Hemoglobin antibody, Hemoglobin [901] Antibody, Mouse Monoclonal Antibody

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Hemoglobin [901] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-193038

Buy Hemoglobin antibody -

Size:

Related Product Names:

- Hemoglobin antibody; Hemoglobin; 3039; HBA1; 141800; Q3MIF5; CD31; MGC126895; MGC126897; 3043; HBB; 141900; P68871; CD113t-C; HBD; hemoglobin; 3047; HBG1; 142200; Hemoglobin [901]
- Mouse monoclonal [901] to Hemoglobin; Hemoglobin subunit alpha

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Hemoglobin	Gene Name Synonym: 3039; HBA1; 141800; Q3MIF5; CD31; MGC126895; MGC126897; 3043; HBB; 141900; P68871; CD113t-C; HBD; hemoglobin; 3047; HBG1; 142200
Gi #: N/A	NCBI Acc #: N/A	Swiss Prot Acc #: Q3MIF5
Length (aa): N/A	Mol. Weight (Da): 15258	Chrom Location: N/A

Clone: 901

Isotype: IgG1

Light chain: kappa

Immunogen: Full length native protein (purified) (Human)

Antigen Species: Human

Target: Hemoglobin

Localization: Secreted

Concentration: 1.1 mg/ml

Purification Note: From mouse ascitic fluid

Storage Buffer: Phosphate-buffered saline, pH 7.4, containing no preservatives

Application Note: For ELISA: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Source/Host: Mouse

Purity/Purification: Protein G purified

Clonality: Monoclonal

Crossreactivity: Human - Does not cross-react with Bovine, Chicken, Horse, Pig, and Sheep - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for HEMOGLOBIN ANTIBODY:

ELISA: Tested

TESTING: (secondary reagents and protocols )

Not Available

HEMOGLOBIN ANTIBODY TARGET DESCRIPTION:

Synonym Names for Hemoglobin antibody: Hemoglobin; 3039; HBA1; 141800; Q3MIF5; CD31; MGC126895; MGC126897; 3043; HBB; 141900; P68871; CD113t-C; HBD; hemoglobin; 3047; HBG1; 142200; Mouse monoclonal [901] to Hemoglobin; Hemoglobin subunit alpha

Hemoglobin is involved in oxygen transport from the lung to the various peripheral tissues.The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult Hemoglobin. The normal adult Hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta zero thalassemia. Reduced amounts of detectable beta globin causes beta plus thalassemia.

Function: Involved in oxygen transport from the lung to the various peripheral tissues.

Subunit: Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA); two alpha chains and two delta chains in adult hemoglobin A2 (HbA2); two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two alpha chains and two gamma chains in fetal hemoglobin F (HbF).

Tissue Specificity: Red blood cells.

Ptm: The initiator Met is not cleaved in variant Thionville and is acetylated.

Disease: Defects in HBA1/HBA2 may be a cause of Heinz body anemias [MIM:140700]. This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency.

Disease: Defects in HBA1/HBA2 are the cause of alpha-thalassemia [MIM:141800, 604131]. The thalassemias are the most common monogenic diseases and occur mostly in Mediterranean and Southeast Asian populations. The hallmark of alpha-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. The level of alpha chain production can range from none to very nearly normal levels. Deletion of both copies of each of the two alpha-globin genes causes alpha(0)-thalassemia, also known as homozygous alpha thalassemia. Due to the complete absence of alpha chains, the predominant fetal hemoglobin is a tetramer of gamma-chains (Bart hemoglobin) that has essentially no oxygen carrying capacity. This causes oxygen starvation in the fetal tissues leading to prenatal lethality or early neonatal death. The loss of three alpha genes results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia known as hemoglobin H disease. Untreated, most patients die in childhood or early adolescence. The loss of two alpha genes results in mild alpha-thalassemia, also known as heterozygous alpha-thalassemia. Affected individuals have small red cells and a mild anemia (microcytosis). If three of the four alpha-globin genes are functional, individuals are completely asymptomatic. Some rare forms of alpha-thalassemia are due to point mutations (non-deletional alpha-thalassemia). The thalassemic phenotype is due to unstable globin alpha chains that are rapidly catabolized prior to formation of the alpha-beta heterotetramers.

Disease: Alpha(0)-thalassemia is associated with nonimmune hydrops fetalis [MIM:236750]. Hydrops fetalis is a generalized edema of the fetus with fluid accumulation in the body cavities.

Miscellaneous: Gives blood its red color.

Similarity: Belongs to the globin family.

Hemoglobin [901] reacts with human - does not cross-react with bovine, chicken, horse, pig, and sheep - not yet tested in other species .

OMIM: 140700; phenotype. [NCBI / EBI]
141800; gene+phenotype. [NCBI / EBI]
141850; gene. [NCBI / EBI]
141860; gene. [NCBI / EBI]
236750; phenotype. [NCBI / EBI]
604131; phenotype. [NCBI / EBI]

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PRODUCT INTERACTIONS:

Hemoglobin [901] interacts with Hemorphin-7, Peptide (GenWay Catalog #: 20-272-193038).

Hemoglobin [901] interacts with HEMOGLOBIN, IgG (GenWay Catalog #: 20-272-193038).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: Hemoglobin antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Hemoglobin antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Hemoglobin antibody, all related information, articles, resources about Hemoglobin antibody are being stored on our online database. Let us know if you have questions regarding this product.

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