L1CAM antibody, L1CAM [UJ127.11] Antibody, Mouse Monoclonal Antibody

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L1CAM [UJ127.11] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-193052

Buy L1CAM antibody -

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Related Product Names:

- L1CAM antibody; L1CAM; antigen identified by monoclonal antibody R1; CD171; HGNC:7086; HSAS1; L1 cell adhesion molecule; MASA; MIC5; N CAML1; NEURAL CE; L1CAM [UJ127.11]
- Mouse monoclonal [UJ127.11] to L1CAM; Neural cell adhesion molecule L1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: L1CAM	Gene Name Synonym: antigen identified by monoclonal antibody R1; CD171; HGNC:7086; HSAS1; L1 cell adhesion molecule; MASA; MIC5; N CAML1; NEURAL CE
Gi #: N/A	NCBI Acc #: NP_000416.1	Swiss Prot Acc #: P32004
Length (aa): N/A	Mol. Weight (Da): 140003	Chrom Location: N/A

Clone: UJ127.11

Isotype: IgG1

Immunogen: Tissue preparation: Homogenous suspension of human fetal brain

Antigen Species: Human

Specificity: UJ127.11 may be useful in the diagnosis of embryonic tumours (e.g. neuroblastoma).

Target: L1CAM

Localization: Cell Membrane

Concentration: ~2 mg/ml

Storage Buffer: Preservative: 15 mM Sodium Azide. Constituents: 0.01 M PBS, pH 7.4

Application Note: IP: Use at an assay dependent dilution. WB: a working concentration of 0.25-0.5 mg/mL is recommended using cell extracts of G361 cells (human melanoma).Predicted molecular weight: 140 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Cell Membrane

Myeloma: P3x63-Ag8.653

Source/Host: Mouse

Purity/Purification: IgG fraction

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for L1CAM ANTIBODY:

FACS, IHC, IP, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

L1CAM ANTIBODY TARGET DESCRIPTION:

Synonym Names for L1CAM antibody: L1CAM; antigen identified by monoclonal antibody R1; CD171; HGNC:7086; HSAS1; L1 cell adhesion molecule; MASA; MIC5; N CAML1; NEURAL CE; Mouse monoclonal [UJ127.11] to L1CAM; Neural cell adhesion molecule L1

The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm.

Function: Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.

Subcellular Location: Cell membrane; Single-pass type I membrane protein.

Disease: Defects in L1CAM are the cause of hydrocephalus due to stenosis of the aqueduct of Sylvius (HSAS) [MIM:307000]. Hydrocephalus is a condition in which abnormal accumulation of cerebrospinal fluid in the brain causes increased intracranial pressure inside the skull. This is usually due to blockage of cerebrospinal fluid outflow in the brain ventricles or in the subarachnoid space at the base of the brain. In children is typically characterized by enlargement of the head, prominence of the forehead, brain atrophy, mental deterioration, and convulsions. In adults the syndrome includes incontinence, imbalance, and dementia. HSAS is characterized by mental retardation and enlarged brain ventricles.

Disease: Defects in L1CAM are the cause of mental retardation-aphasia-shuffling gait-adducted thumbs syndrome (MASA) [MIM:303350]; also known as corpus callosum hypoplasia, psychomotor retardation, adducted thumbs, spastic paraparesis, and hydrocephalus or CRASH syndrome. MASA is an X-linked recessive syndrome with a highly variable clinical spectrum. Main clinical features include spasticity and hyperreflexia of lower limbs, shuffling gait, mental retardation, aphasia and adducted thumbs. The features of spasticity have been referred to as complicated spastic paraplegia type 1 (SPG1). Some patients manifest corpus callosum hypoplasia and hydrocephalus. Inter- and intrafamilial variability is very wide, such that patients with hydrocephalus, MASA, SPG1, and agenesis of corpus callosum can be present within the same family.

Disease: Defects in L1CAM are the cause of spastic paraplegia X-linked type 1 (SPG1) [MIM:303350]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.

Disease: Defects in L1CAM may contribute to Hirschsprung disease (HSCR) [MIM:142623]. It may do so by modifying the effects of a Hirschsprung disease-associated gene to cause intestinal aganglionosis.

Disease: Defects in L1CAM are a cause of partial agenesis of the corpus callosum [MIM:304100]; a X-linked disorder.

Similarity: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

Similarity: Contains 5 fibronectin type-III domains.

Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

L1CAM [UJ127.11] reacts with human - not yet tested in other species.

OMIM: 142623; phenotype. [NCBI / EBI]
303350; phenotype. [NCBI / EBI]
304100; phenotype. [NCBI / EBI]
307000; phenotype. [NCBI / EBI]
308840; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Axon guidance 04360
KEGG pathway: Cell adhesion molecules (CAMs) 04514

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Precautions: L1CAM antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of L1CAM antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about L1CAM antibody, all related information, articles, resources about L1CAM antibody are being stored on our online database. Let us know if you have questions regarding this product.

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