MPO antibody, MYELOPEROXIDASE (MPO) Antibody, Mouse IgG1 Monoclonal Antibody

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MYELOPEROXIDASE (MPO) Antibody, Mouse IgG1 Monoclonal Antibody

Catalog Number: 20-321-175210

Buy MPO antibody -

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Related Product Names:

- MPO antibody; MPO; MYELOPEROXIDASE (MPO)
- BIOTINYLATED MONOCLONAL ANTIBODY TO HUMAN MYELOPEROXIDASE (MPO); EC 1.11.1.7; MPO; Myeloperoxidase

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: MPO	Gene Name Synonym: N/A
Gi #: 4557759	NCBI Acc #: NP_000241.1	Swiss Prot Acc #: P05164
Length (aa): 745	Mol. Weight (Da): 83869	Chrom Location: N/A

Clone: 266-6K1

Applications: The monoclonal antibody 266-6K1 can be used for immuno assays. Western blotting and immunohistology on frozen sections.

Source/Host: Mouse IgG1

Clonality: Monoclonal

Crossreactivity: Human

Format: 0.5 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS. containing 0.02% sodium azide and 0.1% bovine serum albumin.

Storage: Product should be stored at 4 degree C

Stability: Stable for 1 year

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

MPO ANTIBODY TARGET DESCRIPTION:

Synonym Names for MPO antibody: MPO; BIOTINYLATED MONOCLONAL ANTIBODY TO HUMAN MYELOPEROXIDASE (MPO); EC 1.11.1.7; MPO; Myeloperoxidase

The monoclonal antibody 266-6K1 reacts with Myeloperoxidase (MPO). a glycoprotein with an alpha2beta2 heteromultimer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl). a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis. lung cancer. Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegeners disease. Since the discovery of MPO deficiency. initially regarded as rare and restricted to patients suffering from severe infections. MPO has attracted more clinical attention. In experimental studies antibodies to MPO can be used for various purposes ranging from flow cytometric analysis to detection of polymorphonuclear neutrophils in tissue sections.

Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Catalytic Activity: Donor + H2O2 = oxidized donor + 2 H2O.

Catalytic Activity: Cl- + H2O2 = HOCl + 2 H2O.

Cofactor: Binds 1 calcium ion per heterodimer.

Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.

Subunit: Tetramer of two light chains and two heavy chains.

Subcellular Location: Lysosome.

Disease: Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.

Similarity: Belongs to the peroxidase family. XPO subfamily.

Summary: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils.

MYELOPEROXIDASE (MPO) reacts with human.

OMIM: 254600; phenotype. [NCBI / EBI]
606989; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Coumarine and phenylpropanoid biosynthesis 00940
KEGG pathway: Methane metabolism 00680
KEGG pathway: Phenylalanine metabolism 00360

Products similar to MPO antibody:

IgG

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MPO [MPO-7], IgG

MPO [2C7] (FITC), IgG

Dab1 phospho S491, IgG

MPO [4A4], IgG

Peptide

TP-5, Peptide

Thymopentin, Peptide

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for MPO ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Zhang,J., Zhu,F.Y., Pu,Y.P., Yin,L.H., Luo,J., Wang,W.P. and Zhou,G.H.
     Analysis of multiple single nucleotide polymorphisms (SNPs) of myeloperoxidase (MPO) to screen for genetic markers associated with acute leukemia in Chinese Han population
[2] Kettle,A.J., Anderson,R.F., Hampton,M.B. and Winterbourn,C.C., et al.
     Reactions of superoxide with myeloperoxidase
[3] Taioli,E., Benhamou,S., Bouchardy,C., Cascorbi,I., Cajas-Salazar,N., Dally,H., Fong,K.M., Larsen,J.E., Le Marchand,L.,, et al.
     Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis
[4] Proteasa,G., Tahboub,Y.R., Galijasevic,S., Raushel,F.M. and Abu-Soud,H.M.
     Kinetic evidence supports the existence of two halide binding sites that have a distinct impact on the heme iron microenvironment in myeloperoxidase
[5] Kaneski,C.R., Moore,D.F., Ries,M., Zirzow,G.C. and Schiffmann,R., et al.
     Myeloperoxidase predicts risk of vasculopathic events in hemizgygous males with Fabry disease
[6] Morishita K., Kubota N., Asano S., Kaziro Y., Nagata S.
     Molecular cloning and characterization of cDNA for human myeloperoxidase.
[7] Morishita K., Tsuchiya M., Asano S., Kaziro Y., Nagata S.
     Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor.
[8] Johnson K.R., Nauseef W.M., Care A., Wheelock M.J., Shane S., Hudson S., Koeffler H.P., Selsted M., Miller C., Rovera G., et al.
     Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species.
[9] Johnson K.R., Gemperlein I., Hudson S., Shane S., Rovera G.
     Complete nucleotide sequence of the human myeloperoxidase gene.
[10] Seto P., Hirayu H., Magnusson R.P., Gestautas J., Portmann L., Degroot L.J., Rapoport B.
     Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase.

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Precautions: MPO antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of MPO antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about MPO antibody, all related information, articles, resources about MPO antibody are being stored on our online database. Let us know if you have questions regarding this product.

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