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| LACTOFERRIN (LF) Antibody, Mouse IgG1 Monoclonal Antibody |
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| Catalog Number: 20-321-175214 |
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| Related Product Names:
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LTF antibody; LTF; LF; LACTOFERRIN (LF)
- MONOCLONAL ANTIBODY TO HUMAN LACTOFERRIN (LF); EC 3.4.21.-; Lactoferrin; Talalactoferrin alfa; Lactoferrin; Lactotransferrin |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: LTF |
Gene Name Synonym: LF |
Gi #:
263312 |
NCBI Acc #:
AAB24877.1 |
Swiss Prot Acc #:
P02788 |
Length (aa): 15 |
Mol. Weight (Da): 78182 |
Chrom Location: N/A |
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 Clone: 265-1K1
Applications: The monoclonal antibody 265-1K1 can be used for immunohistology on frozen sections and Western blotting. Furthermore the monoclonal antibody 265-1K1 is useful for immuno assays.
Source/Host: Mouse IgG1
Clonality: Monoclonal
Crossreactivity: Human
Format: 1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS. containing 0.02% sodium azide and 0.1% bovine serum albumin.
Storage: Product should be stored at 4 degree C
Stability: Stable for 1 year
Shipping: Products may be shipped on ice pack or dry ice. |
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| LTF ANTIBODY TARGET DESCRIPTION: |
Synonym Names for LTF antibody: LTF; LF; MONOCLONAL ANTIBODY TO HUMAN LACTOFERRIN (LF); EC 3.4.21.-; Lactoferrin; Talalactoferrin alfa; Lactoferrin; Lactotransferrin
The monoclonal antibody 265-1K1 reacts with human lactoferrin (LF). an 80 kDa glycoprotein. Lactoferrin was first isolated from human milk and plays an important part in the immune system and helps to fight infections. Lactoferrin promotes the health of the gastro-intestinal system by improving the intestinal microbial balance. In addition. LF can be found in epithelia and most body fluids and secretions. Lactoferrin is secreted in plasma by neutrophils. Its plasma concentration also represents a positive relation to the total pool of neutrophils and the rate of neutrophil turnover. In inflammation lactoferrin is released from secondary granules of neutrophilic leukocytes into the extracellular medium. Therefore the extracellular lactoferrin concentration can be used as an index for neutrophil activation. Lactoferrin strongly binds to iron and this iron binding property is considered to be an important antimicrobial. Human lactoferrin binds to bacterial products through its highly positively charged N-terminus. it kills various bacteria. most probably by inducing intracellular changes in these bacteria without affecting the membrane permeability. Cleavage by pepsin of lactoferrin leads to the release of lactoferricin H. This 47 amino acid peptide has more antimicrobial activity than its precursor and it can inhibit the classical but not the alternative complement pathway. Lactoferrin also plays a role in signal transduction. immunomodulation and has antiadhesive. anticancer. antiviral activity.
Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
Function: Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration.
Function: Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.
Function: The lactotransferrin peptidase S60 domain 1 functions as a serine protease that cuts arginine rich regions. This function contributes to the antimicrobial activity.
Catalytic Activity: Preferential at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin.
Subunit: Monomer.
Subcellular Location: Secreted.
Miscellaneous: The second peptidase S60 domain does not have protease function as the catalytic residues are missing.
Similarity: Belongs to the transferrin family.
Similarity: Contains 2 peptidase S60 domains [view classification].
LACTOFERRIN (LF) reacts with human.
OMIM: 150210; gene. [NCBI / EBI]
245480; phenotype. [NCBI / EBI]
Products similar to LTF antibody:
IgG
 CD15 Granulocytes, IgG
CD15 [MY-1], IgG
HTLF, IgG
RFLAT / KLF13, IgG
Kruppel-like factor 11, mRNA (cDNA clone MGC:104116IMAGE:30915570),, IgG
Native_Protein
LACTOFERRIN, Native_Protein
LF Human, Native_Protein
Human Lactoferrin, Apo Form, Native_Protein
LFA-3 Human, Protein
Translin, Protein
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for LTF ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
[1] Teng,C.T., Liu,Y., Yang,N., Walmer,D. and Panella,T., et al.
Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse
[2] Rey M.W., Woloshuk S.L., de Boer H.A., Pieper F.R.
Complete nucleotide sequence of human mammary gland lactoferrin.
[3] Cho Y.Y.
Thesis (1994), Genetic Engineering Research Institute, South Korea.
[4] Conneely O.M.
Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases.
[5] Liang Q., Jimenez-Flores R., Richardson T.
Molecular cloning and sequence analysis of human lactoferrin.
[6] Wei X., Han J., Rado T.A.
Human neutrophil lactoferrin coding and 5' flanking region DNA sequences.
[7] Cheng H., Chen X.Z., Huan L.D.
cDNA cloning and sequence analysis of human lactoferrin.
[8] Kaplan J.B., Fine D.H.
Characterization of an amino acid polymorphism in the antibacterial domain of human lactoferrin.
[9] Shi Y.-Q., Zhang Y., Zheng Y.-M.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
[10] Baskar Singh S., Saravanan K., Paramasivam M., Srinivasan A., Singh T.P.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: LTF antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of LTF antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about LTF antibody, all related information, articles, resources about LTF antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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