Alphabetical Listing of Primary Antibodies:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
f
|
0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
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P
|
Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
|
Secondary Antibodies
|
ELISA Kits
Gelsolin [GS-2C4] Antibody, Mouse Monoclonal Antibody
Catalog Number: 20-272-190365
Buy Gelsolin antibody -
Volume:
0.1 ml ($360.00)
Related Product Names:
- Gelsolin antibody; Gelsolin; 2934; GSN; 105120; P06396; DKFZp313L0718;; Gelsolin [GS-2C4]
- Mouse monoclonal [GS - 2C4] to Gelsolin; 2934; GSN; 105120; P06396; DKFZp313L0718;; Gelsolin
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
Gelsolin
Gene Name Synonym:
2934; GSN; 105120; P06396; DKFZp313L0718;
Gi #:
N/A
NCBI Acc #:
NP_000168.1
Swiss Prot Acc #:
P06396
Length (aa):
N/A
Mol. Weight (Da):
85698
Chrom Location:
N/A
Clone:
GS-2C4
Isotype:
IgG1
Immunogen:
Full length native protein (purified) (Human).
Antigen Species:
Human
Epitope:
The antibody is directed against an epitope located on the 47 kD peptide derived from a chymotryptic cleavage of gelsolin. This peptide contains the carboxy terminal actin binding site for gelsolin.
Target:
Gelsolin
Localization:
Cytoplasmic and Secreted
Storage Buffer:
Preservative: 15mM Sodium Azide
Application Note:
AP: Use at an assay dependent dilution. ELISA: Use at an assay dependent dilution. IF: Use at an assay dependent dilution. WB: Use at a dilution of 1/1000. Predicted molecular weight: 86 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Cellular Localization:
Cytoplasmic and Secreted
Source/Host:
Mouse
Purity/Purification:
Ascites
Clonality:
Monoclonal
Crossreactivity:
Cross-reacts with Human, Cow, Pig and Rabbit. Not yet tested in other species.
Storage:
For continuous use, store 2-8C for up to one month. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for GELSOLIN ANTIBODY:
AP, ELISA, IF, WB: Tested
TESTING: (
secondary reagents
and
protocols
)
Not Available
GELSOLIN ANTIBODY TARGET DESCRIPTION:
Synonym Names for Gelsolin antibody:
Gelsolin; 2934; GSN; 105120; P06396; DKFZp313L0718;; Mouse monoclonal [GS - 2C4] to Gelsolin; 2934; GSN; 105120; P06396; DKFZp313L0718;; Gelsolin
Gelsolin is a calcium dependent actin binding protein. It is a potent modulator of actin filament length and gelation. Gelsolin has been shown to exist in at least two variant forms, cytoplasmic gelsolin and plasma gelsolin. Plasma gelsolin has also been called actin depolymerizing factor (ADF) or brevin. Human plasma and rabbit macrophage gelsolins differ by the presence of a 25 amino acid residue extension at the NH2 terminus in the human plasma gelsolin which appears to account for the difference in relative molecular weights.
Function:
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.
Subunit:
Binds to actin and to fibronectin.
Subcellular Location:
Isoform 2: Cytoplasm, cytoskeleton.
Subcellular Location:
Isoform 1: Secreted.
Tissue Specificity:
Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
Ptm:
Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.
Disease:
Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
Similarity:
Belongs to the villin/gelsolin family.
Similarity:
Contains 6 gelsolin-like repeats.
Gelsolin [GS-2C4] reacts with cross-reacts with human, cow, pig and rabbit. not yet tested in other species..
OMIM:
105120; phenotype. [
NCBI
/
EBI
]
137350; gene. [
NCBI
/
EBI
]
Pathways:
KEGG pathway: Regulation of actin cytoskeleton
04810
Reactome Event:
Apoptosis
109581
Products similar to Gelsolin antibody:
IgG
Bad phospho S112, IgG
Filensin [FIL-7B10], IgG
Bad phospho S112 antibody, IgG
PRODUCT INTERACTIONS:
Gelsolin [GS-2C4]
interacts
with
beta 1 Arrestin phospho S412, IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
Caspase-4, IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
Caspase-4, IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
CASPASE-4, IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
CASPASE-4, IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
Rabbit anti Caspase 4 (NT), IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
Rabbit anti Caspase 4 (Middle), IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
Caspase 4 [CAS4], IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
Caspase 4, IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
MDM2 [2A10], IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
MDM2 [SMP14], IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
MDM2 [SMP14], IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
Rabbit anti Mouse MDM2 pS185, IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
MDM2 [HDM2-323], IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
MDM2 [MD-219], IgG
(GenWay Catalog #: 20-272-190365)
.
Gelsolin [GS-2C4]
interacts
with
MDM2 (ready-to-use), IgG
(GenWay Catalog #: 20-272-190365)
.
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
Gelsolin antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of Gelsolin antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Gelsolin antibody, all related information, articles, resources about Gelsolin antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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