Ran antibody, Ran [ARAN1] Antibody, Mouse Monoclonal Antibody

Alphabetical Listing of Primary Antibodies:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

Ran [ARAN1] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-190802

Buy Ran antibody -

Volume:

Related Product Names:

- Ran antibody; Ran; 5901; RAN; 601179; P62826; ARA24; Gsp1; TC4;; Ran [ARAN1]
- Mouse monoclonal [ARAN1] to Ran; 5901; RAN; 601179; P62826; ARA24; Gsp1; TC4;; GTP-binding nuclear protein Ran

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Ran	Gene Name Synonym: 5901; RAN; 601179; P62826; ARA24; Gsp1; TC4;
Gi #: N/A	NCBI Acc #: NP_006316.1	Swiss Prot Acc #: P62826
Length (aa): N/A	Mol. Weight (Da): 24423	Chrom Location: N/A

Clone: ARAN1

Isotype: IgG2b

Immunogen: Denatured recombinant protein (Human).

Antigen Species: Human

Positive Control: Jurkat cells extract.

Target: Ran

Localization: Nuclear

Concentration: 2 mg/ml

Purification Note: This antibody is purified from culture supernatant of hybridoma cells, grown in a bioreactor.

Storage Buffer: Preservative: 15mM Sodium Azide; Constituents: 0.01M PBS. pH 7.4

Application Note: ELISA: Use at an assay dependent dilution. ICC: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 25 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Nuclear

Source/Host: Mouse

Purity/Purification: Protein A purified

Clonality: Monoclonal

Crossreactivity: Cross-reacts with Human, Mouse, Xenopus laevis, Cow and Hamster. Not yet tested in other species.

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for RAN ANTIBODY:

ELISA, ICC, IP, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

RAN ANTIBODY TARGET DESCRIPTION:

Synonym Names for Ran antibody: Ran; 5901; RAN; 601179; P62826; ARA24; Gsp1; TC4;; Mouse monoclonal [ARAN1] to Ran; 5901; RAN; 601179; P62826; ARA24; Gsp1; TC4;; GTP-binding nuclear protein Ran

Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Function: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).

Function: Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.

Subunit: Monomer. Also forms a complex with CHC1 and interacts with the AR N-terminal poly-Gln region. The interaction with AR is inversely correlated with the poly-Gln length. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Found in a nuclear export complex with RANBP3 and XPO1. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with RANBP10. In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1. Found in a complex with HTLV-1 Rex, RANBP3 and XPO1.

Subcellular Location: Nucleus. Cytoplasm. Melanosome. Note=Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Tissue Specificity: Expressed in a variety of tissues.

Ptm: The N-terminus is blocked.

Similarity: Belongs to the small GTPase superfamily. Ran family.

Ran [ARAN1] reacts with cross-reacts with human, mouse, xenopus laevis, cow and hamster. not yet tested in other species..

OMIM: 601179; gene. [NCBI / EBI]

Pathways:
Reactome Event:HIV Infection 162906
Reactome Event:Influenza Infection 168254

Products similar to Ran antibody:

IgG

CD254, IgG

HCV NS3, IgG

MiTF [C5], IgG

Glutamyltransferase gamma [SPM398], IgG

CD20 [MEM-97], IgG

PRODUCT INTERACTIONS:

Ran [ARAN1] interacts with RanGEF (RCC1), IgG (GenWay Catalog #: 20-272-190802).

Ran [ARAN1] interacts with Transportin-1, IgG (GenWay Catalog #: 20-272-190802).

Ran [ARAN1] interacts with Transportin 1 [D45], IgG (GenWay Catalog #: 20-272-190802).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: Ran antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Ran antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Ran antibody, all related information, articles, resources about Ran antibody are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved