NAK antibody, NAK [108A429] Antibody, Mouse Monoclonal Antibody

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NAK [108A429] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-190722

Buy NAK antibody -

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Related Product Names:

- NAK antibody; NAK; 29110; TBK1; 604834; Q9UHD2; FLJ11330; NAK; T2K;; NAK [108A429]
- Mouse monoclonal [108A429] to NAK; 29110; TBK1; 604834; Q9UHD2; FLJ11330; NAK; T2K;; Serine/threonine-protein kinase TBK1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: NAK	Gene Name Synonym: 29110; TBK1; 604834; Q9UHD2; FLJ11330; NAK; T2K;
Gi #: N/A	NCBI Acc #: NP_037386.1	Swiss Prot Acc #: Q9UHD2
Length (aa): N/A	Mol. Weight (Da): 83642	Chrom Location: N/A

Clone: 108A429

Isotype: IgG1

Immunogen: Full length protein (Human).

Antigen Species: Human

Specificity: GTX12116 recognises human NAK.

Positive Control: 293 cell extracts transfected with human TBK1 cDNA

Target: NAK

Localization: Cytoplasmic

Concentration: 0.5 mg/ml

Purification Note: Affinity purified.

Storage Buffer: Preservative: 0.02% Sodium Azide; Constituents: PBS

Application Note: WB: Use at a concentration of 1 - 2 µg/ml. Detects a band of approximately 80 kDa (predicted molecular weight: 87.5 kDa). For optimal results, primary antibody incubations should be performed at room temperature. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Cytoplasmic

Source/Host: Mouse

Purity/Purification: Protein G purified

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for NAK ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

NAK ANTIBODY TARGET DESCRIPTION:

Synonym Names for NAK antibody: NAK; 29110; TBK1; 604834; Q9UHD2; FLJ11330; NAK; T2K;; Mouse monoclonal [108A429] to NAK; 29110; TBK1; 604834; Q9UHD2; FLJ11330; NAK; T2K;; Serine/threonine-protein kinase TBK1

Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. Phosphorylation of I-kB by IkB kinase (IKK) complex leads to degradation of I-kB and activation of NF-kB. The IKK complex contains IKKa,IKKb, and IKKg. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-kB-activating kinase), and T2K. NAK/TBK1 activates IKKb through direct phosphorylation. NAK/TBK1is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.

Function: Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively.

Catalytic Activity: ATP + a protein = ADP + a phosphoprotein.

Subunit: Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between TBK1 and SIKE. Interacts with HCV NS3, a hepatitis C virus protein and with BDV P protein, a Borna disease virus protein.

Subcellular Location: Cytoplasm.

Tissue Specificity: Ubiquitous with higher expression in testis.

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.

Similarity: Contains 1 protein kinase domain.

NAK [108A429] reacts with human - not yet tested in other species.

OMIM: 604834; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Toll-like receptor signaling pathway 04620
Reactome Event:Signaling in Immune system 168256

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PRODUCT INTERACTIONS:

NAK [108A429] interacts with Baculoviral IAP repeat-containing protein 4, IgG (GenWay Catalog #: 20-272-190722).

NAK [108A429] interacts with XIAP, IgG (GenWay Catalog #: 20-272-190722).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

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Precautions: NAK antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of NAK antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about NAK antibody, all related information, articles, resources about NAK antibody are being stored on our online database. Let us know if you have questions regarding this product.

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