|
|
| Osteoprotegerin [bony-1] Antibody, Rat Monoclonal Antibody |
 |
|
|
 |
| Catalog Number: 20-272-191596 |
|
|
|
| Related Product Names:
|
-
Osteoprotegerin antibody; Osteoprotegerin; OCIF; OPG; Osteoprotegerin [bony-1]
- Rat monoclonal [bony-1] to Osteoprotegerin; Tumor necrosis factor receptor superfamily member 11B |
|
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
|
|
| Gene Name: Osteoprotegerin |
Gene Name Synonym: OCIF; OPG |
Gi #:
N/A |
NCBI Acc #:
NP_002537.3 |
Swiss Prot Acc #:
O00300 |
Length (aa): N/A |
Mol. Weight (Da): 46040 |
Chrom Location: N/A |
|
|
 Clone: bony-1
Isotype: IgG2a
Immunogen: Recombinant fragment, corresponding to amino acids 22-202 of Human Osteoprotegerin.
Antigen Species: Human
Specificity: Recognizes human OPG
Target: Osteoprotegerin
Localization: Secreted
Concentration: 1 mg/ml
Storage Buffer: Preservative: 0.02% Sodium Azide. Constituents: PBS
Application Note: FACS: 1/1000. IP: 1/200. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Cellular Localization: Secreted
Source/Host: Rat
Purity/Purification: >95% by SDS-PAGE
Clonality: Monoclonal
Crossreactivity: Human - Not yet tested in other species
Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
|
| APPLICATIONS for OSTEOPROTEGERIN ANTIBODY: |
| FACS, IP: Tested |
|
|
|
|
| OSTEOPROTEGERIN ANTIBODY TARGET DESCRIPTION: |
Synonym Names for Osteoprotegerin antibody: Osteoprotegerin; OCIF; OPG; Rat monoclonal [bony-1] to Osteoprotegerin; Tumor necrosis factor receptor superfamily member 11B
Osteoprotegerin (OPG) is a member of the TNF receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of the gene have been reported, but their full length nature has not been determined.
Function: Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
Subunit: Homodimer.
Subcellular Location: Secreted.
Tissue Specificity: Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Induction: Up-regulated by increasing calcium-concentration in the medium and estrogens. Down-regulated by glucocorticoids.
Ptm: N-glycosylated. Contains sialic acid residues.
Ptm: The N-terminus is blocked.
Disease: Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also called hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast-mediated skeletal resorption, the disease can be fatal.
Similarity: Contains 2 death domains.
Similarity: Contains 4 TNFR-Cys repeats.
Osteoprotegerin [bony-1] reacts with human - not yet tested in other species.
OMIM: 239000; phenotype. [NCBI / EBI]
602643; gene. [NCBI / EBI]
Pathways:
KEGG pathway: Cytokine-cytokine receptor interaction 04060
Products similar to Osteoprotegerin antibody:
IgG
 Rabbit anti sRANK Ligand, IgG
Osteoprotegerin, IgG
Osteoprotegerin [OPG 01], IgG
CD254, IgG
CD254, IgG
Protein
OPG Human, His, Protein
sRANKL Human, Protein
CD254, Protein
OPG-Fc Human, Protein
CD254, Protein
|
|
|
SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
|
|
Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: Osteoprotegerin antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of Osteoprotegerin antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Osteoprotegerin antibody, all related information, articles, resources about Osteoprotegerin antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
|
|
|
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
|
|
Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
|
|
|
