Interferon gamma antibody, Interferon gamma [H3-1] Antibody, Mouse Monoclonal Antibody

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Interferon gamma [H3-1] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-192867

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Related Product Names:

- Interferon gamma antibody; Interferon gamma; IFG, IFI, IFN Gamma, IFN Immune, IFNG, Immune interferon, Interferon gamma precursor,; Interferon gamma [H3-1]
- Mouse monoclonal [H3 - 1] to Interferon gamma; IFG IFI IFN Gamma IFN Immune IFNG Immune interferon Interferon gamma precursor; IFG IFI IFN Gamma IFN Immune IFNG Immune interferon Interferon gamma precursor

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Interferon gamma	Gene Name Synonym: IFG, IFI, IFN Gamma, IFN Immune, IFNG, Immune interferon, Interferon gamma precursor,
Gi #: N/A	NCBI Acc #: NP_000610.2	Swiss Prot Acc #: P01579
Length (aa): N/A	Mol. Weight (Da): 19348	Chrom Location: N/A

Clone: H3-1

Isotype: IgG1

Immunogen: Recombinant full length protein.

Specificity: Reacts with human interferon gamma.

Target: Interferon gamma

Localization: Secreted

Storage Buffer: PBS with 0.1% sodium azide, pH 7.4

Application Note: This antibody can be used to neutralize the anti-viral activity of interferon gamma. Can also be used for the isolation and purification of recombinant interferon gamma.

Cellular Localization: Secreted

Myeloma: Sp2/0-Ag14

Source/Host: Mouse

Purity/Purification: Protein A purified

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Storage: Keep as concentrated solution, aliquot and store at 4C. Do not freeze. We recommend to parafilm vials during storage to prevent evaporation of buffer.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for INTERFERON GAMMA ANTIBODY:

ELISA, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

INTERFERON GAMMA ANTIBODY TARGET DESCRIPTION:

Synonym Names for Interferon gamma antibody: Interferon gamma; IFG, IFI, IFN Gamma, IFN Immune, IFNG, Immune interferon, Interferon gamma precursor,; Mouse monoclonal [H3 - 1] to Interferon gamma; IFG IFI IFN Gamma IFN Immune IFNG Immune interferon Interferon gamma precursor; IFG IFI IFN Gamma IFN Immune IFNG Immune interferon Interferon gamma precursor

This antibody is used to detect human interferon gamma.

Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Subunit: Homodimer.

Subcellular Location: Secreted.

Tissue Specificity: Released primarily from activated T lymphocytes.

Ptm: Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.

Disease: In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.

Pharmaceutical: Available under the name Actimmune (Genentech). Used for reducing the frequency and severity of serious infections associated with chronic granulomatous disease (CGD).

Similarity: Belongs to the type II (or gamma) interferon family.

Interferon gamma [H3-1] reacts with human - not yet tested in other species.

OMIM: 147570; gene. [NCBI / EBI]
609135; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Cytokine-cytokine receptor interaction 04060
KEGG pathway: Jak-STAT signaling pathway 04630
KEGG pathway: Natural killer cell mediated cytotoxicity 04650
KEGG pathway: Regulation of autophagy 04140
KEGG pathway: T cell receptor signaling pathway 04660
KEGG pathway: TGF-beta signaling pathway 04350
KEGG pathway: Type I diabetes mellitus 04940

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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: Interferon gamma antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Interferon gamma antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Interferon gamma antibody, all related information, articles, resources about Interferon gamma antibody are being stored on our online database. Let us know if you have questions regarding this product.

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