PRNP antibody, Prion Protein (PrPsc) Antibody, IgG Monoclonal Antibody

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Prion Protein (PrPsc) Antibody, IgG Monoclonal Antibody

Catalog Number: 20-902-170190

Buy PRNP antibody -

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Related Product Names:

- PRNP antibody; PRNP; PRIP; PRP; Prion Protein (PrPsc)
- MONOTOPE Prion Protein (PrPsc); PrP; PrP27-30; PrP33-35C; ASCR; CD230 antigen; Major prion protein

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: PRNP	Gene Name Synonym: PRIP; PRP
Gi #: N/A	NCBI Acc #: NP_000302.1	Swiss Prot Acc #: P04156
Length (aa): N/A	Mol. Weight (Da): 27661	Chrom Location: N/A

Agent: Prion Protein

Specificity: TSE

Ig Class: IgG1

Purified Preparations: MONOTOPE purified preparations consist of >90% pure mouse monoclonal antibody which has been purified from ascites fluid or culture medium by protein A chromatography or sequential differential precipitations. The final preparation is formulated to a protein concentration of 100 ?g/ml in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide. Each vial contains 1.0 ml. This product contains no stabilizing proteins and should be stored at -20°C until ready for use. Avoid repeated freeze-thawing by storing multiple aliquots at -20°C. Custom conjugation of this antibody with HRP, alkaline phosphatase, biotin and fluorescein is available on a minimum order basis

Specificity Note: Reactive with the protease resistant form of PrP in sheep and cattle. Functions in IHC*, WB & ELISA

Conjugation: Purified

Clonality: Monoclonal

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

PRNP ANTIBODY TARGET DESCRIPTION:

Synonym Names for PRNP antibody: PRNP; PRIP; PRP; MONOTOPE Prion Protein (PrPsc); PrP; PrP27-30; PrP33-35C; ASCR; CD230 antigen; Major prion protein

Function: The physiological function of PrP is not known.

Subunit: PrP has a tendency to aggregate yielding polymers called "rods". Interacts with GRB2, PRNPIP and SYN1 (By similarity).

Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus (By similarity).

Ptm: The glycosylation pattern (the amount of mono-, di- and non-glycosylated forms or glycoforms) seems to differ in normal and CJD prion.

Polymorphism: The five tandem octapeptide repeats region is highly unstable. Insertions or deletions of octapeptide repeat units are associated to prion disease.

Disease: PrP is found in high quantity in the brain of humans and animals infected with neurodegenerative diseases known as transmissible spongiform encephalopathies or prion diseases, like: Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI), Gerstmann-Straussler disease (GSD), Huntington disease-like 1 (HDL1) and kuru in humans; scrapie in sheep and goat; bovine spongiform encephalopathy (BSE) in cattle; transmissible mink encephalopathy (TME); chronic wasting disease (CWD) of mule deer and elk; feline spongiform encephalopathy (FSE) in cats and exotic ungulate encephalopathy (EUE) in nyala and greater kudu. The prion diseases illustrate three manifestations of CNS degeneration: (1) infectious (2) sporadic and (3) dominantly inherited forms. TME, CWD, BSE, FSE, EUE are all thought to occur after consumption of prion-infected foodstuffs.

Disease: Defects in PRNP are the cause of Creutzfeldt-Jakob disease (CJD) [MIM:123400]. CJD occurs primarily as a sporadic disorder (1 per million), while 10-15% are familial. Accidental transmission of CJD to humans appears to be iatrogenic (contaminated human growth hormone (HGH), corneal transplantation, electroencephalographic electrode implantation, etc.). Epidemiologic studies have failed to implicate the ingestion of infected annimal meat in the pathogenesis of CJD in human. The triad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration of neurons, (2) severe astrocytic gliosis that often appears to be out of proportion to the degree of nerve cell loss, and (3) amyloid plaque formation. CJD is characterized by progressive dementia and myoclonic seizures, affecting adults in mid-life. Some patients present sleep disorders, abnormalities of high cortical function, cerebellar and corticospinal disturbances. The disease ends in death after a 3-12 months illness.

Disease: Defects in PRNP are the cause of fatal familial insomnia (FFI) [MIM:600072]. FFI is an autosomal dominant disorder and is characterized by neuronal degeneration limited to selected thalamic nuclei and progressive insomnia.

Disease: Defects in PRNP are the cause of Gerstmann-Straussler disease (GSD) [MIM:137440]. GSD is a heterogeneous disorder and was defined as a spinocerebellar ataxia with dementia and plaquelike deposits. GSD incidence is less than 2 per 100 million live births.

Disease: Defects in PRNP are the cause of Huntington disease-like 1 (HDL1) [MIM:603218]. HDL1 is an autosomal dominant, early onset neurodegenerative disorder with prominent psychiatric features.

Disease: Defects in PRNP are the cause of kuru [MIM:245300]. Kuru is transmitted during ritualistic cannibalism, among natives of the New Guinea highlands. Patients exhibit various movement disorders like cerebellar abnormalities, rigidity of the limbs, and clonus. Emotional lability is present, and dementia is conspicuously absent. Death usually occurs from 3 to 12 month after onset.

Disease: Defects in PRNP are the cause of prion disease with protracted course [MIM:606688]; an autosomal dominant presenile dementia with a rapidly progressive and protracted clinical course. The dementia was characterized clinically by frontotemporal features, including early personality changes. Some patients had memory loss, several showed aggressiveness, hyperorality and verbal stereotypy, others had parkinsonian symptoms.

Similarity: Belongs to the prion family.

OMIM: 123400; phenotype. [NCBI / EBI]
137440; phenotype. [NCBI / EBI]
176640; gene. [NCBI / EBI]
245300; phenotype. [NCBI / EBI]
600072; phenotype. [NCBI / EBI]
603218; phenotype. [NCBI / EBI]
606688; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Neurodegenerative Disorders 01510
KEGG pathway: Prion disease 05060

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PRODUCT INTERACTIONS:

Prion Protein (PrPsc) interacts with Amyloid beta A4 protein, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with AMYLOID BETA, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Anti Human Beta Amyloid Protein 1-40 (Anti-betaAP1-40), IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Anti Human Beta Amyloid Protein 17-42 (Anti-betaAP17-42), IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Anti-Human Beta Amyloid Protein Monoclonal Antibody (Anti-Human betaAP), IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Amyloid Precursor Protein [3E9], IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with beta Amyloid [2C8], IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Amyloid Precursor Protein Frameshift Mutant, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Amyloid Precursor Protein, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with beta Amyloid [3G5], IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with beta Amyloid [BAM-10], IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Beta Amyloid N-term. (a.a. 1-8), IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Beta Amyloid a.a. 1-17, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Rabbit anti Beta Amyloid 1-42, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Rabbit anti Beta Amyloid 1-40, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Rabbit A' Amyloid Precursor Pro.(a.a.653-662), IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Rabbit A' Amyloid Precursor Pro.(a.a.737-751), IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Rabbit anti Amyloid, Beta, N-terminal, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Rabbit anti Rat/Mouse Beta Amyloid (3-16), IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Goat A'Amyloid Pre.Pro. Frame (C-term), IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Amyloid Precursor Protein C-term Peptide, Peptide (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Anti-Beta Amyloid, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Amyloid Precursor Protein, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Amyloid Precursor Protein (ready-to-use), IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Amyloid Precursor Protein, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with beta Amyloid [DE2B4], IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Beta Amyloid, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Amyloid Precursor Protein, IgG (GenWay Catalog #: 20-902-170190).

Prion Protein (PrPsc) interacts with Heterogeneous nuclear ribonucleoproteins A2/B1, IgG (GenWay Catalog #: 20-902-170190).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

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Precautions: PRNP antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of PRNP antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about PRNP antibody, all related information, articles, resources about PRNP antibody are being stored on our online database. Let us know if you have questions regarding this product.

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