Integrin beta 1 antibody, Integrin beta 1 [4B7] Antibody, Mouse Monoclonal Antibody

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Integrin beta 1 [4B7] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-191968

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Related Product Names:

- Integrin beta 1 antibody; Integrin beta 1; cd29; cd29 antigen; fibrinogen receptor beta subunit; fnrb; GPIIA; integrin vla4 beta subunit; itgb1; mdf2; msk12; very late act; Integrin beta 1 [4B7]
- Mouse monoclonal [4B7] to Integrin beta 1; Integrin beta-1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Integrin beta 1	Gene Name Synonym: cd29; cd29 antigen; fibrinogen receptor beta subunit; fnrb; GPIIA; integrin vla4 beta subunit; itgb1; mdf2; msk12; very late act
Gi #: N/A	NCBI Acc #: NP_002202.2	Swiss Prot Acc #: P05556
Length (aa): N/A	Mol. Weight (Da): 88415	Chrom Location: N/A

Clone: 4B7

Isotype: IgG1

Light chain: kappa

Immunogen: Human ocular melanoma cell line V + B2

Antigen Species: Human

Specificity: Specific for integrin beta-1 subunit or CD29, which runs at 110 kDa non-reduced and at 130 kDa reduced.

Positive Control: Human spleen, thymus or tonsil

Target: Integrin beta 1

Localization: Type 1 membrane protein

Concentration: ~1 mg/ml

Storage Buffer: Phosphate-buffered saline

Application Note: FACS: Use at an assay dependent dilution. IF: 1/125 - 1/250. IHC-P: 1/125 - 1/250. IP: Use at 2µg/mg of lysate. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Type 1 membrane protein

Myeloma: P3-NS1/1-Ag4-1

Source/Host: Mouse

Purity/Purification: Protein A purified

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for INTEGRIN BETA 1 ANTIBODY:

FACS, IF, IHC-P, IP: Tested

TESTING: (secondary reagents and protocols )

Not Available

INTEGRIN BETA 1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for Integrin beta 1 antibody: Integrin beta 1; cd29; cd29 antigen; fibrinogen receptor beta subunit; fnrb; GPIIA; integrin vla4 beta subunit; itgb1; mdf2; msk12; very late act; Mouse monoclonal [4B7] to Integrin beta 1; Integrin beta-1

Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6, also known as CD49a, CD49b, CD49c, CD49d, CD49e, and CD49f, respectively) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.

Function: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation.

Subunit: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with KRT1 in the presence of GNB2L1 and SRC. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses.

Subcellular Location: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells.

Tissue Specificity: Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in peripheral T-cells. Isoform beta-1C is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).

Ptm: The cysteine residues are involved in intrachain disulfide bonds (By similarity).

Similarity: Belongs to the integrin beta chain family.

Similarity: Contains 1 VWFA domain.

Integrin beta 1 [4B7] reacts with human - not yet tested in other species.

OMIM: 135630; gene. [NCBI / EBI]

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Precautions: Integrin beta 1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Integrin beta 1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

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