IKK beta antibody, IKK beta [10AG2] Antibody, Mouse Monoclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

IKK beta [10AG2] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-190733

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Related Product Names:

- IKK beta antibody; IKK beta; I kappa B kinase 2 I kappa B kinase beta IkBKB IKK2 IKKB Inhibitor of kappa light chain gene enhancer in B cells Inhibitor of ka; IKK beta [10AG2]
- Mouse monoclonal [10AG2] to IKK beta; Inhibitor of nuclear factor kappa-B kinase subunit beta

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: IKK beta	Gene Name Synonym: I kappa B kinase 2 I kappa B kinase beta IkBKB IKK2 IKKB Inhibitor of kappa light chain gene enhancer in B cells Inhibitor of ka
Gi #: N/A	NCBI Acc #: NP_001547.1	Swiss Prot Acc #: O14920
Length (aa): N/A	Mol. Weight (Da): 86564	Chrom Location: N/A

Clone: 10AG2

Isotype: IgG1

Immunogen: This antibody was raised against the 6xHis tag full-length proteincorresponding to human IKK beta.

Antigen Species: Human

Positive Control: Daudi whole cell extract

Target: IKK beta

Localization: Cytoplasmic

Concentration: 0.5 mg/ml

Purification Note: This antibody is affinity purified.

Storage Buffer: Preservative: 0.02% Sodium Azide; Constituents: PBS

Application Note: WB: Use at a concentration of 1-2 µg/ml. Detects a band of approximately 87 kDa (predicted molecular weight: 90.7 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Cytoplasmic

Source/Host: Mouse

Purity/Purification: Protein G purified

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for IKK BETA ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

IKK BETA ANTIBODY TARGET DESCRIPTION:

Synonym Names for IKK beta antibody: IKK beta; I kappa B kinase 2 I kappa B kinase beta IkBKB IKK2 IKKB Inhibitor of kappa light chain gene enhancer in B cells Inhibitor of ka; Mouse monoclonal [10AG2] to IKK beta; Inhibitor of nuclear factor kappa-B kinase subunit beta

NFkB is associated with IkB proteins in the cell cytoplasm, which inhibit NFkB activity. The IkB kinase (IKK) phosphorylates IkB, and mediates IkB degradation and NFkB activation. IKK is a serine protein kinase. The beta subunit is part of the IKK complex.

Function: Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.

Catalytic Activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].

Subunit: Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with SQSTM1 through PRKCZ or PRKCI. Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6. May interact with MAVS/IPS1. Interacts with NALP2. Interacts with TICAM1. Interacts with Yersinia yopJ. Interacts with FAF1; the interaction disrupts the IKK complex formation. Interacts with ATM. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with NIBP; the interaction is direct.

Subcellular Location: Cytoplasm.

Tissue Specificity: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.

Ptm: Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-181 by MEKK1 and/or MAP3K14/NIK; which enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which decreases activity and prevents prolonged activation of the inflammatory response.

Ptm: Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, which blocks the I-kappa-B signaling pathway.

Ptm: Ubiquitination on 'Ser-163' modulates phosphorylation on C-terminal serine residues.

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.

Similarity: Contains 1 protein kinase domain.

IKK beta [10AG2] reacts with human - not yet tested in other species.

OMIM: 603258; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Adipocytokine signaling pathway 04920
KEGG pathway: Apoptosis 04210
KEGG pathway: B cell receptor signaling pathway 04662
KEGG pathway: Chronic myeloid leukemia 05220
KEGG pathway: Epithelial cell signaling in Helicobacter pylori infection 05120
KEGG pathway: Insulin signaling pathway 04910
KEGG pathway: MAPK signaling pathway 04010
KEGG pathway: Pancreatic cancer 05212
KEGG pathway: Prostate cancer 05215
KEGG pathway: Small cell lung cancer 05222
KEGG pathway: T cell receptor signaling pathway 04660
KEGG pathway: Toll-like receptor signaling pathway 04620
KEGG pathway: Type II diabetes mellitus 04930
Reactome Event:Signaling in Immune system 168256
Reactome Event:Signalling by NGF 166520

Products similar to IKK beta antibody:

IgG

IKK beta [10A9B6], IgG

PRODUCT INTERACTIONS:

IKK beta [10AG2] interacts with Inhibitor of nuclear factor kappa-B kinase alpha subunit, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKK, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKK alpha [14A231], IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKK -alpha (Phospho-Thr23), IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKK -alpha (Ab-23), IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKK -alpha (Phospho-Thr23) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with Rabbit A' IKK-alpha, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKK-alpha Control Peptide, Peptide (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with Anti-IKK alpha, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with Anti-IKK alpha CONTROL PEPTIDE, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKK alpha phospho S176, S180, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with NF-kappa-B essential modulator, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKK gamma [46B844], IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells. kinase gamma), IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKK gamma, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with Rabbit anti VISA, N-term, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with Rabbit anti VISA (Middle), IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with SRC3, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with NCOA3 [AX 15], IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with NCOA3 [0.T.198], IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with SRC3, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with NF KAPPA B INHIBITOR ALPHA, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with NF KAPPA B INHIBITOR, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKB alpha [6A920], IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKB alpha phospho S32, S36 [39A1431], IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKB alpha cleaved, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with I-kappaB-alpha (Phospho-Tyr42), IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with I-kappaB-alpha (Ab-42), IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with I-kappaB-alpha (Ab-32/36), IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IkappaB-alpha (Phospho-Ser32/Ser36) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IkappaB-alpha (Phospho-Tyr42) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with NFKBIA, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with Rabbit anti IkB-alpha (C-terminal), IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IkB-alpha (C-terminal) Control Peptide, Peptide (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with Anti-IKB alpha (Human MOUSE Rat Specific) C-terminal, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKB alpha, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with IKB alpha phospho S32, S36, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with BKS, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with Hamartin, IgG (GenWay Catalog #: 20-272-190733).

IKK beta [10AG2] interacts with TSC1, IgG (GenWay Catalog #: 20-272-190733).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: IKK beta antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of IKK beta antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about IKK beta antibody, all related information, articles, resources about IKK beta antibody are being stored on our online database. Let us know if you have questions regarding this product.

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