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Cyclin E [HE12] Antibody, Mouse Monoclonal Antibody Printer Friendly Datasheet
Catalog Number: 20-272-192543
Buy Cyclin E antibody - Volume:   
  Related Product Names:
- Cyclin E antibody; Cyclin E; 898; CCNE1; 123837; P24864; CCNE;; Cyclin E [HE12]
- Mouse monoclonal [HE12] to Cyclin E; 898; CCNE1; 123837; P24864; CCNE;; G1/S-specific cyclin-E1
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
 Gene Name: Cyclin E  Gene Name Synonym: 898; CCNE1; 123837; P24864; CCNE;

 Gi #: N/A
 NCBI Acc #: NP_001229.1
 Swiss Prot Acc #: P24864

 Length (aa): N/A
 Mol. Weight (Da): 47077
 Chrom Location: N/A
 Clone: HE12

 Isotype: IgG1

 Immunogen: Synthetic peptide corresponding to human cyclin E protein

 Antigen Species: Human

 Positive Control: Breast carcinoma

 Target: Cyclin E

 Localization: Nuclear

 Storage Buffer: Phosphate-buffered saline containing sodium azide

 Application Note: For IHC-P: Use at a dilution of 1:25-1:50 in an ABC method for 30 min at RT. High temperature antigen unmasking with 10mM citrate buffer, pH 6.0 is required prior to immunostaining. For WB: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

 Cellular Localization: Nuclear

 Source/Host: Mouse

 Purity/Purification: Purified IgG

 Clonality: Monoclonal

 Crossreactivity: Human - Not yet tested in other species

 Format: Liquid

 Storage: Keep as concentrated solution, aliquot and store at 4C. Do not freeze.

 Shipping: Products may be shipped on ice pack or dry ice.
 APPLICATIONS for CYCLIN E ANTIBODY:
 IHC-P, WB: Tested
 TESTING: (secondary reagents and protocols )
 Not Available
 CYCLIN E ANTIBODY TARGET DESCRIPTION:
Synonym Names for Cyclin E antibody: Cyclin E; 898; CCNE1; 123837; P24864; CCNE;; Mouse monoclonal [HE12] to Cyclin E; 898; CCNE1; 123837; P24864; CCNE;; G1/S-specific cyclin-E1

Cyclin proteins are a family of related proteins that control the progression of the eukaryotic cell cycle. Overexpression of cyclin E shortens the length of the G1 phase, accelerating progression of S phase. The activity of cyclin E is mediated through its activation of cyclin dependent kinase 2 (cdk2) protein and is modulated by the presence of tumor suppressor proteins such as p16.

Function: Essential for the control of the cell cycle at the G1/S (start) transition.

Subunit: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1.

Subcellular Location: Nucleus.

Tissue Specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.

Ptm: Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity: Belongs to the cyclin family. Cyclin E subfamily.

Cyclin E [HE12] reacts with human - not yet tested in other species.

OMIM: 123837; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Cell cycle 04110
KEGG pathway: Prostate cancer 05215
KEGG pathway: Small cell lung cancer 05222
Reactome Event:Cell Cycle Checkpoints 69620
Reactome Event:Cell Cycle, Mitotic 69278

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 PRODUCT INTERACTIONS:
 Cyclin E [HE12] interacts with BRCA1, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 [9F12], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 [MS110], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 [MS13], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 [17F8], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 [17F8], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 [8F7], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 [8F7], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 [6B4], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 [6B4], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 (Phospho-Ser1524), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 (Phospho-Ser1423), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 (Ab-1423), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 (Phospho-Ser1524) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 (Phospho-Ser1423) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 [9F12], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1 [GLK-2], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with BRCA1, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with CDK2, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with Cdk2, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with CDK2 (Phospho-Thr160), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with CDK2 (Ab-160), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with CDK2 (Phospho-Thr160) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with CDK2, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with Anti-cdk2, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with Cdk2 (C-term), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with Cdk2 Phospho (pT14), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with Cdk2 Phospho (pY15), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with cN RAS [F155-227], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with WAF1 [B459], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p21 [AC8.3], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p21 [WA-1], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p21 (WAF-1), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p21, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p21/WAF1, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p21 Phospho (pS145), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p27/kip1, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p27 KIP1 [DCS-72.F6], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p27Kip1 (Phospho-Thr187), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p27Kip1 (Ab-10) Antibody, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p27Kip1 (Phospho-Thr187) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p27kip1, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p27 (Kip1) (pS10) Phospho, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with MRE11, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with Mre11 [12D7], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with Mre11 [12D7], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with NBS1, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p95/NBS1 (Phospho-Ser343), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p95/NBS1 (Ab-343), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p95/NBS1 (Phospho-Ser343) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with NBS1 [1D7], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with NBS1 [1D7], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with NBS1 [1C3], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with NBS1 [1C3], IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with Nibrin, IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with Nibrin/NBS1 Phospho (pS343), IgG (GenWay Catalog #: 20-272-192543).
 Cyclin E [HE12] interacts with p95 NBS1 Phospho (pS432), IgG (GenWay Catalog #: 20-272-192543).
SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: Cyclin E antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Cyclin E antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Cyclin E antibody, all related information, articles, resources about Cyclin E antibody are being stored on our online database. Let us know if you have questions regarding this product.

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