FEN1 antibody, FEN1 [4E7] Antibody, Mouse Monoclonal Antibody

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FEN1 [4E7] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-193280

Buy FEN1 antibody -

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Related Product Names:

- FEN1 antibody; FEN1; Flap endonuclease, FEN-1, Flap exonuclease, FEN1, Five prime Exonuclease; FEN1 [4E7]
- Mouse monoclonal antibody to human FEN1; 2237; FEN1; 600393; P39748; FEN-1; MF1; RAD2;; 2237; FEN1; 600393; P39748; FEN-1; MF1; RAD2;

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: FEN1	Gene Name Synonym: Flap endonuclease, FEN-1, Flap exonuclease, FEN1, Five prime Exonuclease
Gi #: N/A	NCBI Acc #: NP_004102.1	Swiss Prot Acc #: P39748
Length (aa): N/A	Mol. Weight (Da): 42593	Chrom Location: N/A

Clone: 4E7

Isotype: IgG1

Light chain: kappa

Immunogen: Recombinant human FEN-1 protein encoding amino acids 1-380 purified E. coli.

Antigen Species: Human

Positive Control: MCF7

Target: FEN1

Localization: Nuclear

Concentration: 1 mg/ml

Purification Note: From hybridoma tissue culture supernatant

Storage Buffer: Phosphate-buffered saline, pH 7.4, containing no preservatives

Application Note: For WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 43 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Source/Host: Mouse

Purity/Purification: Protein G Affinity Purified

Clonality: Monoclonal

Crossreactivity: Human - Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for FEN1 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

FEN1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for FEN1 antibody: FEN1; Flap endonuclease, FEN-1, Flap exonuclease, FEN1, Five prime Exonuclease; Mouse monoclonal antibody to human FEN1; 2237; FEN1; 600393; P39748; FEN-1; MF1; RAD2;; 2237; FEN1; 600393; P39748; FEN-1; MF1; RAD2;

FEN-1 (Flap Endonuclease and Five prime Exonuclease) is a 42 a protein that functions as an endonuclease that cleaves branched DNA structures containing single-stranded 5' flaps or as an exonuclease on DNA nicks and gaps. FEN-1 endonuclease and exonuclease activities are stimulated by an association with proliferating cell nuclear antigen (PCNA) in the nucleus. FEN-1 is believed to have important roles in DNA replication and repair and is required in cell-free DNA replication systems.

Function: Endonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Also possesses 5' to 3' exonuclease activity on niked or gapped double-stranded DNA, and exhibits RNase H activity.

Subunit: Interacts with PCNA. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300.

Subcellular Location: Nucleus.

Ptm: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.

Similarity: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

FEN1 [4E7] reacts with human - not yet tested in other species .

OMIM: 600393; gene. [NCBI / EBI]

Products similar to FEN1 antibody:

IgG

FEN1, IgG

FEN1 [4E7], IgG

FEN1, IgG

PRODUCT INTERACTIONS:

FEN1 [4E7] interacts with BLM, IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with Blooms Syndrome protein blm, IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with Blooms Syndrome protein blm [BFL-103], IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with Blooms Syndrome protein blm, IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with PCNA Human, Protein (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with PCNA [PC10], IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with PCNA [PC10] (ready-to-use), IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with PCNA [PC8], IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with PCNA (proliferating cell nuclear antigen), IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with PCNA, IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with Rabbit anti Alga PCNA, IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with PCC, Native_Protein (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with p37, IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with PCNA, IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with p37 [1320], IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with PCNA [339], IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with PCNA (ready-to-use), IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with PCNA, IgG (GenWay Catalog #: 20-272-193280).

FEN1 [4E7] interacts with WRN, IgG (GenWay Catalog #: 20-272-193280).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: FEN1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of FEN1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about FEN1 antibody, all related information, articles, resources about FEN1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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