CD147 antibody, CD147 [MEM-M6/1] Antibody, Mouse Monoclonal Antibody

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CD147 [MEM-M6/1] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-192051

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Related Product Names:

- CD147 antibody; CD147; 5F7, Basigin, BSG, Collagenase stimulatory factor, Emmprin, Extracellular matrix metalloproteinase inducer, M6, OK blood group,; CD147 [MEM-M6/1]
- Mouse monoclonal [MEM - M6 / 1] to CD147; 682; BSG; 109480; P35613; 5F7; CD147; EMMPRIN; M6; OK; TCSF;; 682; BSG; 109480; P35613; 5F7; CD147; EMMPRIN; M6; OK; TCSF;

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: CD147	Gene Name Synonym: 5F7, Basigin, BSG, Collagenase stimulatory factor, Emmprin, Extracellular matrix metalloproteinase inducer, M6, OK blood group,
Gi #: N/A	NCBI Acc #: NP_001719.2	Swiss Prot Acc #: P35613
Length (aa): N/A	Mol. Weight (Da): 42200	Chrom Location: N/A

Clone: MEM-M6/1

Isotype: IgG1

Immunogen: Protein A-CR purified soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the hinge region, C_H2-and C_H3 domain of human IgG1 (CD147Rg is secreted by transfectants as a dimer).

Antigen Species: Human

Specificity: Human CD147 antigen. This antibody recognizes an epitope in the N-terminal Ig domain (D1). This high-affinity antibody is capable of binding to unstimulated peripheral blood T cells.

Target: CD147

Concentration: 1 mg/ml

Purification Note: Purified from ascites by protein A-affinity chromatography.

Storage Buffer: Phosphate buffered saline pH 7.4 containing 15mM sodium azide

Application Note: FACS: Use at an assay dependant concentration. IP: Use at an assay dependant concentration. WB: Use at an assay dependant concentration. Use under non-reducing conditions. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Source/Host: Mouse

Purity/Purification: >95% by SDS-PAGE

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for CD147 ANTIBODY:

FACS, IP, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

CD147 ANTIBODY TARGET DESCRIPTION:

Synonym Names for CD147 antibody: CD147; 5F7, Basigin, BSG, Collagenase stimulatory factor, Emmprin, Extracellular matrix metalloproteinase inducer, M6, OK blood group,; Mouse monoclonal [MEM - M6 / 1] to CD147; 682; BSG; 109480; P35613; 5F7; CD147; EMMPRIN; M6; OK; TCSF;; 682; BSG; 109480; P35613; 5F7; CD147; EMMPRIN; M6; OK; TCSF;

Function: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes (By similarity).

Subunit: Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1.

Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Melanosome. Note=Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Tissue Specificity: Present only in vascular endothelium in non-neoplastic regions of the brain whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Induction: Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.

Ptm: N-glycosylated.

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

CD147 [MEM-M6/1] reacts with human - not yet tested in other species.

OMIM: 109480; gene. [NCBI / EBI]
111380; phenotype. [NCBI / EBI]

Pathways:
Reactome Event:Hemostasis 109582
Reactome Event:Signaling in Immune system 168256

Products similar to CD147 antibody:

IgG

CD147 [MEM-M6/2], IgG

CD147 [MRC OX-47], IgG

EMMPRIN, IgG

PRODUCT INTERACTIONS:

CD147 [MEM-M6/1] interacts with DNA-binding protein RFXANK, IgG (GenWay Catalog #: 20-272-192051).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: CD147 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of CD147 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CD147 antibody, all related information, articles, resources about CD147 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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