FKHR antibody, FKHR [14E4] Antibody, Mouse Monoclonal Antibody

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FKHR [14E4] Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-272-193282

Buy FKHR antibody -

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Related Product Names:

- FKHR antibody; FKHR; ForKHead in Rhabdomyosarcoma, Fork head, FKH R; FKHR [14E4]
- Mouse monoclonal antibody to human FKHR; 2308; FOXO1A; 136533; Q12778; FKH1; FKHR; FOXO1;; 2308; FOXO1A; 136533; Q12778; FKH1; FKHR; FOXO1;

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: FKHR	Gene Name Synonym: ForKHead in Rhabdomyosarcoma, Fork head, FKH R
Gi #: N/A	NCBI Acc #: NP_002006.2	Swiss Prot Acc #: Q12778
Length (aa): N/A	Mol. Weight (Da): 69662	Chrom Location: N/A

Clone: 14E4

Isotype: IgG2b

Light chain: kappa

Immunogen: Amino acids 242-655 of FKHR expressed in E. coli.

Positive Control: Cos 1 cells transfected with human FKHR

Target: FKHR

Concentration: 1 mg/ml

Purification Note: From hybridoma tissue culture supernatant

Storage Buffer: Phosphate-buffered saline, pH 7.4, containing no preservatives

Application Note: For WB: Use at a concentration of 0.1 - 2.0 µg/ml. Predicted molecular weight: 70 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Source/Host: Mouse

Purity/Purification: Protein G Affinity Purified

Clonality: Monoclonal

Crossreactivity: Human- Not yet tested in other species

Format: Liquid

Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for FKHR ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

FKHR ANTIBODY TARGET DESCRIPTION:

Synonym Names for FKHR antibody: FKHR; ForKHead in Rhabdomyosarcoma, Fork head, FKH R; Mouse monoclonal antibody to human FKHR; 2308; FOXO1A; 136533; Q12778; FKH1; FKHR; FOXO1;; 2308; FOXO1A; 136533; Q12778; FKH1; FKHR; FOXO1;

FKHR-14E4 recognizes FKHR (ForKHead in Rhabdomyosarcoma), a 70a protein, which is one member in a subfamily of the forkhead homeotic gene family of transcription factors. Recent experiments have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the carboxyl terminal region of the FKHR protein.

Function: Transcription factor.

Subunit: Interacts with LRPPRC (By similarity).

Subcellular Location: Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.

Tissue Specificity: Ubiquitous.

Ptm: Phosphorylated by AKT1; insulin-induced (By similarity). IGF1 rapidly induces phosphorylation of Ser-256, Thr-24, and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24, and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CK1, leading to nuclear exclusion and loss of function. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR.

Disease: Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.

Similarity: Contains 1 fork-head DNA-binding domain.

FKHR [14E4] reacts with human- not yet tested in other species .

OMIM: 136533; gene. [NCBI / EBI]
268220; phenotype. [NCBI / EBI]

Products similar to FKHR antibody:

IgG

FOXO1, IgG

FKHRL1 (Ab-253), IgG

FKHR (Ab-256), IgG

FOXO3A, IgG

FKHR [7H3], IgG

Peptide

FKHRL1 (Phospho-Ser253) Antibody Blocking Peptide, Peptide

FKHR (Phospho-Ser319) Antibody Blocking Peptide, Peptide

FKHR (Phospho-Ser256) Antibody Blocking Peptide, Peptide

PRODUCT INTERACTIONS:

FKHR [14E4] interacts with Anti-Dihydrotestosterone, IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Cell division control protein 2 homolog, IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 (cell division cycle 2. G1 to S and G2 to M), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Cdc2, IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 [A17], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 [Y100.4], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDK1 + CDK2 [AN21.2], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 [POH-1], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 [3E1.1], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 (Phospho-Thr161), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 (Phospho-Tyr15), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 (Ab-161), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 (Ab-15), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 (Phospho-Thr161) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 (Phospho-Tyr15) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Rabbit anti Cyclin cdc2 (p34), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Rabbit anti Cyclin cdk2, IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Anti-cdc2 (p34), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Cdc2, IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 phospho Y15 antibody, IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with CDC2 [B322 (POH-1)], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [B401 (AER303)], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [B402 (AER304)], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [B403 (AER308)], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [B404 (AER310)], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [B405 (AER311)], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [B406 (AER314)], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [B407 (AER315)], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [B408 (AER317)], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [B409 (AER320)], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [B30.1], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [6F11], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Phospho-Ser104), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Phospho-Ser106), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Phospho-Ser118), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Phospho-Ser167), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Ab-104), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Ab-106), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Ab-118), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Ab-167), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Phospho-Ser104) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Phospho-Ser106) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Phospho-Ser118) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor-alpha (Phospho-Ser167) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with Estrogen Receptor, IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ERa Human, Protein (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha, IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ESTROGEN RECEPTOR ALPHA, IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha (ready-to-use), IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [6F11], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha [1F3], IgG (GenWay Catalog #: 20-272-193282).

FKHR [14E4] interacts with ER alpha, IgG (GenWay Catalog #: 20-272-193282).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: FKHR antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of FKHR antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about FKHR antibody, all related information, articles, resources about FKHR antibody are being stored on our online database. Let us know if you have questions regarding this product.

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