Jam3 antibody, JUNCTIONAL ADHESION MOLECULE-C (JAM-C) Antibody, Rat IgG2a Monoclonal Antibody

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JUNCTIONAL ADHESION MOLECULE-C (JAM-C) Antibody, Rat IgG2a Monoclonal Antibody

Catalog Number: 20-321-175059

Buy Jam3 antibody -

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Related Product Names:

- Jam3 antibody; Jam3; JUNCTIONAL ADHESION MOLECULE-C (JAM-C)
- MONOCLONAL ANTIBODY TO MOUSE JUNCTIONAL ADHESION MOLECULE-C (JAM-C); JAM-C; Junctional adhesion molecule 3; JAM-3; JAM-2; Junction adhesion molecule 3 [Mus musculus]; Junctional adhesion molecule C

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Jam3	Gene Name Synonym: N/A
Gi #: 12963613	NCBI Acc #: NP_075766.1	Swiss Prot Acc #: Q9D8B7
Length (aa): 310	Mol. Weight (Da): 34838	Chrom Location: N/A

Clone: CRAM-19 H36

Applications: Monoclonal antibody CRAM-19 H36 can be used for immuno precipiation. immuno assays as detector antibody. immunohistology on frozen sections and flow cytometry. Antibody CRAM-19 H36 cannot be used for Western blot and immunohistology on paraffin sections.

Source/Host: Rat IgG2a

Clonality: Monoclonal

Crossreactivity: Mouse

Format: 1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS. containing 0.02% sodium azide and 0.1% bovine serum albumin.

Storage: Product should be stored at 4 degree C

Stability: Stable for 1 year

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

JAM3 ANTIBODY TARGET DESCRIPTION:

Synonym Names for Jam3 antibody: Jam3; MONOCLONAL ANTIBODY TO MOUSE JUNCTIONAL ADHESION MOLECULE-C (JAM-C); JAM-C; Junctional adhesion molecule 3; JAM-3; JAM-2; Junction adhesion molecule 3 [Mus musculus]; Junctional adhesion molecule C

Junctional adhesion molecule-C (JAM-C) also known as JAM-2 is a 45 kD cell adhesion molecule (CAM). JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1. 7H6 antigen. cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium. in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs. lymphoendothelial cells and endothelial cells in kidney. Monoclonal antibody CRAM-19 H36 also reacts with human JAM-C. In humans. JAM-C expression is not restricted to endothelial cells. but is also expressed on human lymphocytes.

Function: May participate in cell-cell adhesion distinct from tight junctions.

Subunit: Interacts with JAM2 (By similarity).

Subcellular Location: Membrane; Single-pass type I membrane protein (Potential).

Tissue Specificity: Endothelial cells.

Similarity: Belongs to the immunoglobulin superfamily.

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

JUNCTIONAL ADHESION MOLECULE-C (JAM-C) reacts with mouse.

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for JAM3 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Imhof,B.A., Zimmerli,C., Gliki,G., Ducrest-Gay,D., Juillard,P., Hammel,P., Adams,R. and Aurrand-Lions,M.
     Pulmonary dysfunction and impaired granulocyte homeostasis result in poor survival of Jam-C-deficient mice
[2] Sircar,M., Bradfield,P.F., Aurrand-Lions,M., Fish,R.J., Alcaide,P., Yang,L., Newton,G., Lamont,D., Sehrawat,S., Mayadas,T., Liang,T.W.,, et al.
     Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent
[3] Fuse,C., Ishida,Y., Hikita,T., Asai,T. and Oku,N., et al.
     Junctional adhesion molecule-C promotes metastatic potential of HT1080 human fibrosarcoma
[4] Mandicourt,G., Iden,S., Ebnet,K., Aurrand-Lions,M. and Imhof,B.A., et al.
     JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration
[5] Sakaguchi,T., Nishimoto,M., Miyagi,S., Iwama,A., Morita,Y., Iwamori,N., Nakauchi,H., Kiyonari,H., Muramatsu,M. and Okuda,A.
     Putative 'stemness' gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells
[6] Aurrand-Lions M.A., Duncan L., Du Pasquier L., Imhof B.A.
     Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family?
[7] Aurrand-Lions M.A., Duncan L., Ballestrem C., Imhof B.A.
     JAM-2, a novel immunoglobulin superfamily molecule, expressed by endothelial and lymphatic cells.
[8] Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., et al.
     The transcriptional landscape of the mammalian genome.
[9] Lubec G., Kang S.U.
     Submitted (APR-2007) to Swiss-Prot.
[10] Aurrand-Lions M.A., Johnson-Leger C., Wong C., Du Pasquier L., Imhof B.A.
     Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members.

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Precautions: Jam3 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Jam3 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Jam3 antibody, all related information, articles, resources about Jam3 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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