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| CD47 [B6H12.2] Antibody, Mouse Monoclonal Antibody |
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| Catalog Number: 20-272-192513 |
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| Related Product Names:
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CD47 antibody; CD47; IAP, Integrin Associated Protein,; CD47 [B6H12.2]
- Mouse monoclonal [B6H12.2] to CD47; 961; CD47; 601028; Q08722; IAP; MER6; OA3;; 961; CD47; 601028; Q08722; IAP; MER6; OA3; |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: CD47 |
Gene Name Synonym: IAP, Integrin Associated Protein, |
Gi #:
N/A |
NCBI Acc #:
NP_001020250.1 |
Swiss Prot Acc #:
Q08722 |
Length (aa): N/A |
Mol. Weight (Da): 35214 |
Chrom Location: N/A |
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 Clone: B6H12.2
Isotype: IgG1
Light chain: kappa
Immunogen: Intact CD47 purified from placenta.
Positive Control: Tonsil
Target: CD47
Localization: Cell membrane.
Concentration: 1 mg/ml
Storage Buffer: 10mM PBS, pH7.4. Also available with BSA and sodium azide at 0.2 mg/ml as
Application Note: Flow Cytometry / Immunofluorescence (methanol fixed only) / Functional studies: assay dependent. Immunoprecipitation (native, with protein G): use at a concentration of 2µg / mg protein lysate. Not tested in other applications. Optimal dilutions / concentrations should be determined by the end user. This antibody blocks the binding of SIRP alpha (Yoshida, et al.; Latour et al.) and inhibits in assays where CD47-integrin association is required.
Cellular Localization: Cell membrane.
Source/Host: Mouse
Purity/Purification: Protein G purified
Clonality: Monoclonal
Crossreactivity: Human - Not yet tested in other species
Format: Liquid
Storage: Keep as concentrated solution, aliquot and store at 4C. Do not freeze.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for CD47 ANTIBODY: |
| FACS, FuncS, IF, IP: Tested |
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| CD47 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for CD47 antibody: CD47; IAP, Integrin Associated Protein,; Mouse monoclonal [B6H12.2] to CD47; 961; CD47; 601028; Q08722; IAP; MER6; OA3;; 961; CD47; 601028; Q08722; IAP; MER6; OA3;
CD47 antigen, also known as integrin associated protein (IAP), is expressed on all hematopoietic cells, including leukocytes, platelets and erythrocytes. It is also expressed on epithelial cells, endothelial cells, fibroblasts and many tumor cell lines. CD47 may play a role as a signal transducer in the regulation of cation fluxes across cell membranes and in the chemotactic and adhesive interactions of leukocytes with endothelial cells.
Function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
Subunit: Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.
Subcellular Location: Cell membrane; Multi-pass membrane protein.
Tissue Specificity: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
CD47 [B6H12.2] reacts with human - not yet tested in other species.
OMIM: 601028; gene. [NCBI / EBI]
Pathways:
KEGG pathway: ECM-receptor interaction 04512
Reactome Event:Hemostasis 109582
Reactome Event:Signaling in Immune system 168256
Products similar to CD47 antibody:
IgG
 CD47, IgG
CD47 [MEM-122], IgG
CD47, IgG
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: CD47 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of CD47 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CD47 antibody, all related information, articles, resources about CD47 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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