor mediated signaling 74752

Products similar to FRAP1 antibody:

IgG

ATR [2B5], IgG

mTOR, IgG

TOR, IgG

ATR [2B5], IgG

mTOR, IgG

Peptide

mTOR(Phospho-Ser2448) Antibody Blocking Peptide, Peptide

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for FRAP1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Fang,P., Hwa,V. and Rosenfeld,R.G., et al.
     Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway
[2] Mendjan,S., Taipale,M., Kind,J., Holz,H., Gebhardt,P., Schelder,M., Vermeulen,M., Buscaino,A., Duncan,K., Mueller,J., Wilm,M.,, et al.
     Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila
[3] Bachmann,R.A., Kim,J.H., Wu,A.L., Park,I.H. and Chen,J., et al.
     A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
[4] Raslova,H., Baccini,V., Loussaief,L., Comba,B., Larghero,J., Debili,N. and Vainchenker,W.
     Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation
[5] Conde,E., Angulo,B., Tang,M., Morente,M., Torres-Lanzas,J., Lopez-Encuentra,A., Lopez-Rios,F. and Sanchez-Cespedes,M.
     Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling
[6] , Brown E.J., Albers M.W., Shin T.B., Ichikawa K., Keith C.T., Lane W.S., Schreiber S.L.
     A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
[7] , Onyango P., Lubyova B., Gardellin P., Kurzbauer R., Weith A.
     Molecular cloning and expression analysis of five novel genes in chromosome 1p36.
[8] , Stover C., Endo Y., Takahashi M., Lynch N., Constantinescu C., Vorup-Jensen T., Thiel S., Friedl H., Hankeln T., Hall R., et al.
     The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
[9] , Chiu M.I., Katz H., Berlin V.
     RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.
[10] , Wu S., Mikhailov A., Kallo-Hosein H., Hara K., Yonezawa K., Avruch J.
     Characterization of ubiquilin 1, an mTOR-interacting protein.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: FRAP1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of FRAP1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about FRAP1 antibody, all related information, articles, resources about FRAP1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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