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| BRCA2 [3E6] Antibody, Mouse Monoclonal Antibody |
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| Catalog Number: 20-272-193236 |
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| Related Product Names:
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BRCA2 antibody; BRCA2; breast cancer protein, brca; BRCA2 [3E6]
- Mouse monoclonal [3E6] to BRCA2; 675; BRCA2; 114480; P51587; BRCC2; FACD; FAD; FAD1; FANCB; FANCD; FANCD1;; 675; BRCA2; 114480; P51587; BRCC2; FACD; FAD; FAD1; FANCB; FANCD; FANCD1; |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: BRCA2 |
Gene Name Synonym: breast cancer protein, brca |
Gi #:
N/A |
NCBI Acc #:
NP_000050.2 |
Swiss Prot Acc #:
P51587 |
Length (aa): N/A |
Mol. Weight (Da): 384225 |
Chrom Location: N/A |
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 Clone: 3E6
Isotype: IgG1
Light chain: kappa
Immunogen: Amino acids 188-563 of human BRCA2 expressed in E. coli. BRCA2-BBA.
Antigen Species: Human
Specificity: This antibody recognizes the BRCA2 gene product, a 390-kDa nuclear protein.
Target: BRCA2
Localization: Nuclear
Concentration: 1 mg/ml
Purification Note: From mouse ascitic fluid.
Storage Buffer: Phosphate-buffered saline, pH 7.2, no preservative added.
Application Note: Do not boil samples for longer than two minutes. For IP: Use at a concentration of 2-5 µg/ml. For WB: Use at a concentration of 1-5 µg/ml. Predicted molecular weight: 390 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Source/Host: Mouse
Purity/Purification: Protein G affinity purified.
Clonality: Monoclonal
Crossreactivity: Human - Not yet tested in other species
Format: Liquid
Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for BRCA2 ANTIBODY: |
| IP, WB: Tested |
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| BRCA2 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for BRCA2 antibody: BRCA2; breast cancer protein, brca; Mouse monoclonal [3E6] to BRCA2; 675; BRCA2; 114480; P51587; BRCC2; FACD; FAD; FAD1; FANCB; FANCD; FANCD1;; 675; BRCA2; 114480; P51587; BRCC2; FACD; FAD; FAD1; FANCB; FANCD; FANCD1;
BRCA2-3E6 recognizes the BRCA2 gene product, a 390kDa nuclear protein. The BRCA2 gene was originally isolated based on its importance in the predisposition of women to early-onset breast and ovarian cancers, suggesting mutations affect its tumor suppressor-like activity. Targeted disruption of the BRCA2 gene in mice and binding of Rad51 to its carboxyl terminus have indicated an involvement in DNA recombination and double strand break repair.
Function: Involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation.
Subunit: Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoints functions. Interacts with WDR16.
Tissue Specificity: Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.
Ptm: Phosphorylated by ATM upon irradiation-induced DNA damage.
Polymorphism: Genetic variations in BRCA2 may underlie susceptibility to uveal melanoma [MIM:155720]. Uveal melanoma is the most common type of ocular malignant tumor, consisting of overgrowth of uveal melanocytes and often preceded by a uveal nevus.
Disease: Defects in BRCA2 are a cause of genetic susceptibility to breast cancer (BC) [MIM:600185, 114480]. BC is an extremely common malignancy, affecting one in eight women during their lifetime. A positive family history has been identified as major contributor to risk of development of the disease, and this link is striking for early-onset breast cancer. Mutations in BRCA2 are thought to be responsible for some inherited breast cancer. It is linked with male breast cancer.
Disease: Defects in BRCA2 are the cause of Fanconi anemia complementation group D type 1 (FANCD1) [MIM:605724]. Fanconi anemia [MIM:227650] is an autosomal recessive disorder affecting all bone marrow elements and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes.
Similarity: Contains 8 BRCA2 repeats.
BRCA2 [3E6] reacts with human - not yet tested in other species .
OMIM: 114480; phenotype. [NCBI / EBI]
155720; phenotype. [NCBI / EBI]
227650; phenotype. [NCBI / EBI]
600185; gene+phenotype. [NCBI / EBI]
605724; phenotype. [NCBI / EBI]
Pathways:
KEGG pathway: Pancreatic cancer 05212
Reactome Event:DNA Repair 73894
Products similar to BRCA2 antibody:
IgG
 BRCA2 [5F6], IgG
BRCA2 [9D3], IgG
BRCA1 [9F12], IgG
BRCA1 [8F7], IgG
BRCA1 [17F8], IgG
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| PRODUCT INTERACTIONS: |
BRCA2 [3E6] interacts with c-Abl phospho Y245, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with c-Abl (Phospho-Tyr412), IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with c-Abl (Ab-412), IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with c-Abl (Phospho-Tyr412) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Herpes Type 6 p150, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with c-Abl (ready-to-use), IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with c-Abl, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with c-Abl [19-110], IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with c-Abl [ABL-148], IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with c-Abl phospho Y412, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with c-Abl, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with c-Abl, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with FANCD2 [103], IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with FANCD2 [6], IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with FYN, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with FYN [FYN-01], IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Fyn-p59 Human, Protein (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with FYN, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Fyn (p59Fyn), IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Growth factor receptor-bound protein 2, Protein (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Grb2, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with GRB2 [R11], IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with GRB2 [R13], IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Grb2, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Grb2, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Grb2, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Grb2, C-Term, IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with GRB2 (N-term), IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Recombinant Human Growth Factor Receptor-Bound Protein 2, Protein (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Rad51 [14B4], IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Rad51 [13E4], IgG (GenWay Catalog #: 20-272-193236).
BRCA2 [3E6] interacts with Rad51 [14B4], IgG (GenWay Catalog #: 20-272-193236).
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: BRCA2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of BRCA2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about BRCA2 antibody, all related information, articles, resources about BRCA2 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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