NALP3 antibody, NALP3 [nalpy3-b] Antibody, Mouse Monoclonal Antibody

Alphabetical Listing of Primary Antibodies:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

NALP3 [nalpy3-b] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-191451

Buy NALP3 antibody -

Size:

Related Product Names:

- NALP3 antibody; NALP3; 114548; CIAS1; 120100; Q96P20; AGTAVPRL; AII/AVP; C1orf7; FCAS; FCU; MWS; NALP3; PYPAF1;; NALP3 [nalpy3-b]
- Mouse monoclonal [nalpy3-b] to NALP3; 114548; CIAS1; 120100; Q96P20; AGTAVPRL; AII/AVP; C1orf7; FCAS; FCU; MWS; NALP3; PYPAF1;; NACHT, LRR and PYD domains-containing protein 3

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: NALP3	Gene Name Synonym: 114548; CIAS1; 120100; Q96P20; AGTAVPRL; AII/AVP; C1orf7; FCAS; FCU; MWS; NALP3; PYPAF1;
Gi #: N/A	NCBI Acc #: NP_001073289.1	Swiss Prot Acc #: Q96P20
Length (aa): N/A	Mol. Weight (Da): 117913	Chrom Location: N/A

Clone: nalpy3-b

Isotype: IgG1

Immunogen: Recombinant human NALP3 (NACHT-, LRR- and PYD-containingprotein 3) (pyrin domain).

Antigen Species: Human

Specificity: Recognizes human NALP3. Detects endogenous protein by IP and WB.

Target: NALP3

Concentration: 1 mg/ml

Storage Buffer: Preservative: 0.02% Sodium Azide. Constituents: PBS

Application Note: IP: 1/50. WB: 1/1000. Predicted molecular weight: 118 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Source/Host: Mouse

Purity/Purification: Tissue culture supernatant

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for NALP3 ANTIBODY:

IP, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

NALP3 ANTIBODY TARGET DESCRIPTION:

Synonym Names for NALP3 antibody: NALP3; 114548; CIAS1; 120100; Q96P20; AGTAVPRL; AII/AVP; C1orf7; FCAS; FCU; MWS; NALP3; PYPAF1;; Mouse monoclonal [nalpy3-b] to NALP3; 114548; CIAS1; 120100; Q96P20; AGTAVPRL; AII/AVP; C1orf7; FCAS; FCU; MWS; NALP3; PYPAF1;; NACHT, LRR and PYD domains-containing protein 3

This gene encodes a pyrin like protein which contains a pyrin domain, a nucleotide binding site (NBS) domain, and a leucine rich repeat (LRR) motif. This protein interacts with apoptosis associated speck like protein containing a CARD. Proteins which contain the caspase recruitment domain, CARD, have been shown to be involved in inflammation and immune response. This protein may function as an activator of NF-kappaB signaling. The encoded protein may play a role in the regulation of inflammation and apoptosis. Mutations in this gene have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Two transcript variants encoding distinct isoforms have been identified for this gene.

Function: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.

Subunit: Interacts with PYCARD/ASC. Part of the NALP3 inflammasome complex which is involved in activation of caspase-1 and caspase-5, leading to processing of IL1B and IL18.

Subcellular Location: Cytoplasm.

Tissue Specificity: Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells and osteoblasts. Undetectable or expressed at a lower magnitude in B- and T-lymphoblasts, respectively. High level of expression detected in chondrocytes. Detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder.

Induction: By TNF-alpha.

Disease: Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1) [MIM:120100]; commonly known as familial cold urticaria. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.

Disease: Defects in NLRP3 are a cause of Muckle-Wells syndrome (MWS) [MIM:191900]; also known as urticaria-deafness-amyloidosis syndrome. MWS is a hereditary periodic fever syndrome characterized by fever, chronic recurrent urticaria, arthralgias, progressive sensorineural deafness, and reactive renal amyloidosis. The disease may be severe if generalized amyloidosis occurs.

Disease: Defects in NLRP3 are the cause of chronic infantile neurologic cutaneous and articular syndrome (CINCA) [MIM:607115]; also known as 'neonatal onset multisystem inflammatory disease,' or NOMID, a rare congenital inflammatory disorder characterized by a triad of neonatal onset of cutaneous symptoms, chronic meningitis, and joint manifestations with recurrent fever and inflammation.

Similarity: Belongs to the NLRP family.

Similarity: Contains 1 DAPIN domain.

Similarity: Contains 7 LRR (leucine-rich) repeats.

Similarity: Contains 1 NACHT domain.

NALP3 [nalpy3-b] reacts with human - not yet tested in other species.

OMIM: 120100; phenotype. [NCBI / EBI]
191900; phenotype. [NCBI / EBI]
606416; gene. [NCBI / EBI]
607115; phenotype. [NCBI / EBI]

Products similar to NALP3 antibody:

IgG

NALP3 [Nalpy3-a], IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: NALP3 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of NALP3 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about NALP3 antibody, all related information, articles, resources about NALP3 antibody are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved