Fibrinogen antibody, Fibrinogen [49D2] Antibody, Mouse Monoclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

Fibrinogen [49D2] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-191099

Buy Fibrinogen antibody -

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Related Product Names:

- Fibrinogen antibody; Fibrinogen; 2243; FGA; 105200; P02671; Fib2; MGC119422; MGC119423; MGC119425; 2244; FGB; 134830; P02675; MGC104327; MGC120405; 2284; FKBP1P3; Fibrinogen [49D2]
- Mouse monoclonal [49D2] to Fibrinogen; Fibrinogen alpha chain

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Fibrinogen	Gene Name Synonym: 2243; FGA; 105200; P02671; Fib2; MGC119422; MGC119423; MGC119425; 2244; FGB; 134830; P02675; MGC104327; MGC120405; 2284; FKBP1P3
Gi #: N/A	NCBI Acc #: NP_000499.1	Swiss Prot Acc #: P02671
Length (aa): N/A	Mol. Weight (Da): 94973	Chrom Location: N/A

Clone: 49D2

Isotype: IgG2a

Immunogen: fibrinopeptide A conjugated with a carrier protein.

Antigen Species: Human

Target: Fibrinogen

Concentration: 2 mg/ml

Purification Note: Purity tested by electrophoresis.

Storage Buffer: Preservative: 0.1% Sodium Azide; Constituents: PBS

Application Note: ELISA: Use at an assay dependent dilution. EIA: Use at an assay dependent dilution. Can be paired for ELISA with 20-272-190055 Mouse monoclonal [40F11] to Fibrinogen . Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Myeloma: Sp2/0

Source/Host: Mouse

Purity/Purification: Protein A purified

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Storage: Keep as concentrated solution, aliquot and store at 4C. Do not freeze.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for FIBRINOGEN ANTIBODY:

EIA, ELISA: Tested

TESTING: (secondary reagents and protocols )

Not Available

FIBRINOGEN ANTIBODY TARGET DESCRIPTION:

Synonym Names for Fibrinogen antibody: Fibrinogen; 2243; FGA; 105200; P02671; Fib2; MGC119422; MGC119423; MGC119425; 2244; FGB; 134830; P02675; MGC104327; MGC120405; 2284; FKBP1P3; Mouse monoclonal [49D2] to Fibrinogen; Fibrinogen alpha chain

Fibrinogen is the main protein of blood coagulation system. It is a large protein (MW 340 kDa) and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1-16 amino acids) and B (1-17 amino acids) are released by thrombin from the N-terminal parts of alpha- and beta-chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases.

Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.

Subcellular Location: Secreted.

Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.

Ptm: The alpha chain is not glycosylated.

Ptm: Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.

Ptm: About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.

Ptm: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.

Disease: Defects in FGA are a cause of congenital afibrinogenemia [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The majority of cases of afibrinogenemia are due to truncating mutations.

Disease: Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.

Disease: Defects in FGA are a cause of amyloidois type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.

Similarity: Contains 1 fibrinogen C-terminal domain.

Fibrinogen [49D2] reacts with human - not yet tested in other species.

OMIM: 105200; phenotype. [NCBI / EBI]
134820; gene+phenotype. [NCBI / EBI]
202400; phenotype. [NCBI / EBI]

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Precautions: Fibrinogen antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Fibrinogen antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Fibrinogen antibody, all related information, articles, resources about Fibrinogen antibody are being stored on our online database. Let us know if you have questions regarding this product.

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