S100A8 antibody, S100A8/A9 (MRP-8/MRP-14). CALPROTECTIN Antibody, Mouse IgG1 Monoclonal Antibody

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S100A8/A9 (MRP-8/MRP-14). CALPROTECTIN Antibody, Mouse IgG1 Monoclonal Antibody

Catalog Number: 20-321-175204

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Related Product Names:

- S100A8 antibody; S100A8; CAGA; CFAG; MRP8; S100A8/A9 (MRP-8/MRP-14). CALPROTECTIN
- MONOCLONAL ANTIBODY TO HUMAN S100A8/A9 (MRP-8/MRP-14). CALPROTECTIN; S100 calcium-binding protein A8; Calgranulin-A; Migration inhibitory factor-related protein 8; MRP-8; Cystic fibrosis antigen; CFAG; P8; Leukocyte L1 complex light chain; Calprotectin L1; Protein S100-A8

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: S100A8	Gene Name Synonym: CAGA; CFAG; MRP8
Gi #: N/A	NCBI Acc #: NP_002955.2	Swiss Prot Acc #: P05109
Length (aa): N/A	Mol. Weight (Da): 10835	Chrom Location: N/A

Clone: 270000000000

Applications: The monoclonal antibody 27E10 can be used for immuno assays both as coating and as detector. Western blotting. immuno precipitation and flow cytometry. Furthermore the antibody 27E10 is useful for immunohistology on frozen and paraffin sections.

Source/Host: Mouse IgG1

Clonality: Monoclonal

Crossreactivity: Human

Format: 1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS. containing 0.02% sodium azide and 0.1% bovine serum albumin.

Storage: Product should be stored at 4 degree C

Stability: Stable for 1 year

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

S100A8 ANTIBODY TARGET DESCRIPTION:

Synonym Names for S100A8 antibody: S100A8; CAGA; CFAG; MRP8; MONOCLONAL ANTIBODY TO HUMAN S100A8/A9 (MRP-8/MRP-14). CALPROTECTIN; S100 calcium-binding protein A8; Calgranulin-A; Migration inhibitory factor-related protein 8; MRP-8; Cystic fibrosis antigen; CFAG; P8; Leukocyte L1 complex light chain; Calprotectin L1; Protein S100-A8

The monoclonal antibody 27E10 is a unique antibody recognising an epitope on the S100A8/A9 heterocomplex that is not exposed on the individual subunits S100A8 (MRP8) or S100A9 (MRP14). The calcium.binding. migration inhibitory factor-related proteins. MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex. also called MRP-8/MRP-14 complex or calprotectin. comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes. macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly. neutrophils only intracellularly. The S100A8/A9 complex has antibacterial. antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity. Granulocytes terminate their existence after transmigration through the intestinal wall. Therefore calprotectin is also detectable in faeces. The monoclonal antibody 27E10 can be used for early detection of inflammatory macrophages. for the characterisation of tumorous tissues and the monitoring of peripheral blood cell cultures. The antibody 27E10 does not react with lymphocytes or platelets. 27E10 shows cross-reaction with a subpopulation of macrophages of rhesus monkey.

Function: Expressed by macrophages in chronic inflammations. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermediate filaments in monocytes and epithelial cells.

Subunit: Homodimer.

Miscellaneous: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.

Similarity: Belongs to the S-100 family.

Similarity: Contains 2 EF-hand domains.

S100A8/A9 (MRP-8/MRP-14). CALPROTECTIN reacts with human.

OMIM: 123885; gene. [NCBI / EBI]

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Precautions: S100A8 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of S100A8 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about S100A8 antibody, all related information, articles, resources about S100A8 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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