Hair cortex Cytokeratin antibody, Hair cortex Cytokeratin [AE13] Antibody, Mouse Monoclonal Antibody

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Hair cortex Cytokeratin [AE13] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-191268

Buy Hair cortex Cytokeratin antibody -

Volume:

Related Product Names:

- Hair cortex Cytokeratin antibody; Hair cortex Cytokeratin; KRTA; Hair cortex Cytokeratin [AE13]
- Mouse monoclonal [AE13] to hair cortex Cytokeratin; Keratin, type II cytoskeletal 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Hair cortex Cytokeratin	Gene Name Synonym: KRTA
Gi #: N/A	NCBI Acc #: NP_006112.3	Swiss Prot Acc #: P04264
Length (aa): N/A	Mol. Weight (Da): 66018	Chrom Location: N/A

Clone: AE13

Isotype: IgG

Immunogen: Human hair keratins.

Antigen Species: Human

Specificity: This antibody is specific for the family of hair cortex keratins.

Target: Hair cortex Cytokeratin

Storage Buffer: Phosphate-buffered saline, pH 7.2, containing 0.1% sodium azide

Application Note: For WB: Use at a dilution of 1:1,000 - 1:3,000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Myeloma: P3x63-Ag8.653

Source/Host: Mouse

Purity/Purification: Protein G purified

Clonality: Monoclonal

Crossreactivity: Human and Mouse - Not yet tested in other species

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for HAIR CORTEX CYTOKERATIN ANTIBODY:

IHC-P, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

HAIR CORTEX CYTOKERATIN ANTIBODY TARGET DESCRIPTION:

Synonym Names for Hair cortex Cytokeratin antibody: Hair cortex Cytokeratin; KRTA; Mouse monoclonal [AE13] to hair cortex Cytokeratin; Keratin, type II cytoskeletal 1

This antibody is an excellent marker for hair and nail differentiation.

Function: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1).

Subunit: Heterotetramer of two type I and two type II keratins. Keratin-1 is generally associated with keratin-10. Interacts with ITGB1 in the presence of GNB2L1 and SRC, and with GNB2L1.

Subcellular Location: Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells.

Tissue Specificity: The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.

Ptm: Undergoes deimination of some arginine residues (citrullination).

Polymorphism: There are two size variants of KRT1, termed allele 1A and allele 1B with allelic frequencies of 0.61 and 0.39. Allele 1B lacks 7 residues compared to allele 1A.

Disease: Defects in KRT1 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.

Disease: Defects in KRT1 are the cause of ichthyosis hystrix Curth-Macklin type (IHCM) [MIM:146590]. IHCM is a genodermatosis with severe verrucous hyperkeratosis. Affected individuals manifest congenital verrucous black scale on the scalp, neck, and limbs with truncal erythema, palmoplantar keratoderma and keratoses on the lips, ears, nipples and buttocks.

Disease: Defects in KRT1 are a cause of palmoplantar keratoderma non-epidermolytic (NEPPK) [MIM:600962]. NEPKK is a dermatological disorder characterized by focal palmoplantar keratoderma with oral, genital, and follicular lesions.

Disease: Defects in KRT1 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.

Disease: Defects in KRT1 are the cause of palmoplantar keratoderma striate type 3 (SPPK3) [MIM:607654]; also known as keratosis palmoplantaris striata III. SPPK3 is a dermatological disorder affecting palm and sole skin where stratum corneum and epidermal layers are thickened. There is no involvement of non-palmoplantar skin, and both hair and nails are normal.

Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Similarity: Belongs to the intermediate filament family.

Hair cortex Cytokeratin [AE13] reacts with human and mouse - not yet tested in other species.

OMIM: 113800; phenotype. [NCBI / EBI]
139350; gene. [NCBI / EBI]
146590; phenotype. [NCBI / EBI]
600962; phenotype. [NCBI / EBI]
607602; phenotype. [NCBI / EBI]
607654; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Cell Communication 01430

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PRODUCT INTERACTIONS:

Hair cortex Cytokeratin [AE13] interacts with MDM2 [2A10], IgG (GenWay Catalog #: 20-272-191268).

Hair cortex Cytokeratin [AE13] interacts with MDM2 [SMP14], IgG (GenWay Catalog #: 20-272-191268).

Hair cortex Cytokeratin [AE13] interacts with Rabbit anti Mouse MDM2 pS185, IgG (GenWay Catalog #: 20-272-191268).

Hair cortex Cytokeratin [AE13] interacts with MDM2 [HDM2-323], IgG (GenWay Catalog #: 20-272-191268).

Hair cortex Cytokeratin [AE13] interacts with MDM2 [MD-219], IgG (GenWay Catalog #: 20-272-191268).

Hair cortex Cytokeratin [AE13] interacts with MDM2 (ready-to-use), IgG (GenWay Catalog #: 20-272-191268).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

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Precautions: Hair cortex Cytokeratin antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Hair cortex Cytokeratin antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

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