F11R antibody, JUNCTIONAL ADHESION MOLECULE-A (JAM-A) Antibody, Mouse IgG1 Monoclonal Antibody

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JUNCTIONAL ADHESION MOLECULE-A (JAM-A) Antibody, Mouse IgG1 Monoclonal Antibody

Catalog Number: 20-321-175174

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Related Product Names:

- F11R antibody; F11R; JAM1; JCAM; JUNCTIONAL ADHESION MOLECULE-A (JAM-A)
- MONOCLONAL ANTIBODY TO HUMAN JUNCTIONAL ADHESION MOLECULE-A (JAM-A); JAM-A; Junctional adhesion molecule 1; JAM-1; Platelet adhesion molecule 1; PAM-1; Platelet F11 receptor; CD321 antigen; Junctional adhesion molecule A

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: F11R	Gene Name Synonym: JAM1; JCAM
Gi #: N/A	NCBI Acc #: NP_058642.1	Swiss Prot Acc #: Q9Y624
Length (aa): N/A	Mol. Weight (Da): 32583	Chrom Location: N/A

Clone: M.Ab.F11

Applications: The monoclonal antibody M.Ab.F11 can be used for flow cytometry. Western blotting and immuno precipitation. Furthermore the monoclonal antibody M.Ab.F11 is useful for functional studies. The antibody directly stimulates the aggregation and granule secretion of human platelets.

Source/Host: Mouse IgG1

Clonality: Monoclonal

Crossreactivity: Human

Format: 1 ml (100 ug/ml) 0.2 um filtered sterile antibody solution in PBS. containing 0.1% bovine serum albumin.

Storage: Product should be stored at 4 degree C

Stability: Stable for 1 year

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

F11R ANTIBODY TARGET DESCRIPTION:

Synonym Names for F11R antibody: F11R; JAM1; JCAM; MONOCLONAL ANTIBODY TO HUMAN JUNCTIONAL ADHESION MOLECULE-A (JAM-A); JAM-A; Junctional adhesion molecule 1; JAM-1; Platelet adhesion molecule 1; PAM-1; Platelet F11 receptor; CD321 antigen; Junctional adhesion molecule A

The monoclonal antibody M.Ab.F11 recognizes junctional adhesion molecule-A (JAM-A) also known as the human platelet F11-Receptor (F11R) and JAM-1 is a cell adhesion molecule (CAM). JAM-A is a member of the immunoglobulin superfamily found on the surface of human platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-A belongs together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1. 7H6 antigen. cingulin and occludin. JAM-A plays a role in platelet aggregation. secretion. adhesion. spreading. In the platelet F11R/JAM-A is a membrane protein involved in 2 distinct processes initiated on the platelet surface. Antibody-induced platelet aggregation and secretion both dependent on FcgammaRII and GPIIb/IIIa integrin. a process that may be involved in pathophysiological processes associated with certain thrombocytopenias. Antibody mediated platelet adhesion independent from FcgammaRII or fibrinogen receptor and that appears to play a role in physiological processes associated with platelet adhesion and aggregation. A physiological role for the F11R/JAM-A protein was demonstrated by its phosphorylation after the stimulation of platelets by thrombin and collagen. A pathophysiological role for the F11R/JAM-A was revealed by demonstrating the presence of F11R/JAM-A antibodies in patients with thrombocytopenia. Adhesion of platelets through the F11R resulted in events characteristic of the action of cell adhesion molecules (CAMs). Recent data suggests a role for F11R/JAM-A in the adhesion of platelets to cytokine-inflamed endothelial cells and thus in thrombosis and atherosclerosis induced in non-denuded blood vessels by inflammatory processes.

Function: Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.

Subunit: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein (By similarity).

Subcellular Location: Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.

Ptm: N-glycosylated.

Similarity: Belongs to the immunoglobulin superfamily.

Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains.

JUNCTIONAL ADHESION MOLECULE-A (JAM-A) reacts with human.

OMIM: 605721; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Cell adhesion molecules (CAMs) 04514
KEGG pathway: Epithelial cell signaling in Helicobacter pylori infection 05120
KEGG pathway: Leukocyte transendothelial migration 04670
KEGG pathway: Tight junction 04530
Reactome Event:Hemostasis 109582
Reactome Event:Signaling in Immune system 168256

Products similar to F11R antibody:

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JUNCTIONAL ADHESION MOLECULE-A (JAM-A), IgG

CD321, IgG

JUNCTIONAL ADHESION MOLECULE-A (JAM-A), IgG

CD321, IgG

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Precautions: F11R antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of F11R antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about F11R antibody, all related information, articles, resources about F11R antibody are being stored on our online database. Let us know if you have questions regarding this product.

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