IDE antibody, IDE [9B12.225] Antibody, Mouse Monoclonal Antibody

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IDE [9B12.225] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-193204

Buy IDE antibody -

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Related Product Names:

- IDE antibody; IDE; 3416; IDE; 146680; P14735; INSULYSIN;; IDE [9B12.225]
- Mouse monoclonal [9B12.225] to Insulin degrading enzyme / IDE; 3416; IDE; 146680; P14735; INSULYSIN;; Insulin-degrading enzyme

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: IDE	Gene Name Synonym: 3416; IDE; 146680; P14735; INSULYSIN;
Gi #: N/A	NCBI Acc #: NP_004960.2	Swiss Prot Acc #: P14735
Length (aa): N/A	Mol. Weight (Da): 117968	Chrom Location: N/A

Clone: 9B12.225

Isotype: IgG1

Light chain: kappa

Immunogen: purified human erythrocyte IDE.

Antigen Species: Human

Target: IDE

Localization: Cytoplasmic

Concentration: ~1 mg/ml

Storage Buffer: Preservative: None; Constituents: Ascites

Application Note: IHC-P: Use at an assay dependent dilution. IP: 1/150. WB: 1/1000. Detects a band of approximately ~110 kDa (predicted molecular weight: 110 kDa). Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular Localization: Cytoplasmic

Source/Host: Mouse

Purity/Purification: Ascites

Clonality: Monoclonal

Crossreactivity: Reacts with Human, Rat, Hamster and Monkey. Does not react with Mouse.Not yet tested in other species.

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for IDE ANTIBODY:

IHC-P, IP, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

IDE ANTIBODY TARGET DESCRIPTION:

Synonym Names for IDE antibody: IDE; 3416; IDE; 146680; P14735; INSULYSIN;; Mouse monoclonal [9B12.225] to Insulin degrading enzyme / IDE; 3416; IDE; 146680; P14735; INSULYSIN;; Insulin-degrading enzyme

Insulin-degrading enzyme (IDE) is a metalloprotease with a molecular weight of 110 kDa that is expressed in many tissue types, with high concentrations noted in brain. IDE has a preferential affinity for insulin such that the presence of insulin will inhibit IDE-mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A-beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A-beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma-secretase cleaved APP that may function in nuclear signaling.

Function: May play a role in the cellular processing of insulin. May be involved in intercellular peptide signaling.

Catalytic Activity: Degradation of insulin, glucagon and other polypeptides. No action on proteins.

Cofactor: Binds 1 zinc ion per subunit (By similarity).

Subunit: Homodimer (Probable).

Subcellular Location: Cytoplasm.

Ptm: The N-terminus is blocked.

Similarity: Belongs to the peptidase M16 family [view classification].

IDE [9B12.225] reacts with reacts with human, rat, hamster and monkey. does not react with mouse.not yet tested in other species..

OMIM: 146680; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Alzheimer's disease 05010

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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: IDE antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of IDE antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about IDE antibody, all related information, articles, resources about IDE antibody are being stored on our online database. Let us know if you have questions regarding this product.

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