Alphabetical Listing of Primary Antibodies:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
f
|
0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
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Secondary Antibodies
|
ELISA Kits
TNF-RECEPTOR II (p75/p80) Antibody, Rat IgG2a Monoclonal Antibody
Catalog Number: 20-321-175021
Buy TNFRSF1B antibody -
Size:
0.05 mg ($470.00)
Related Product Names:
- TNFRSF1B antibody; TNFRSF1B; TNFBR; TNFR2; TNF-RECEPTOR II (p75/p80)
- BIOTINYLATED MONOCLONAL ANTIBODY TO MOUSE TNF-RECEPTOR II (p75/p80); Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b antigen; Etanercept; Tumor necrosis factor receptor superfamily member 1B
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
TNFRSF1B
Gene Name Synonym:
TNFBR; TNFR2
Gi #:
N/A
NCBI Acc #:
NP_001057.1
Swiss Prot Acc #:
P20333
Length (aa):
N/A
Mol. Weight (Da):
48291
Chrom Location:
N/A
Clone:
HM102
Applications:
The monoclonal antibody HM102 is an agonistic antibody and can be used for cell culture experiments and for flow cytometry. Furthermore the antibody HM102 is useful for immuno assays. immunoprecipitation and histology on frozen sections. The reactivity of the antibody with soluble TNF-Receptor is not inhibited by high concentrations of mouse TNF-alpha.
Source/Host:
Rat IgG2a
Clonality:
Monoclonal
Crossreactivity:
Mouse
Format:
0.5 ml (100 ug/ml) 0.2 um filtered biotinylated antibody solution in PBS. containing 0.02% sodium azide and 0.1% bovine serum albumin.
Storage:
Product should be stored at 4 degree C
Stability:
Stable for 1 year
Shipping:
Products may be shipped on ice pack or dry ice.
TESTING: (
secondary reagents
and
protocols
)
Not Available
TNFRSF1B ANTIBODY TARGET DESCRIPTION:
Synonym Names for TNFRSF1B antibody:
TNFRSF1B; TNFBR; TNFR2; BIOTINYLATED MONOCLONAL ANTIBODY TO MOUSE TNF-RECEPTOR II (p75/p80); Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b antigen; Etanercept; Tumor necrosis factor receptor superfamily member 1B
The monoclonal antibody HM102 reacts with the extra-cellular part of the mouse TNF-RII and with the soluble receptor. TNF-RII is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. The TNF-RII molecule is shown to be responsible for stimulation of activated T-lymphocytes by TNF-alpha.
Function:
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Subunit:
Binds to TRAF2.
Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:
Isoform 2: Secreted.
Subcellular Location:
Tumor necrosis factor-binding protein 2: Secreted.
Ptm:
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
Ptm:
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
Pharmaceutical:
Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors.
Similarity:
Contains 4 TNFR-Cys repeats.
TNF-RECEPTOR II (p75/p80) reacts with mouse.
OMIM:
191191; gene. [
NCBI
/
EBI
]
Products similar to TNFRSF1B antibody:
IgG
cIAP2, IgG
TNFRSF1B, IgG
LTBR [Carlos-1], IgG
TNF RECEPTOR 2, IgG
CD120b, IgG
Peptide
P75-TNFR, Peptide
sTNFR-II: Human, Recombinant, E Coli, Protein
TNFR Human, Protein
sTNFR-II: Human, Recombinant, E Coli, Protein
sTNFR-II: Human, Recombinant, E Coli, Protein
PRODUCT INTERACTIONS:
TNF-RECEPTOR II (p75/p80)
interacts
with
CD120b. TNF-RII (p75/p80), IgG
(GenWay Catalog #: 20-321-175021)
.
TNF-RECEPTOR II (p75/p80)
interacts
with
CD120b. TNF-RII (p75/p80), IgG
(GenWay Catalog #: 20-321-175021)
.
TNF-RECEPTOR II (p75/p80)
interacts
with
CD120b. TNF-RII (p75/p80), IgG
(GenWay Catalog #: 20-321-175021)
.
TNF-RECEPTOR II (p75/p80)
interacts
with
CD120b. TNF-RII (p75/p80), IgG
(GenWay Catalog #: 20-321-175021)
.
TNF-RECEPTOR II (p75/p80)
interacts
with
TRAF2 [33A1293], IgG
(GenWay Catalog #: 20-321-175021)
.
TNF-RECEPTOR II (p75/p80)
interacts
with
Rabbit anti TRAF-2, IgG
(GenWay Catalog #: 20-321-175021)
.
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
TNFRSF1B antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of TNFRSF1B antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about TNFRSF1B antibody, all related information, articles, resources about TNFRSF1B antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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