HDAC4 antibody, HDAC4 [HDAC-144] Antibody, Mouse Monoclonal Antibody

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HDAC4 [HDAC-144] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-190739

Buy HDAC4 antibody -

Volume:

Related Product Names:

- HDAC4 antibody; HDAC4; 9759; HDAC4; 605314; P56524; HA6116; HD4; HDAC-A; HDACA; KIAA0288;; HDAC4 [HDAC-144]
- Mouse monoclonal [HDAC - 144] to HDAC4; 9759; HDAC4; 605314; P56524; HA6116; HD4; HDAC-A; HDACA; KIAA0288;; Histone deacetylase 4

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: HDAC4	Gene Name Synonym: 9759; HDAC4; 605314; P56524; HA6116; HD4; HDAC-A; HDACA; KIAA0288;
Gi #: N/A	NCBI Acc #: NP_006028.2	Swiss Prot Acc #: P56524
Length (aa): N/A	Mol. Weight (Da): 119070	Chrom Location: N/A

Clone: HDAC-144

Isotype: IgG2a

Immunogen: Synthetic peptide: MSSQSHPDGLSGRDQPVEL, corresponding to amino acids 1-19 of Human HDAC4 conjugated to KLH with C-terminal added lysine.

Antigen Species: Human

Positive Control: Total cell extracts of NIH3T3 fibroblast cells.

Target: HDAC4

Localization: Cytoplasmic and Nuclear

Concentration: 2.2 mg/ml

Storage Buffer: Preservative: 15mM Sodium Azide; Constituents: 0.01M PBS. pH 7.4

Application Note: ELISA: Use at an assay dependent dilution. ICC: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at a concentration of 1 - 2 µg/ml, this concentration is recommended using total cell extracts of NIH3T3 fibroblast cells. Predicted molecular weight: 140 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Cytoplasmic and Nuclear

Source/Host: Mouse

Purity/Purification: Protein A purified

Clonality: Monoclonal

Crossreactivity: Cross-reacts with Human, Mouse and Rat. Expected to cross-react with Chicken (100% identity with immunogen) due to sequence homology. Not yet tested in other species.

Storage: Aliquot and store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for HDAC4 ANTIBODY:

ELISA, ICC, IP, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

HDAC4 ANTIBODY TARGET DESCRIPTION:

Synonym Names for HDAC4 antibody: HDAC4; 9759; HDAC4; 605314; P56524; HA6116; HD4; HDAC-A; HDACA; KIAA0288;; Mouse monoclonal [HDAC - 144] to HDAC4; 9759; HDAC4; 605314; P56524; HA6116; HD4; HDAC-A; HDACA; KIAA0288;; Histone deacetylase 4

Chromatin is a highly specialized structure composed of tightly compacted chromosomal DNA. Gene expression within the nucleus is controlled, in part, by a host of protein complexes which continuously pack and unpack the chromosomal DNA. One of the known mechanisms of this packing and unpacking process involves the acetylation and deacetylation of the histone proteins comprising the nucleosomal core. Acetylated histone proteins confer accessibility of the DNA template to the transcriptional machinery for expression. Histone deacetylases (HDACs) are chromatin remodeling factors that deacetylate histone proteins and thus, may act as transcriptional repressors. HDACs are classified by their sequence homology to the yeast HDACs and there are currently 2 classes. Class I proteins are related to Rpd3 and members of class II resemble Hda1p.

Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Catalytic Activity: Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subunit: Interacts with HDAC7 (By similarity). Homodimer. Homodimerization via its N-terminal domain. Interacts with MEF2C, AHRR, and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B (By similarity). Interacts with JARID1B.

Subcellular Location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4. The nuclear localization probably depends on sumoylation.

Tissue Specificity: Ubiquitous.

Domain: The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.

Ptm: Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues is required for the interaction with 14-3-3.

Ptm: Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.

Similarity: Belongs to the histone deacetylase family. Type 2 subfamily.

HDAC4 [HDAC-144] reacts with cross-reacts with human, mouse and rat. expected to cross-react with chicken (100% identity with immunogen) due to sequence homology. not yet tested in other species..

OMIM: 605314; gene. [NCBI / EBI]

Products similar to HDAC4 antibody:

IgG

EHD4, IgG

HDAC4 (Phospho-Ser632), IgG

HDAC4, IgG

NANP, IgG

Peptide

HDAC4 (Phospho-Ser632) Antibody Blocking Peptide, Peptide

PRODUCT INTERACTIONS:

HDAC4 [HDAC-144] interacts with Bcl6 [P1F6], IgG (GenWay Catalog #: 20-272-190739).

HDAC4 [HDAC-144] interacts with Bcl6 [PG-B6P], IgG (GenWay Catalog #: 20-272-190739).

HDAC4 [HDAC-144] interacts with HISTONE H4, IgG (GenWay Catalog #: 20-272-190739).

HDAC4 [HDAC-144] interacts with Anti-Histone H4 pS1, IgG (GenWay Catalog #: 20-272-190739).

HDAC4 [HDAC-144] interacts with HISTONE H4, IgG (GenWay Catalog #: 20-272-190739).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: HDAC4 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of HDAC4 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about HDAC4 antibody, all related information, articles, resources about HDAC4 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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