Transferrin receptor antibody, Transferrin receptor [R17217.1.4] (FITC) Antibody, Rat Monoclonal Antibody

Alphabetical Listing of Primary Antibodies:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

Transferrin receptor [R17217.1.4] (FITC) Antibody, Rat Monoclonal Antibody

Catalog Number: 20-272-191840

Buy Transferrin receptor antibody -

Size:

Related Product Names:

- Transferrin receptor antibody; Transferrin receptor; 22042; Tfrc; 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; Mtvr-1; Mtvr1; TFR; TFR1; Trfr; p90;; Transferrin receptor [R17217.1.4] (FITC)
- Rat monoclonal [R17217.1.4] to Transferrin Receptor (FITC); 22042; Tfrc; 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; Mtvr-1; Mtvr1; TFR; TFR1; Trfr; p90;; Transferrin receptor protein 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Transferrin receptor	Gene Name Synonym: 22042; Tfrc; 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; Mtvr-1; Mtvr1; TFR; TFR1; Trfr; p90;
Gi #: N/A	NCBI Acc #: NP_001121620.1	Swiss Prot Acc #: P02786
Length (aa): N/A	Mol. Weight (Da): 84871	Chrom Location: N/A

Clone: R17217.1.4

Isotype: IgG2a

Immunogen: Full length protein (Mouse).

Antigen Species: Mouse

Specificity: Recognizes the mouse transferrin receptor protein on the surface of most dividing cells. The function of the transferrin receptor is believed to be mainly nutritional. Alternatively, it has been suggested that a growth signal might be provided by the interaction of transferrin and transferrin receptor. The CD71 is present on most dividing cells, including normally cycling in vivo hematopoietic progenitor cells, mitogenically stimulated cells in vitro, some primary tumor cells and most proliferating cells in vitro

Target: Transferrin receptor

Localization: Type II membrane protein. Secreted.

Conjugation: FITC

Concentration: 0.5 mg/ml

Storage Buffer: Preservative: 0.09% Sodium Azide. Constituents: 1% BSA, 0.01M PBS. pH 7.2

Application Note: FACS: Use 1µg for 10^ cells. IP: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Type II membrane protein. Secreted.

Source/Host: Rat

Purity/Purification: Protein G purified

Clonality: Monoclonal

Crossreactivity: Cross-reacts with Mouse. Not yet tested in other species.

Format: Liquid

Storage: Keep as concentrated solution, aliquot and store at 4C. Do not freeze.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for TRANSFERRIN RECEPTOR ANTIBODY:

FACS, IP: Tested

TESTING: (secondary reagents and protocols )

Not Available

TRANSFERRIN RECEPTOR ANTIBODY TARGET DESCRIPTION:

Synonym Names for Transferrin receptor antibody: Transferrin receptor; 22042; Tfrc; 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; Mtvr-1; Mtvr1; TFR; TFR1; Trfr; p90;; Rat monoclonal [R17217.1.4] to Transferrin Receptor (FITC); 22042; Tfrc; 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; Mtvr-1; Mtvr1; TFR; TFR1; Trfr; p90;; Transferrin receptor protein 1

Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Useful in studies of dividing haematopoietic and tumour cell populations, and metabolic activity. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C terminal binding site. The antigen is present on most dividing cells, including normally cycling in vivo hematopoietic progenitor cells, mitogenically stimulated cells in vitro, some primary tumor cells and most proliferating cells in vitro.The transferrin receptor has been structurally characterized as a sulfide-bound dimer of identical glycoprotein subunits of 95 kD. The transferrin receptor is not present on resting blood lymphocytes. On PBL, the receptor appears after activation. The expression of transferrin receptor is coordinately regulated with cell growth. Present on T and B cell lines.

Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Subunit: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3.

Subcellular Location: Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular Location: Transferrin receptor protein 1, serum form: Secreted.

Induction: Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.

Ptm: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.

Ptm: Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).

Ptm: Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.

Miscellaneous: Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

Miscellaneous: Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.

Similarity: Belongs to the peptidase M28 family. M28B subfamily [view classification].

Similarity: Contains 1 PA (protease associated) domain.

Transferrin receptor [R17217.1.4] (FITC) reacts with cross-reacts with mouse. not yet tested in other species..

OMIM: 190010; gene. [NCBI / EBI]

Products similar to Transferrin receptor antibody:

IgG

CD71 [MRC OX-26] (FITC), IgG

CD71 [YTA 74.4], IgG

CD71 [B331 (66IG10)] (FITC), IgG

Transferrin receptor [T56/14] (PE), IgG

Transferrin receptor [7-1], IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: Transferrin receptor antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Transferrin receptor antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Transferrin receptor antibody, all related information, articles, resources about Transferrin receptor antibody are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved