CD11a antibody, CD11a [I21/7] (FITC ) Antibody, Rat Monoclonal Antibody

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CD11a [I21/7] (FITC ) Antibody, Rat Monoclonal Antibody

Catalog Number: 20-272-191829

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Related Product Names:

- CD11a antibody; CD11a; 3683; ITGAL; 153370; P20701; CD11A; LFA-1; LFA1A;; CD11a [I21/7] (FITC )
- Rat monoclonal [I21/7] to CD11a (FITC); 3683; ITGAL; 153370; P20701; CD11A; LFA-1; LFA1A;; Integrin alpha-L

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: CD11a	Gene Name Synonym: 3683; ITGAL; 153370; P20701; CD11A; LFA-1; LFA1A;
Gi #: N/A	NCBI Acc #: NP_001107852.1	Swiss Prot Acc #: P20701
Length (aa): N/A	Mol. Weight (Da): 128770	Chrom Location: N/A

Clone: I21/7

Isotype: IgG2a

Immunogen: Unfortunately, this information is considered to be commercially sensitive

Target: CD11a

Localization: Type I membrane protein.

Conjugation: FITC

Concentration: 0.5 mg/ml

Storage Buffer: Preservative: 0.09% Sodium Azide. Constituents: 1% BSA, 10mM PBS. pH 7.2

Application Note: FACS: Use 1µg for 10^6 cells. IHC-Fr: Use at an assay dependent dilution. Note: Frozen tissues for IHC are fixed with Acetone. IP: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Type I membrane protein.

Source/Host: Rat

Purity/Purification: Protein G purified

Clonality: Monoclonal

Crossreactivity: Cross-reacts with Mouse. Not yet tested in other species.

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for CD11A ANTIBODY:

FACS, IHC-Fr, IP: Tested

TESTING: (secondary reagents and protocols )

Not Available

CD11A ANTIBODY TARGET DESCRIPTION:

Synonym Names for CD11a antibody: CD11a; 3683; ITGAL; 153370; P20701; CD11A; LFA-1; LFA1A;; Rat monoclonal [I21/7] to CD11a (FITC); 3683; ITGAL; 153370; P20701; CD11A; LFA-1; LFA1A;; Integrin alpha-L

CD11a is a glycoprotein expressed in combination with the CD18 beta chain. The complex is a member of the beta2 integrin family. These molecules function in cell adhesion and specifically bind to CD54, ICAM2, ICAM3. CD11a is expressed on lymphocytes, granulocytes, monocytes, and macrophages and is upregulated on activated T cells.

Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

Subunit: Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.

Subcellular Location: Membrane; Single-pass type I membrane protein.

Tissue Specificity: Leukocytes.

Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Similarity: Belongs to the integrin alpha chain family.

Similarity: Contains 7 FG-GAP repeats.

Similarity: Contains 1 VWFA domain.

CD11a [I21/7] (FITC ) reacts with cross-reacts with mouse. not yet tested in other species..

OMIM: 153370; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Cell adhesion molecules (CAMs) 04514
KEGG pathway: Leukocyte transendothelial migration 04670
KEGG pathway: Natural killer cell mediated cytotoxicity 04650
KEGG pathway: Regulation of actin cytoskeleton 04810
Reactome Event:Hemostasis 109582
Reactome Event:Signaling in Immune system 168256

Products similar to CD11a antibody:

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CD18 [C71/16], IgG

alpha Catenin, IgG

CD11a, IgG

Mouse CD11a, IgG

PRODUCT INTERACTIONS:

CD11a [I21/7] (FITC ) interacts with CD50, IgG (GenWay Catalog #: 20-272-191829).

CD11a [I21/7] (FITC ) interacts with ICAM3 [MEM-171], IgG (GenWay Catalog #: 20-272-191829).

CD11a [I21/7] (FITC ) interacts with ICAM3 [ICAM3.1], IgG (GenWay Catalog #: 20-272-191829).

CD11a [I21/7] (FITC ) interacts with CD50, IgG (GenWay Catalog #: 20-272-191829).

CD11a [I21/7] (FITC ) interacts with CD50 [MEM-04], IgG (GenWay Catalog #: 20-272-191829).

CD11a [I21/7] (FITC ) interacts with CD50, IgG (GenWay Catalog #: 20-272-191829).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: CD11a antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of CD11a antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CD11a antibody, all related information, articles, resources about CD11a antibody are being stored on our online database. Let us know if you have questions regarding this product.

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