TLR9 antibody, TOLL-LIKE RECEPTOR 9 (TLR9. CD289) Antibody, Mouse IgG2a Monoclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

TOLL-LIKE RECEPTOR 9 (TLR9. CD289) Antibody, Mouse IgG2a Monoclonal Antibody

Catalog Number: 20-321-175167

Buy TLR9 antibody -

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Related Product Names:

- TLR9 antibody; TLR9; TOLL-LIKE RECEPTOR 9 (TLR9. CD289)
- BIOTINYLATED MONOCLONAL ANTIBODY TO HUMAN TOLL-LIKE RECEPTOR 9 (TLR9. CD289); CD289 antigen; Toll-like receptor 9

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: TLR9	Gene Name Synonym: N/A
Gi #: 11761321	NCBI Acc #: BAB19259.1	Swiss Prot Acc #: Q9NR96
Length (aa): 1032	Mol. Weight (Da): 115860	Chrom Location: N/A

Clone: 5G5

Applications: The monoclonal antibody 5G5 can be used for flow cytometry. Western blotting and immuno assays as detection antibody. Furthermore the monoclonal antibody 5G5 is useful for immunohistology on frozen sections. The monoclonal antibody 5G5 stains RAW macrophages and TLR9 transfected HEK293 cells.

Source/Host: Mouse IgG2a

Clonality: Monoclonal

Crossreactivity: Human

Format: 0.5 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS. containing 0.02% sodium azide and 0.1% bovine serum albumin.

Storage: Product should be stored at 4 degree C

Stability: Stable for 1 year

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

TLR9 ANTIBODY TARGET DESCRIPTION:

Synonym Names for TLR9 antibody: TLR9; BIOTINYLATED MONOCLONAL ANTIBODY TO HUMAN TOLL-LIKE RECEPTOR 9 (TLR9. CD289); CD289 antigen; Toll-like receptor 9

Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defence to many pathogens. In Drosophila toll is required for the anti-fungal response. while the related 18-wheeler is involved in antibacterial defences. In mammals. TLR identified as type I transmembrane signalling receptors with pattern recognition capabilities. have been implicated in the innate host defence to pathogens. As investigated so far all functional characterized TLR signal via the TLR/IL-1 receptor (IL-1R) pathway where recruitment of MyD88 seems to be essential. In contrast to cell-wall components. bacterial DNA is probably invisible for immune cells until DNA is liberated during processes taking place in the endosomal/lysosomal compartment where intracellular TLR9 (CD289) recruits MyD88 to initiate signal transduction. Unmethylated CpG-dinucleotide-containing sequences are found much more frequently in bacterial genomes than in vertebrates genomes. whereas the frequency of CpG dinucleotides are suppressed and usually methylated. The regions adjacent to the CpG dinucleotides also affect the immunostimulatory activity. The optimal sequence differs significantly between mammalian species. Methylated CpG dinucleotides lack immunostimulatory activities. Cellular activation in response to bacterial DNA and synthetic dinucleotides containing unmethylated CpG-dinucleotides is mediated by TLR9. The antibody is cross reactive with mouse TLR9.

Function: Participates in the innate immune response to microbial agents. Detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Subunit: Binds MyD88 via their respective TIR domains (By similarity).

Subcellular Location: Membrane; Single-pass type I membrane protein (By similarity).

Tissue Specificity: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Similarity: Belongs to the Toll-like receptor family.

Similarity: Contains 26 LRR (leucine-rich) repeats.

Similarity: Contains 1 TIR domain.

TOLL-LIKE RECEPTOR 9 (TLR9. CD289) reacts with human.

OMIM: 605474; gene. [NCBI / EBI]

Products similar to TLR9 antibody:

IgG

TLR9, IgG

TLR9 [26C593], IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for TLR9 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Hemmi,H., Takeuchi,O., Kawai,T., Kaisho,T., Sato,S., Sanjo,H., Matsumoto,M., Hoshino,K., Wagner,H., Takeda,K. and Akira,S.
     A Toll-like receptor recognizes bacterial DNA
[2] Akira,S. and Hemmi,H., et al.
     Direct Submission
[3] Du X., Poltorak A., Wei Y., Beutler B.
     Three novel mammalian Toll-like receptors: gene structure, expression, and evolution.
[4] Chuang T.-H., Ulevitch R.J.
     Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9.
[5] Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., et al.
     A Toll-like receptor recognizes bacterial DNA.
[6] Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., et al.
     The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
[7] Takeshita F., Leifer C.A., Gursel I., Ishii K.J., Takeshita S., Gursel M., Klinman D.M.
     Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: TLR9 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of TLR9 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about TLR9 antibody, all related information, articles, resources about TLR9 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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