RANK antibody, RANK [LOB14-8] Antibody, Rat Monoclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

RANK [LOB14-8] Antibody, Rat Monoclonal Antibody

Catalog Number: 20-272-190585

Buy RANK antibody -

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Related Product Names:

- RANK antibody; RANK; 21934; Tnfrsf11a; Ly109; ODFR; OFE; Rank; TRANCE-R; mRANK;; RANK [LOB14-8]
- Rat monoclonal [LOB14 - 8] to RANK; 21934; Tnfrsf11a; Ly109; ODFR; OFE; Rank; TRANCE-R; mRANK;; Tumor necrosis factor receptor superfamily member 11A

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: RANK	Gene Name Synonym: 21934; Tnfrsf11a; Ly109; ODFR; OFE; Rank; TRANCE-R; mRANK;
Gi #: N/A	NCBI Acc #: NP_003830.1	Swiss Prot Acc #: Q9Y6Q6
Length (aa): N/A	Mol. Weight (Da): 66034	Chrom Location: N/A

Clone: LOB14-8

Isotype: IgG2a

Immunogen: RANK-Fc fusion protein (Mouse).

Antigen Species: Mouse

Specificity: ab11544 recognises murine RANK.

Target: RANK

Localization: Cell Membrane

Concentration: Lot specific and is stated on the vial

Purification Note: Purified IgG prepared by affinity chromatography from tissue culture supernatant.

Storage Buffer: Preservative: 0.09% Sodium Azide; Constituents: PBS

Application Note: ELISA: Use at a concentration of 20 ug/ml. FACS: Use at a concentration of 20 ug/ml. Use 20ul of this dilution to label 10E6 cells in 100ul. IP: Use at a concentration of 20 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Cell Membrane

Myeloma: NS1

Source/Host: Rat

Purity/Purification: Protein G purified

Clonality: Monoclonal

Crossreactivity: Cross-reacts with Mouse. Not yet tested in other species.

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for RANK ANTIBODY:

ELISA, FACS, IP: Tested

TESTING: (secondary reagents and protocols )

Not Available

RANK ANTIBODY TARGET DESCRIPTION:

Synonym Names for RANK antibody: RANK; 21934; Tnfrsf11a; Ly109; ODFR; OFE; Rank; TRANCE-R; mRANK;; Rat monoclonal [LOB14 - 8] to RANK; 21934; Tnfrsf11a; Ly109; ODFR; OFE; Rank; TRANCE-R; mRANK;; Tumor necrosis factor receptor superfamily member 11A

RANK is a member of the tumor necrosis factor receptor (TNFR) family. The full length mouse RANK cDNA encodes a type I transmembrane protein with an extracellular and a cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNFR family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains. RANK is widely expressed, with highest levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. RANK is also expressed in dendritic cells. RANK and RANK ligand (RANKL) are important regulators of interactions between T cells and dendritic cells. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of RANK. TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated by RANK include activation of NFkappaB and cjun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis. The soluble form of RANK is able to block TRANCE induced biological activity. The binding of anti-RANK to cell surface RANK triggers signal transduction and induces RANK mediated bioactivity.

Function: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.

Subunit: Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.

Subcellular Location: Membrane; Single-pass type I membrane protein (Potential).

Tissue Specificity: Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Disease: Defects in TNFRSF11A are the cause of familial expansile osteolysis (FEO) [MIM:174810]. FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. The osteolytic lesions develop usually in the long bones during early adulthood. FEO is often associated with early onset deafness and loss of dentition.

Disease: Defects in TNFRSF11A are a cause of Paget disease of bone 2 (PDB2) [MIM:602080]; also known as familial Paget disease of bone. PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Unlike FEO, however, affected individuals have involvement of the axial skeleton with lesions in the spine, pelvis and skull.

Disease: Defects in TNFRSF11A are the cause of autosomal recessive osteopetrosis type 7 (OPTB7) [MIM:612301]; also called osteoclast-poor osteopetrosis with hypogammaglobulinemia. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts.

Similarity: Contains 4 TNFR-Cys repeats.

RANK [LOB14-8] reacts with cross-reacts with mouse. not yet tested in other species..

OMIM: 174810; phenotype. [NCBI / EBI]
602080; phenotype. [NCBI / EBI]
603499; gene. [NCBI / EBI]
612301; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Cytokine-cytokine receptor interaction 04060

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PRODUCT INTERACTIONS:

RANK [LOB14-8] interacts with CD120b. TNF-RII (p75/p80), IgG (GenWay Catalog #: 20-272-190585).

RANK [LOB14-8] interacts with TRAF2 [33A1293], IgG (GenWay Catalog #: 20-272-190585).

RANK [LOB14-8] interacts with Rabbit anti TRAF-2, IgG (GenWay Catalog #: 20-272-190585).

RANK [LOB14-8] interacts with TRAF5 [55A219], IgG (GenWay Catalog #: 20-272-190585).

RANK [LOB14-8] interacts with TNF receptor-associated factor 6, IgG (GenWay Catalog #: 20-272-190585).

RANK [LOB14-8] interacts with TRAF6, IgG (GenWay Catalog #: 20-272-190585).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: RANK antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of RANK antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about RANK antibody, all related information, articles, resources about RANK antibody are being stored on our online database. Let us know if you have questions regarding this product.

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