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| Oncostatin M [17001.31] Antibody, Mouse Monoclonal Antibody |
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| Catalog Number: 20-272-190299 |
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| Related Product Names:
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Oncostatin M antibody; Oncostatin M; Oncostatin M [17001.31]
- Mouse monoclonal [17001.31] to Oncostatin M; Oncostatin-M |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: Oncostatin M |
Gene Name Synonym: N/A |
Gi #:
N/A |
NCBI Acc #:
NP_065391.1 |
Swiss Prot Acc #:
P13725 |
Length (aa): N/A |
Mol. Weight (Da): 28484 |
Chrom Location: N/A |
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 Clone: 17001.31
Isotype: IgG2a
Immunogen: Recombinant full length protein (Human) expressed in E. coli.
Antigen Species: Human
Specificity: GTX10842 shows < 10% cross-reactivity with recombinant human LIF, but does not cross-react with recombinant mouse OSM and recombinant human IL6.
Positive Control: Tested with human TF-1 cell line.
Target: Oncostatin M
Localization: Secreted
Concentration: 0.5 mg/ml
Storage Buffer: Constituents: PBS
Application Note: ELISA: Use at a concentration of 0.5-1 µg/ml. Neut: ND50 = 0.1 - 5 µg/mlWB: Use at a concentration of 1-2 µg/ml. Predicted molecular weight: 22 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Cellular Localization: Secreted
Source/Host: Mouse
Purity/Purification: Protein A purified
Clonality: Monoclonal
Crossreactivity: Cross-reacts with Human. Does not cross-react with Mouse. Not yet tested in other species.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for ONCOSTATIN M ANTIBODY: |
| ELISA, Neut, WB: Tested |
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| ONCOSTATIN M ANTIBODY TARGET DESCRIPTION: |
Synonym Names for Oncostatin M antibody: Oncostatin M; Mouse monoclonal [17001.31] to Oncostatin M; Oncostatin-M
Oncostatin M (OSM) is a growth-regulating cytokine that affects a number of tumor and normal cells. OSM was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. Recombinant human OSM is produced from a DNA sequence encoding the mature 196 amino acid residue of human OSM. Oncostatin M acts synergistically with TGF-beta-1 to inhibit the proliferation of A375 melanoma cells. Oncostatin M is secreted by macrophages and activated T lymphocytes. It affects a wide variety of normal and tumor cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM will induce cultured human endothelial cells to increase IL6 production. It activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. Oncostatin M, LIF, GCSF, IL6 and ciliary neurotrophic factor (CNTF) are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components.
Function: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST).
Subcellular Location: Secreted.
Similarity: Belongs to the LIF/OSM family.
Oncostatin M [17001.31] reacts with cross-reacts with human. does not cross-react with mouse. not yet tested in other species..
OMIM: 165095; gene. [NCBI / EBI]
Pathways:
KEGG pathway: Cytokine-cytokine receptor interaction 04060
KEGG pathway: Jak-STAT signaling pathway 04630
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: Oncostatin M antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of Oncostatin M antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Oncostatin M antibody, all related information, articles, resources about Oncostatin M antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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