ICAM1 antibody, ICAM1 [15.2] Antibody, Mouse Monoclonal Antibody

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ICAM1 [15.2] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-191958

Buy ICAM1 antibody -

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Related Product Names:

- ICAM1 antibody; ICAM1; BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; intercellular adhesion molecule 1; Major group rhinovirus; ICAM1 [15.2]
- Mouse monoclonal [15.2] to ICAM1; BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; intercellular adhesion molecule 1; Major group rhinovirus receptor; Intercellular adhesion molecule 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: ICAM1	Gene Name Synonym: BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; intercellular adhesion molecule 1; Major group rhinovirus
Gi #: N/A	NCBI Acc #: NP_000192.2	Swiss Prot Acc #: P05362
Length (aa): N/A	Mol. Weight (Da): 57825	Chrom Location: N/A

Clone: 15.2

Isotype: IgG1

Immunogen: Human monocytes.

Antigen Species: Human

Specificity: Blocks binding of LFA-1 & infected RBCs to ICAM1.

Positive Control: Tonsil

Target: ICAM1

Localization: Type I membrane protein

Concentration: 1 mg/ml

Storage Buffer: Phosphate buffered saline

Application Note: FACS: Use at an assay dependent concentration. IHC: Use at an assay dependent concentration. IP: Use at an assay dependent concentration. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Type I membrane protein

Myeloma: Sp2/0

Source/Host: Mouse

Purity/Purification: Protein A purified

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Format: Liquid.

Storage: Store at 4C. Long term (>6months) aliquot and store at -20C. Avoid repeated freeze thawing.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for ICAM1 ANTIBODY:

FACS, IHC, IP: Tested

TESTING: (secondary reagents and protocols )

Not Available

ICAM1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for ICAM1 antibody: ICAM1; BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; intercellular adhesion molecule 1; Major group rhinovirus; Mouse monoclonal [15.2] to ICAM1; BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; intercellular adhesion molecule 1; Major group rhinovirus receptor; Intercellular adhesion molecule 1

ICAM1 is a 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase in inflammation. Also, ICAM1 is detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria.

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Subunit: Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.

Subcellular Location: Membrane; Single-pass type I membrane protein.

Ptm: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Polymorphism: Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.

Similarity: Belongs to the immunoglobulin superfamily. ICAM family.

Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

ICAM1 [15.2] reacts with human - not yet tested in other species.

OMIM: 147840; gene. [NCBI / EBI]

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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: ICAM1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of ICAM1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ICAM1 antibody, all related information, articles, resources about ICAM1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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