HNRNP C1/C2 antibody, HNRNP C1/C2 [4F4] Antibody, Mouse Monoclonal Antibody

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HNRNP C1/C2 [4F4] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-190171

Buy HNRNP C1/C2 antibody -

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Related Product Names:

- HNRNP C1/C2 antibody; HNRNP C1/C2; C1 C2 Heterogeneous nuclear ribonucleoproteins C1/C2 HNRNP hnRNP C1 / hnRNP C2 hnRNPC Nuclear ribonucleoprotein particle C1 prot; HNRNP C1/C2 [4F4]
- Mouse monoclonal [4F4] to hnRNP C1 + C2; Heterogeneous nuclear ribonucleoproteins C1/C2

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: HNRNP C1/C2	Gene Name Synonym: C1 C2 Heterogeneous nuclear ribonucleoproteins C1/C2 HNRNP hnRNP C1 / hnRNP C2 hnRNPC Nuclear ribonucleoprotein particle C1 prot
Gi #: N/A	NCBI Acc #: NP_001070910.1	Swiss Prot Acc #: P07910
Length (aa): N/A	Mol. Weight (Da): 33670	Chrom Location: N/A

Clone: 4F4

Isotype: IgG1

Immunogen: RNP?s eluted from oligo (dT) cellulose column

Target: HNRNP C1/C2

Concentration: 2.1 mg/ml

Purification Note: Protein A purified from tissue culture supernatant.

Storage Buffer: Preservative: 0.1% Sodium Azide; Constituents: PBS

Application Note: ELISA: Use at an assay dependent dilution. IF: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Detects bands of approximately 41 kDa (C1) and 43 kDa (C2). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Myeloma: Sp2/0

Source/Host: Mouse

Purity/Purification: Protein A purified

Clonality: Monoclonal

Crossreactivity: Cross-reacts with Human, Chicken, Hamster and Monkey. Not yet tested in other species.

Storage: Aliquot and store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for HNRNP C1/C2 ANTIBODY:

ELISA, IF, IP, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

HNRNP C1/C2 ANTIBODY TARGET DESCRIPTION:

Synonym Names for HNRNP C1/C2 antibody: HNRNP C1/C2; C1 C2 Heterogeneous nuclear ribonucleoproteins C1/C2 HNRNP hnRNP C1 / hnRNP C2 hnRNPC Nuclear ribonucleoprotein particle C1 prot; Mouse monoclonal [4F4] to hnRNP C1 + C2; Heterogeneous nuclear ribonucleoproteins C1/C2

The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP C1 and C2 are encoded by one gene; the two alternatively spliced transcript variants have been described.

Function: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.

Subunit: Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8.

Subcellular Location: Nucleus. Note=Component of ribonucleosomes.

Ptm: Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.

Ptm: Sumoylated. Sumoylation reduces affinity for mRNA.

Similarity: Belongs to the RRM HNRPC family. RALY subfamily.

Similarity: Contains 1 RRM (RNA recognition motif) domain.

HNRNP C1/C2 [4F4] reacts with cross-reacts with human, chicken, hamster and monkey. not yet tested in other species..

OMIM: 164020; gene. [NCBI / EBI]

Pathways:
Reactome Event:Gene Expression 74160
Reactome Event:Influenza Infection 168254
Reactome Event:mRNA Processing 75071

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Precautions: HNRNP C1/C2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of HNRNP C1/C2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about HNRNP C1/C2 antibody, all related information, articles, resources about HNRNP C1/C2 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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