Asgr1 antibody, ASIALOGLYCOPROTEIN RECEPTOR (ASGPR) Antibody, Mouse IgG1 Monoclonal Antibody

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ASIALOGLYCOPROTEIN RECEPTOR (ASGPR) Antibody, Mouse IgG1 Monoclonal Antibody

Catalog Number: 20-321-175239

Buy Asgr1 antibody -

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Related Product Names:

- Asgr1 antibody; Asgr1; Asgr-1; ASIALOGLYCOPROTEIN RECEPTOR (ASGPR)
- MONOCLONAL ANTIBODY TO RAT ASIALOGLYCOPROTEIN RECEPTOR (ASGPR); ASGPR 1; ASGP-R 1; Hepatic lectin 1; MHL-1; Asialoglycoprotein receptor [Mus musculus]; Asialoglycoprotein receptor 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Asgr1	Gene Name Synonym: Asgr-1
Gi #: 488076	NCBI Acc #: AAB60441.1	Swiss Prot Acc #: P34927
Length (aa): 284	Mol. Weight (Da): 32604	Chrom Location: N/A

Clone: 8D7

Precautions: For research use only. Not for use in or on humans or animals for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. GenWay is not responsible for any patent infringements that might result with the use of or derivation of this product

Applications: The monoclonal antibody 8D7 can be used for flow cytometry. Western blotting (non-reducing conditions) and immunohistology on frozen sections. Furthermore the monoclonal antibody 8D7 is useful as detector in immuno assays.

Use: For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10

Source/Host: Mouse IgG1

Clonality: Monoclonal

Crossreactivity: Rat

Format: 0.2 um filtered antibody solution in PBS. containing 0.02% sodium azide and 0.1% bovine serum albumin.

Storage: Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year

Stability: Stable for 1 year

Shipping: Products may be shipped on ice pack or dry ice.

TESTING: (secondary reagents and protocols )

Not Available

ASGR1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for Asgr1 antibody: Asgr1; Asgr-1; MONOCLONAL ANTIBODY TO RAT ASIALOGLYCOPROTEIN RECEPTOR (ASGPR); ASGPR 1; ASGP-R 1; Hepatic lectin 1; MHL-1; Asialoglycoprotein receptor [Mus musculus]; Asialoglycoprotein receptor 1

The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) which mediates binding. internalisation and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner. i.e. it is present on the sinusoidal and lateral plasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediates the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed. The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1. RHL-2 and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope on RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.

Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Subunit: Interacts with LASS2 (By similarity).

Subcellular Location: Membrane; Single-pass type II membrane protein.

Tissue Specificity: Expressed exclusively in hepatic parenchymal cells.

Ptm: Phosphorylated on a cytoplasmic Ser residue (By similarity).

Miscellaneous: Calcium is required for ligand binding.

Similarity: Contains 1 C-type lectin domain.

ASIALOGLYCOPROTEIN RECEPTOR (ASGPR) reacts with rat.

Products similar to Asgr1 antibody:

IgG

ASGR1 (asialoglycoprotein receptor 1), IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for ASGR1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Monroe,R.S. and Huber,B.E., et al.
     The major form of the murine asialoglycoprotein receptor: cDNA sequence and expression in liver, testis and epididymis
[2] Takezawa,R., Shinzawa,K., Watanabe,Y. and Akaike,T., et al.
     Determination of mouse major asialoglycoprotein receptor cDNA sequence
[3] Huber,B.E., et al.
     Direct Submission
[4] Takezawa R., Shinzawa K., Watanabe Y., Akaike T.
     Determination of mouse major asialoglycoprotein receptor cDNA sequence.
[5] Monroe R.S., Huber B.E.
     The major form of the murine asialoglycoprotein receptor: cDNA sequence and expression in liver, testis and epididymis.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: Asgr1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Asgr1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Asgr1 antibody, all related information, articles, resources about Asgr1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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